ID:HAT1_HUMAN DESCRIPTION: RecName: Full=Histone acetyltransferase type B catalytic subunit; EC=2.3.1.48; AltName: Full=Histone acetyltransferase 1; FUNCTION: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Catalytic subunit of the type B histone acetlytransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes. INTERACTION: P62805:HIST2H4B; NbExp=4; IntAct=EBI-2339359, EBI-302023; P12520:vpr (xeno); NbExp=3; IntAct=EBI-2339359, EBI-6164519; SUBCELLULAR LOCATION: Isoform A: Nucleus matrix. SUBCELLULAR LOCATION: Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein. DEVELOPMENTAL STAGE: Highly expressed in mitotic cells (at protein level). INDUCTION: Up-regulated by estrogen. SIMILARITY: Belongs to the HAT1 family. SEQUENCE CAUTION: Sequence=AAH18682.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Wikipedia; Note=Histone acetyltransferase entry; URL="http://en.wikipedia.org/wiki/Histone_acetyltransferase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14929
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
