ID:HCLS1_HUMAN DESCRIPTION: RecName: Full=Hematopoietic lineage cell-specific protein; AltName: Full=Hematopoietic cell-specific LYN substrate 1; AltName: Full=LckBP1; AltName: Full=p75; FUNCTION: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. SUBUNIT: Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54 (By similarity). SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion (Probable). TISSUE SPECIFICITY: Expressed only in tissues and cells of hematopoietic origin. DEVELOPMENTAL STAGE: Expressed in early stage of myeloid and erythroid differentiation. PTM: Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. SIMILARITY: Contains 4 cortactin repeats. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14317
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006355 regulation of transcription, DNA-templated GO:0008284 positive regulation of cell proliferation GO:0009725 response to hormone GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0030041 actin filament polymerization GO:0030218 erythrocyte differentiation GO:0030833 regulation of actin filament polymerization GO:0030854 positive regulation of granulocyte differentiation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0035556 intracellular signal transduction GO:0042307 positive regulation of protein import into nucleus GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0045651 positive regulation of macrophage differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051897 positive regulation of protein kinase B signaling GO:0071345 cellular response to cytokine stimulus GO:2000107 negative regulation of leukocyte apoptotic process GO:2000251 positive regulation of actin cytoskeleton reorganization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
