Human Gene GTPBP6 (ENST00000326153.10_8) from GENCODE V47lift37

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Description: GTP binding protein 6 (putative) (from RefSeq NM_012227.4)
Gencode Transcript: ENST00000326153.10_8
Gencode Gene: ENSG00000178605.15_10
Transcript (Including UTRs)
Position: hg19 chrX:221,426-230,884 Size: 9,459 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chrX:221,741-230,884 Size: 9,144 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:221,426-230,884)			mRNA (may differ from genome)		Protein (284 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GTPB6_HUMAN DESCRIPTION: RecName: Full=Putative GTP-binding protein 6; AltName: Full=Pseudoautosomal GTP-binding protein-like; TISSUE SPECIFICITY: Ubiquitously expressed. MISCELLANEOUS: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. SIMILARITY: Belongs to the HflX GTPase family. SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain. SEQUENCE CAUTION: Sequence=AAH14636.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAP36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD97132.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA74749.2; Type=Miscellaneous discrepancy; Note=Has an upstream in-frame stop codon because of a region of poor sequence quality;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C063002 2,3-dimethoxy-1,4-naphthoquinone C009505 4,4'-diaminodiphenylmethane D000082 Acetaminophen D016604 Aflatoxin B1 D000965 Antimony D000966 Antimony Potassium Tartrate D002104 Cadmium D019256 Cadmium Chloride D004997 Ethinyl Estradiol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 37.87 RPKM in Ovary Total median expression: 1336.42 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-136.30	315	-0.433	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR006073 - GTP_binding_domain
IPR016496 - GTPase_HflX

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on O43824


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0005525 GTP binding GO:0043022 ribosome binding GO:0046872 metal ion binding Cellular Component: GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AK074528 - Homo sapiens cDNA FLJ90047 fis, clone HEMBA1002316, highly similar to GTP-binding protein 6. AK026462 - Homo sapiens cDNA: FLJ22809 fis, clone KAIA2927, highly similar to HSY14391 Homo sapiens mRNA for putative GTP-binding protein. AK024630 - Homo sapiens cDNA: FLJ20977 fis, clone ADSU01840, highly similar to HSY14391 Homo sapiens mRNA for putative GTP-binding protein. BC014636 - Homo sapiens GTP binding protein 6 (putative), mRNA (cDNA clone MGC:1170 IMAGE:3528598), complete cds. Y14391 - Homo sapiens mRNA for putative GTP-binding protein. AK097872 - Homo sapiens cDNA FLJ40553 fis, clone THYMU2002242, highly similar to Homo sapiens mRNA for GTP-binding protein. JD424289 - Sequence 405313 from Patent EP1572962. JD278094 - Sequence 259118 from Patent EP1572962. JD498485 - Sequence 479509 from Patent EP1572962. JD366131 - Sequence 347155 from Patent EP1572962. JD437823 - Sequence 418847 from Patent EP1572962. AK223412 - Homo sapiens mRNA for pseudoautosomal GTP-binding protein-like protein variant, clone: FCC109C11. JD396630 - Sequence 377654 from Patent EP1572962. JD077881 - Sequence 58905 from Patent EP1572962. JD515560 - Sequence 496584 from Patent EP1572962. KJ901867 - Synthetic construct Homo sapiens clone ccsbBroadEn_11261 GTPBP6 gene, encodes complete protein. BT007360 - Homo sapiens Pseudoautosomal GTP-binding protein-like mRNA, complete cds. AK298260 - Homo sapiens cDNA FLJ56805 complete cds, highly similar to Homo sapiens GTP binding protein 6 (GTPBP6), mRNA. AK296003 - Homo sapiens cDNA FLJ56662 complete cds, highly similar to Homo sapiens GTP binding protein 6 (GTPBP6), mRNA.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000326153.1, ENST00000326153.2, ENST00000326153.3, ENST00000326153.4, ENST00000326153.5, ENST00000326153.6, ENST00000326153.7, ENST00000326153.8, ENST00000326153.9, GTPB6_HUMAN, H0Y2S1, NM_012227, O43824, PGPL, Q53F77, Q5HYX8, uc317rzr.1, uc317rzr.2 UCSC ID: ENST00000326153.10_8 RefSeq Accession: NM_012227.4 Protein: O43824 (aka GTPB6_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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