ID:TF3A_HUMAN DESCRIPTION: RecName: Full=Transcription factor IIIA; Short=TFIIIA; FUNCTION: Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 9 C2H2-type zinc fingers. CAUTION: It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals. SEQUENCE CAUTION: Sequence=BAA06988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA06988.1; Type=Frameshift; Positions=319, 330;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92664
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC143711 - Homo sapiens cDNA clone IMAGE:9052225. D32257 - Homo sapiens GTF3A mRNA for Xenopus transcription factor IIIA homologue, complete cds. E10962 - cDNA's encoding hTFIIIA protein. AB590496 - Synthetic construct DNA, clone: pFN21AE1232, Homo sapiens GTF3A gene for general transcription factor IIIA, without stop codon, in Flexi system. JD025845 - Sequence 6869 from Patent EP1572962. JD027199 - Sequence 8223 from Patent EP1572962. U14134 - Human transcription factor IIIA (HTFIIIA) mRNA, partial cds. U20272 - Human DNA/RNA-binding protein mRNA, partial cds. JD029821 - Sequence 10845 from Patent EP1572962. AK057993 - Homo sapiens cDNA FLJ25264 fis, clone STM05057, highly similar to TRANSCRIPTION FACTOR IIIA. JD020295 - Sequence 1319 from Patent EP1572962. CU692321 - Synthetic construct Homo sapiens gateway clone IMAGE:100021331 3' read MTIF3 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q92664 (Reactome details) participates in the following event(s):
R-HSA-76052 Binding of TFIIIA To type 1 Promoter R-HSA-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
