ID:TF3C4_HUMAN DESCRIPTION: RecName: Full=General transcription factor 3C polypeptide 4; EC=2.3.1.48; AltName: Full=TF3C-delta; AltName: Full=Transcription factor IIIC 90 kDa subunit; Short=TFIIIC 90 kDa subunit; Short=TFIIIC90; AltName: Full=Transcription factor IIIC subunit delta; FUNCTION: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the TFIIIC subunit 4 family. SEQUENCE CAUTION: Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKN8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0004402 histone acetyltransferase activity GO:0005515 protein binding GO:0008047 enzyme activator activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups
Biological Process: GO:0006351 transcription, DNA-templated GO:0006383 transcription from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter GO:0016573 histone acetylation GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter GO:0042797 tRNA transcription from RNA polymerase III promoter GO:0043085 positive regulation of catalytic activity
BC060821 - Homo sapiens general transcription factor IIIC, polypeptide 4, 90kDa, mRNA (cDNA clone IMAGE:4825930), with apparent retained intron. AF142328 - Homo sapiens transcription factor IIIC90 mRNA, complete cds. JD429961 - Sequence 410985 from Patent EP1572962. JD556807 - Sequence 537831 from Patent EP1572962. BC094774 - Homo sapiens general transcription factor IIIC, polypeptide 4, 90kDa, mRNA (cDNA clone MGC:104675 IMAGE:4830453), complete cds. BC011619 - Homo sapiens general transcription factor IIIC, polypeptide 4, 90kDa, mRNA (cDNA clone IMAGE:3960260), partial cds. BC022787 - Homo sapiens general transcription factor IIIC, polypeptide 4, 90kDa, mRNA (cDNA clone IMAGE:3845225), partial cds. JD426382 - Sequence 407406 from Patent EP1572962. BC104755 - Homo sapiens general transcription factor IIIC, polypeptide 4, 90kDa, mRNA (cDNA clone MGC:132415 IMAGE:8143758), complete cds. BC112245 - Homo sapiens general transcription factor IIIC, polypeptide 4, 90kDa, mRNA (cDNA clone MGC:138450 IMAGE:8327713), complete cds. DQ583454 - Homo sapiens piRNA piR-50566, complete sequence. JD440460 - Sequence 421484 from Patent EP1572962. AB529214 - Synthetic construct DNA, clone: pF1KB0410, Homo sapiens GTF3C4 gene for general transcription factor IIIC, polypeptide 4, 90kDa, without stop codon, in Flexi system. KJ897996 - Synthetic construct Homo sapiens clone ccsbBroadEn_07390 GTF3C4 gene, encodes complete protein. AK024655 - Homo sapiens cDNA: FLJ21002 fis, clone CAE03545, highly similar to AF142328 Homo sapiens transcription factor IIIC90 mRNA. AK027509 - Homo sapiens cDNA FLJ14603 fis, clone NT2RP1000357, highly similar to General transcription factor 3C polypeptide 4 (EC 2.3.1.48). AK126436 - Homo sapiens cDNA FLJ44472 fis, clone UTERU2029742. JD170547 - Sequence 151571 from Patent EP1572962. JD203102 - Sequence 184126 from Patent EP1572962. AJ420451 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 909091. JD308665 - Sequence 289689 from Patent EP1572962. DQ581889 - Homo sapiens piRNA piR-50001, complete sequence. AF086460 - Homo sapiens full length insert cDNA clone ZD85A02. JD158971 - Sequence 139995 from Patent EP1572962. JD208765 - Sequence 189789 from Patent EP1572962. JD181008 - Sequence 162032 from Patent EP1572962. JD135979 - Sequence 117003 from Patent EP1572962. JD135980 - Sequence 117004 from Patent EP1572962. JD135981 - Sequence 117005 from Patent EP1572962. BX537622 - Homo sapiens mRNA; cDNA DKFZp686J12188 (from clone DKFZp686J12188). AB072895 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla10797. AJ420430 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1674211.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_RNApol3Pathway - RNA polymerase III transcription
Reactome (by CSHL, EBI, and GO)
Protein Q9UKN8 (Reactome details) participates in the following event(s):
R-HSA-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex R-HSA-83788 Binding of TFIIIC to Type 2 promoter R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
