ID:HAUS8_HUMAN DESCRIPTION: RecName: Full=HAUS augmin-like complex subunit 8; AltName: Full=HEC1/NDC80-interacting centrosome-associated protein 1; AltName: Full=Sarcoma antigen NY-SAR-48; FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. SUBUNIT: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. SIMILARITY: Belongs to the HAUS8 family. SEQUENCE CAUTION: Sequence=AAH10176.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO65172.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO65172.1; Type=Frameshift; Positions=222, 241, 269, 278, 279;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9BT25
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC004398 - Homo sapiens HEC1/NDC80 interacting, centrosome associated 1, mRNA (cDNA clone IMAGE:3636299), partial cds. BC040564 - Homo sapiens sarcoma antigen NY-SAR-48, mRNA (cDNA clone IMAGE:5266883), with apparent retained intron. AK295994 - Homo sapiens cDNA FLJ59027 complete cds, highly similar to Homo sapiens sarcoma antigen NY-SAR-48, transcript variant 1, mRNA. AY211919 - Homo sapiens sarcoma antigen NY-SAR-48 mRNA, partial cds. BC010176 - Homo sapiens HEC1/NDC80 interacting, centrosome associated 1, mRNA (cDNA clone MGC:20533 IMAGE:3342874), complete cds. KJ903600 - Synthetic construct Homo sapiens clone ccsbBroadEn_12994 HAUS8 gene, encodes complete protein. CU679649 - Synthetic construct Homo sapiens gateway clone IMAGE:100023323 5' read NY-SAR-48 mRNA. AK130803 - Homo sapiens cDNA FLJ27293 fis, clone TMS02941.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BT25 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
