ID:TF3C1_HUMAN DESCRIPTION: RecName: Full=General transcription factor 3C polypeptide 1; AltName: Full=TF3C-alpha; AltName: Full=TFIIIC box B-binding subunit; AltName: Full=Transcription factor IIIC 220 kDa subunit; Short=TFIIIC 220 kDa subunit; Short=TFIIIC220; AltName: Full=Transcription factor IIIC subunit alpha; FUNCTION: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TFIIIC subunit 1 family. SEQUENCE CAUTION: Sequence=AAA17985.1; Type=Frameshift; Positions=152, 189; Sequence=AAA85638.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential vector sequence at the N-terminus;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12789
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding GO:0003677 DNA binding GO:0005515 protein binding GO:0000995 transcription factor activity, core RNA polymerase III binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006359 regulation of transcription from RNA polymerase III promoter GO:0006383 transcription from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter GO:0009303 rRNA transcription GO:0009304 tRNA transcription GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter GO:0042797 tRNA transcription from RNA polymerase III promoter
BX648143 - Homo sapiens mRNA; cDNA DKFZp686O0870 (from clone DKFZp686O0870). BC151847 - Homo sapiens cDNA clone IMAGE:8860443, containing frame-shift errors. CR627430 - Homo sapiens mRNA; cDNA DKFZp686A111 (from clone DKFZp686A111). U02619 - Human TFIIIC Box B-binding subunit mRNA, complete cds. BC137229 - Homo sapiens general transcription factor IIIC, polypeptide 1, alpha 220kDa, mRNA (cDNA clone MGC:168849 IMAGE:9021226), complete cds. U06485 - Human transcription factor TFIIIC alpha subunit mRNA, partial cds. BC044857 - Homo sapiens general transcription factor IIIC, polypeptide 1, alpha 220kDa, mRNA (cDNA clone IMAGE:5113502), partial cds. AK131479 - Homo sapiens cDNA FLJ16647 fis, clone TESTI4032112. AK123999 - Homo sapiens cDNA FLJ42005 fis, clone SPLEN2030763, highly similar to Homo sapiens general transcription factor IIIC, polypeptide 1, alpha 220kDa (GTF3C1). BC052642 - Homo sapiens general transcription factor IIIC, polypeptide 1, alpha 220kDa, mRNA (cDNA clone IMAGE:6138423), partial cds. AK091032 - Homo sapiens cDNA FLJ33713 fis, clone BRAWH2008292, moderately similar to Human TFIIIC Box B-binding subunit mRNA. AX746742 - Sequence 267 from Patent EP1308459. JD514307 - Sequence 495331 from Patent EP1572962. JD393266 - Sequence 374290 from Patent EP1572962. JD054930 - Sequence 35954 from Patent EP1572962. JD085774 - Sequence 66798 from Patent EP1572962. JD390603 - Sequence 371627 from Patent EP1572962. JD043765 - Sequence 24789 from Patent EP1572962. JD376687 - Sequence 357711 from Patent EP1572962. JD482087 - Sequence 463111 from Patent EP1572962. JD382664 - Sequence 363688 from Patent EP1572962. JD193825 - Sequence 174849 from Patent EP1572962. JD116108 - Sequence 97132 from Patent EP1572962. JD189486 - Sequence 170510 from Patent EP1572962. JD415533 - Sequence 396557 from Patent EP1572962. JD226529 - Sequence 207553 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_RNApol3Pathway - RNA polymerase III transcription
Reactome (by CSHL, EBI, and GO)
Protein Q12789 (Reactome details) participates in the following event(s):
R-HSA-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex R-HSA-83788 Binding of TFIIIC to Type 2 promoter R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
