Human Gene GTF2I (ENST00000573035.6_5) from GENCODE V47lift37
  Description: general transcription factor IIi, transcript variant 1 (from RefSeq NM_032999.4)
Gencode Transcript: ENST00000573035.6_5
Gencode Gene: ENSG00000263001.8_15
Transcript (Including UTRs)
   Position: hg19 chr7:74,072,044-74,175,022 Size: 102,979 Total Exon Count: 35 Strand: +
Coding Region
   Position: hg19 chr7:74,103,463-74,173,168 Size: 69,706 Coding Exon Count: 33 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesGeneReviews
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:74,072,044-74,175,022)mRNA (may differ from genome)Protein (998 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GTF2I
Diseases sorted by gene-association score: williams-beuren syndrome* (54), supravalvar aortic stenosis (19), chromosomal deletion syndrome (19), separation anxiety disorder (6), chromosomal disease (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -170.30356-0.478 Picture PostScript Text
3' UTR -303.901162-0.262 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Descriptions from all associated GenBank mRNAs
  AK292832 - Homo sapiens cDNA FLJ77440 complete cds, highly similar to Homo sapiens general transcription factor II, i (GTF2I), transcript variant 2, mRNA.
JD340131 - Sequence 321155 from Patent EP1572962.
AF015553 - Homo sapiens TFII-I protein (TFII-I) mRNA, complete cds.
JD178397 - Sequence 159421 from Patent EP1572962.
JD471510 - Sequence 452534 from Patent EP1572962.
JD178520 - Sequence 159544 from Patent EP1572962.
JD077969 - Sequence 58993 from Patent EP1572962.
JD220096 - Sequence 201120 from Patent EP1572962.
BC070484 - Homo sapiens general transcription factor II, i, mRNA (cDNA clone MGC:71186 IMAGE:5815493), complete cds.
JD072112 - Sequence 53136 from Patent EP1572962.
BC099907 - Homo sapiens general transcription factor II, i, mRNA (cDNA clone MGC:104586 IMAGE:5263270), complete cds.
AK294935 - Homo sapiens cDNA FLJ55916 complete cds, highly similar to General transcription factor II-I.
AF035737 - Homo sapiens general transcription factor 2-I (GTF2I) mRNA, complete cds.
AF038967 - Homo sapiens general transcription factor 2-I (GTF2I) mRNA, alternatively spliced product, complete cds.
AF038968 - Homo sapiens general transcription factor 2-I (GTF2I) mRNA, alternatively spliced product, complete cds.
AF038969 - Homo sapiens general transcription factor 2-I (GTF2I) mRNA, alternatively spliced product, complete cds.
JD271320 - Sequence 252344 from Patent EP1572962.
JD142502 - Sequence 123526 from Patent EP1572962.
JD405359 - Sequence 386383 from Patent EP1572962.
JD325323 - Sequence 306347 from Patent EP1572962.
BC004472 - Homo sapiens general transcription factor II, i, mRNA (cDNA clone IMAGE:3928557), complete cds.
U77948 - Human Bruton's tyrosine kinase-associated protein-135 mRNA, complete cds.
KJ904473 - Synthetic construct Homo sapiens clone ccsbBroadEn_13867 GTF2I gene, encodes complete protein.
AB385190 - Synthetic construct DNA, clone: pF1KB9055, Homo sapiens GTF2I gene for general transcription factor II-I, complete cds, without stop codon, in Flexi system.
BT007450 - Homo sapiens general transcription factor II, i mRNA, complete cds.
KY884638 - Homo sapiens GTF2I-BRAF fusion protein (GTF2I/BRAF fusion) mRNA, complete cds.
KJ534859 - Homo sapiens clone GTF2I_iso-D_adult-A01 general transcription factor IIi isoform D (GTF2I) mRNA, partial cds, alternatively spliced.
KJ534860 - Homo sapiens clone GTF2I_iso-A_adult-A06 general transcription factor IIi isoform A (GTF2I) mRNA, partial cds, alternatively spliced.
KJ534861 - Homo sapiens clone GTF2I_iso-B_fetal-F05 general transcription factor IIi isoform B (GTF2I) mRNA, partial cds, alternatively spliced.
KJ534862 - Homo sapiens clone GTF2I_iso-A_fetal-F09 general transcription factor IIi isoform A (GTF2I) mRNA, partial cds, alternatively spliced.
KJ534863 - Homo sapiens clone GTF2I_iso-C_fetal-F12 general transcription factor IIi isoform C (GTF2I) mRNA, partial cds, alternatively spliced.
KJ534965 - Homo sapiens clone GTF2I_iso-E_fetal-F02 general transcription factor IIi isoform E (GTF2I) mRNA, partial cds, alternatively spliced.
Y14946 - Homo sapiens mRNA for SPIN protein.
AK297238 - Homo sapiens cDNA FLJ56355 complete cds, highly similar to General transcription factor II-I.
DQ592163 - Homo sapiens piRNA piR-59275, complete sequence.
AK098799 - Homo sapiens cDNA FLJ25933 fis, clone JTH01746, highly similar to General transcription factor II, i, isoform 4.
AK095645 - Homo sapiens cDNA FLJ38326 fis, clone FCBBF3024935.
AK093663 - Homo sapiens cDNA FLJ36344 fis, clone THYMU2006813.
AK057670 - Homo sapiens cDNA FLJ33108 fis, clone TRACH2000974, weakly similar to Transcription factor TFII-I.
DQ786291 - Homo sapiens clone HLS_IMAGE_548957 mRNA sequence.
AK096095 - Homo sapiens cDNA FLJ38776 fis, clone KIDNE2018493.
AK057750 - Homo sapiens cDNA FLJ25021 fis, clone CBL01740.
JD467653 - Sequence 448677 from Patent EP1572962.
JD160040 - Sequence 141064 from Patent EP1572962.
JD520922 - Sequence 501946 from Patent EP1572962.
JD130109 - Sequence 111133 from Patent EP1572962.
JD410470 - Sequence 391494 from Patent EP1572962.
JD304443 - Sequence 285467 from Patent EP1572962.
JD557642 - Sequence 538666 from Patent EP1572962.
JD485670 - Sequence 466694 from Patent EP1572962.
DQ786322 - Homo sapiens clone HLS_IMAGE_840763 mRNA sequence.
JD052910 - Sequence 33934 from Patent EP1572962.
MH721921 - Homo sapiens GTF2I_1 (GTF2I) mRNA, complete sequence.
MH721912 - Homo sapiens GTF2IP1_1 (GTF2IP1) mRNA, complete sequence.
MH721913 - Homo sapiens GTF2IP1_2 (GTF2IP1) mRNA, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000573035.1, ENST00000573035.2, ENST00000573035.3, ENST00000573035.4, ENST00000573035.5, GTF2I , NM_032999, uc326cfm.1, uc326cfm.2, X5DR09, X5DR09_HUMAN
UCSC ID: ENST00000573035.6_5
RefSeq Accession: NM_032999.4

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene GTF2I:
williams (Williams Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.