The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5Q8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0005515 protein binding GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006383 transcription from RNA polymerase III promoter GO:0035914 skeletal muscle cell differentiation GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter GO:0042797 tRNA transcription from RNA polymerase III promoter
AK225761 - Homo sapiens mRNA for General transcription factor 3C polypeptide 5 variant, clone: FCC134F02. AK311481 - Homo sapiens cDNA, FLJ18523. AK055092 - Homo sapiens cDNA FLJ30530 fis, clone BRAWH2001092, highly similar to General transcription factor 3C polypeptide 5. AF133124 - Homo sapiens transcription factor IIIC63 mRNA, complete cds. BC011355 - Homo sapiens general transcription factor IIIC, polypeptide 5, 63kDa, mRNA (cDNA clone MGC:18246 IMAGE:4157684), complete cds. BC017337 - Homo sapiens general transcription factor IIIC, polypeptide 5, 63kDa, mRNA (cDNA clone MGC:29524 IMAGE:4872395), complete cds. AK293980 - Homo sapiens cDNA FLJ54733 complete cds, highly similar to General transcription factor 3C polypeptide 5. AK097295 - Homo sapiens cDNA FLJ39976 fis, clone SPLEN2028994, highly similar to Homo sapiens transcription factor IIIC63 mRNA. AK000194 - Homo sapiens cDNA FLJ20187 fis, clone COLF0433. KJ897995 - Synthetic construct Homo sapiens clone ccsbBroadEn_07389 GTF3C5 gene, encodes complete protein. BC006409 - Homo sapiens general transcription factor IIIC, polypeptide 5, 63kDa, mRNA (cDNA clone IMAGE:3534349), containing frame-shift errors. AY007123 - Homo sapiens clone CDABP0017 mRNA sequence. DQ892071 - Synthetic construct clone IMAGE:100004701; FLH182892.01X; RZPDo839D09140D general transcription factor IIIC, polypeptide 5, 63kDa (GTF3C5) gene, encodes complete protein. DQ895265 - Synthetic construct Homo sapiens clone IMAGE:100009725; FLH182888.01L; RZPDo839D09139D general transcription factor IIIC, polypeptide 5, 63kDa (GTF3C5) gene, encodes complete protein. AJ420443 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1607066. BC030157 - Homo sapiens general transcription factor IIIC, polypeptide 5, 63kDa, mRNA (cDNA clone IMAGE:4561538), partial cds. BC009741 - Homo sapiens general transcription factor IIIC, polypeptide 5, 63kDa, mRNA (cDNA clone IMAGE:3927117), partial cds. AK024510 - Homo sapiens cDNA: FLJ20857 fis, clone ADKA01521, highly similar to AF133124 Homo sapiens transcription factor IIIC63 mRNA. JD559236 - Sequence 540260 from Patent EP1572962. JD120128 - Sequence 101152 from Patent EP1572962. JD231214 - Sequence 212238 from Patent EP1572962. JD078415 - Sequence 59439 from Patent EP1572962. JD225960 - Sequence 206984 from Patent EP1572962. JD346952 - Sequence 327976 from Patent EP1572962. JD490759 - Sequence 471783 from Patent EP1572962. JD458875 - Sequence 439899 from Patent EP1572962. JD375381 - Sequence 356405 from Patent EP1572962. JD317418 - Sequence 298442 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_RNApol3Pathway - RNA polymerase III transcription
Reactome (by CSHL, EBI, and GO)
Protein Q9Y5Q8 (Reactome details) participates in the following event(s):
R-HSA-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex R-HSA-83788 Binding of TFIIIC to Type 2 promoter R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
