Human Gene H1-10 (ENST00000333762.6_6) from GENCODE V47lift37
  Description: H1.10 linker histone (from RefSeq NM_006026.4)
Gencode Transcript: ENST00000333762.6_6
Gencode Gene: ENSG00000184897.7_10
Transcript (Including UTRs)
   Position: hg19 chr3:129,033,614-129,035,129 Size: 1,516 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr3:129,034,104-129,034,745 Size: 642 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:129,033,614-129,035,129)mRNA (may differ from genome)Protein (213 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: H1X_HUMAN
DESCRIPTION: RecName: Full=Histone H1x;
FUNCTION: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
SUBCELLULAR LOCATION: Nucleus. Chromosome.
TISSUE SPECIFICITY: Expressed ubiquitously.
SIMILARITY: Belongs to the histone H1/H5 family.
SIMILARITY: Contains 1 H15 (linker histone H1/H5 globular) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 142.74 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 3757.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -162.70384-0.424 Picture PostScript Text
3' UTR -219.30490-0.448 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005818 - Histone_H1/H5
IPR005819 - Histone_H5
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00538 - linker histone H1 and H5 family

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2LSO - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q92522
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0045296 cadherin binding

Biological Process:
GO:0006334 nucleosome assembly

Cellular Component:
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  BC010435 - Homo sapiens H1 histone family, member X, mRNA (cDNA clone MGC:15959 IMAGE:3538400), complete cds.
LF384151 - JP 2014500723-A/191654: Polycomb-Associated Non-Coding RNAs.
D64142 - Homo sapiens mRNA for histone H1x, complete cds.
BC000426 - Homo sapiens H1 histone family, member X, mRNA (cDNA clone MGC:8350 IMAGE:2819756), complete cds.
JD371489 - Sequence 352513 from Patent EP1572962.
JD406655 - Sequence 387679 from Patent EP1572962.
JD022115 - Sequence 3139 from Patent EP1572962.
JD030708 - Sequence 11732 from Patent EP1572962.
JD565326 - Sequence 546350 from Patent EP1572962.
JD445927 - Sequence 426951 from Patent EP1572962.
JD121060 - Sequence 102084 from Patent EP1572962.
LF363833 - JP 2014500723-A/171336: Polycomb-Associated Non-Coding RNAs.
JD047922 - Sequence 28946 from Patent EP1572962.
JD152537 - Sequence 133561 from Patent EP1572962.
JD387773 - Sequence 368797 from Patent EP1572962.
JD464973 - Sequence 445997 from Patent EP1572962.
MA619728 - JP 2018138019-A/191654: Polycomb-Associated Non-Coding RNAs.
MA599410 - JP 2018138019-A/171336: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000333762.1, ENST00000333762.2, ENST00000333762.3, ENST00000333762.4, ENST00000333762.5, H1-10 , H1FX , H1X_HUMAN, NM_006026, Q92522, uc317ttc.1, uc317ttc.2
UCSC ID: ENST00000333762.6_6
RefSeq Accession: NM_006026.4
Protein: Q92522 (aka H1X_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.