Human Gene GTPBP2 (ENST00000307126.10_7) from GENCODE V47lift37
  Description: GTP binding protein 2, transcript variant 1 (from RefSeq NM_019096.5)
Gencode Transcript: ENST00000307126.10_7
Gencode Gene: ENSG00000172432.19_11
Transcript (Including UTRs)
   Position: hg19 chr6:43,588,231-43,597,001 Size: 8,771 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr6:43,589,351-43,596,899 Size: 7,549 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:43,588,231-43,597,001)mRNA (may differ from genome)Protein (602 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GTPB2_HUMAN
DESCRIPTION: RecName: Full=GTP-binding protein 2;
TISSUE SPECIFICITY: Predominantly expressed in thymus, spleen, and testis. Expressed at lower levels in brain, lung, kidney, and ovary.
INDUCTION: Up-regulated by IFNG/IFN-gamma in human monocytic cell line THP-1.
SIMILARITY: Belongs to the GTPBP1 GTP-binding protein family.
SEQUENCE CAUTION: Sequence=CAD38999.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.21 RPKM in Thyroid
Total median expression: 749.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.50102-0.466 Picture PostScript Text
3' UTR -387.501120-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000795 - ProtSyn_GTP-bd
IPR009001 - Transl_elong_EF1A/Init_IF2_C
IPR004160 - Transl_elong_EFTu/EF1A_C
IPR009000 - Transl_elong_init/rib_B-barrel

Pfam Domains:
PF00009 - Elongation factor Tu GTP binding domain

SCOP Domains:
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9BX10
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0002576 platelet degranulation
GO:0008150 biological_process

Cellular Component:
GO:0005576 extracellular region
GO:0031093 platelet alpha granule lumen
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AJ420518 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1962571.
AL834331 - Homo sapiens mRNA; cDNA DKFZp434J0250 (from clone DKFZp434J0250).
BC020980 - Homo sapiens GTP binding protein 2, mRNA (cDNA clone IMAGE:3848992), partial cds.
BC028347 - Homo sapiens GTP binding protein 2, mRNA (cDNA clone IMAGE:3929557), partial cds.
AK000430 - Homo sapiens cDNA FLJ20423 fis, clone KAT02589.
BC064968 - Homo sapiens GTP binding protein 2, mRNA (cDNA clone MGC:74725 IMAGE:6149902), complete cds.
AB024574 - Homo sapiens GTPBP2 mRNA for GTP-binding like protein 2, complete cds.
BC032315 - Homo sapiens GTP binding protein 2, mRNA (cDNA clone IMAGE:5219190), with apparent retained intron.
AF168990 - Homo sapiens putative GTP-binding protein (GTPBP2) mRNA, partial cds.
JD547488 - Sequence 528512 from Patent EP1572962.
JD154393 - Sequence 135417 from Patent EP1572962.
JD080837 - Sequence 61861 from Patent EP1572962.
JD555770 - Sequence 536794 from Patent EP1572962.
JD488557 - Sequence 469581 from Patent EP1572962.
JD385011 - Sequence 366035 from Patent EP1572962.
JD297640 - Sequence 278664 from Patent EP1572962.
JD456344 - Sequence 437368 from Patent EP1572962.
JD477225 - Sequence 458249 from Patent EP1572962.
JD533270 - Sequence 514294 from Patent EP1572962.
JD116049 - Sequence 97073 from Patent EP1572962.
JD292951 - Sequence 273975 from Patent EP1572962.
JD080348 - Sequence 61372 from Patent EP1572962.
JD302424 - Sequence 283448 from Patent EP1572962.
AK290267 - Homo sapiens cDNA FLJ76494 complete cds, highly similar to Homo sapiens GTPBP2 mRNA for GTP-binding like protein 2.
JD324604 - Sequence 305628 from Patent EP1572962.
JD275952 - Sequence 256976 from Patent EP1572962.
JD066184 - Sequence 47208 from Patent EP1572962.
JD237841 - Sequence 218865 from Patent EP1572962.
JD213767 - Sequence 194791 from Patent EP1572962.
KJ899008 - Synthetic construct Homo sapiens clone ccsbBroadEn_08402 GTPBP2-like gene, encodes complete protein.
AF116627 - Homo sapiens PRO1181 mRNA, complete cds.
CU687988 - Synthetic construct Homo sapiens gateway clone IMAGE:100021777 5' read GTPBP2 mRNA.
JD176813 - Sequence 157837 from Patent EP1572962.
JD037768 - Sequence 18792 from Patent EP1572962.
JD188567 - Sequence 169591 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BX10 (Reactome details) participates in the following event(s):

R-HSA-481007 Exocytosis of platelet alpha granule contents
R-HSA-114608 Platelet degranulation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000307126.1, ENST00000307126.2, ENST00000307126.3, ENST00000307126.4, ENST00000307126.5, ENST00000307126.6, ENST00000307126.7, ENST00000307126.8, ENST00000307126.9, GTPB2_HUMAN, GTPBP2 , NM_019096, Q5T7E8, Q8ND84, Q8TAH7, Q8WUA5, Q9BX10, Q9HCS9, Q9NRU4, Q9NX60, uc317nzm.1, uc317nzm.2
UCSC ID: ENST00000307126.10_7
RefSeq Accession: NM_019096.5
Protein: Q9BX10 (aka GTPB2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
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