ID:HDAC2_HUMAN DESCRIPTION: RecName: Full=Histone deacetylase 2; Short=HD2; EC=3.5.1.98; FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. SUBUNIT: Component of a RCOR/GFI/KDM1A/HDAC complex. Interacts directly with GFI1 and GFI1B. Interacts with HDAC7, PRDM6, SAP30, SETDB1 and SUV39H1. Interacts with the H2AFY (via the non-histone region) (By similarity). Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Part of a complex containing the core histones H2A, H2B, H3 and H4, DEK and unphosphorylated DAXX. Part of a complex containing ATR and CHD4. Forms a heterologous complex at least with YY1. Interacts with ATR, CBFA2T3, DNMT1, MINT, HDAC10, HCFC1, NRIP1, KDM4A. and PELP1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3, ARID4B, HDAC1 and HDAC2. Interacts with CHFR and SAP30L. Interacts (CK2 phosphorylated form) with SP3. Interacts with TSHZ3 (via its N-terminus). Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. INTERACTION: Q9HCU9:BRMS1; NbExp=3; IntAct=EBI-301821, EBI-714781; Q9UER7:DAXX; NbExp=2; IntAct=EBI-301821, EBI-77321; P51610:HCFC1; NbExp=2; IntAct=EBI-301821, EBI-396176; Q13547:HDAC1; NbExp=5; IntAct=EBI-301821, EBI-301834; Q9UIS9:MBD1; NbExp=2; IntAct=EBI-301821, EBI-867196; P01106:MYC; NbExp=2; IntAct=EBI-301821, EBI-447544; P48382:RFX5; NbExp=4; IntAct=EBI-301821, EBI-923266; Q96ST3:SIN3A; NbExp=3; IntAct=EBI-301821, EBI-347218; O43463:SUV39H1; NbExp=3; IntAct=EBI-301821, EBI-349968; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed; lower levels in brain and lung. PTM: S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys- 262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching (By similarity). SIMILARITY: Belongs to the histone deacetylase family. HD type 1 subfamily. SEQUENCE CAUTION: Sequence=AAH31055.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG59420.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI14206.1; Type=Miscellaneous discrepancy; Note=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92769
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001103 RNA polymerase II repressing transcription factor binding GO:0003682 chromatin binding GO:0003723 RNA binding GO:0004407 histone deacetylase activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0016787 hydrolase activity GO:0019213 deacetylase activity GO:0019899 enzyme binding GO:0031072 heat shock protein binding GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding GO:0051059 NF-kappaB binding GO:1990841 promoter-specific chromatin binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0031492 nucleosomal DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001975 response to amphetamine GO:0003300 cardiac muscle hypertrophy GO:0006325 chromatin organization GO:0006338 chromatin remodeling GO:0006344 maintenance of chromatin silencing GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007596 blood coagulation GO:0008284 positive regulation of cell proliferation GO:0009913 epidermal cell differentiation GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010870 positive regulation of receptor biosynthetic process GO:0010977 negative regulation of neuron projection development GO:0016358 dendrite development GO:0016575 histone deacetylation GO:0031000 response to caffeine GO:0032496 response to lipopolysaccharide GO:0032732 positive regulation of interleukin-1 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032922 circadian regulation of gene expression GO:0032967 positive regulation of collagen biosynthetic process GO:0034605 cellular response to heat GO:0035094 response to nicotine GO:0042220 response to cocaine GO:0042475 odontogenesis of dentin-containing tooth GO:0042493 response to drug GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042733 embryonic digit morphogenesis GO:0043044 ATP-dependent chromatin remodeling GO:0043066 negative regulation of apoptotic process GO:0043392 negative regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045347 negative regulation of MHC class II biosynthetic process GO:0045862 positive regulation of proteolysis GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048149 behavioral response to ethanol GO:0048511 rhythmic process GO:0048714 positive regulation of oligodendrocyte differentiation GO:0055093 response to hyperoxia GO:0060789 hair follicle placode formation GO:0061000 negative regulation of dendritic spine development GO:0061029 eyelid development in camera-type eye GO:0061198 fungiform papilla formation GO:0070301 cellular response to hydrogen peroxide GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0071300 cellular response to retinoic acid GO:0071560 cellular response to transforming growth factor beta stimulus GO:1903351 cellular response to dopamine GO:2000757 negative regulation of peptidyl-lysine acetylation
BioCarta from NCI Cancer Genome Anatomy Project h_prc2Pathway - The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor h_etsPathway - METS affect on Macrophage Differentiation
Reactome (by CSHL, EBI, and GO)
Protein Q92769 (Reactome details) participates in the following event(s):
R-HSA-427409 Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA R-HSA-4616015 SUMOylation of HDAC2 with SUMO1 R-HSA-205056 PRDM4 inhibits cyclin E transcription R-HSA-5227490 NoRC:HDAC:DNMT methylates cytosine of the rRNA genes R-HSA-996727 REST recruits the BHC complex R-HSA-427404 Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene R-HSA-8943780 SALL4 recruits NuRD to PTEN gene R-HSA-1912388 NICD1 displaces co-repressor complex from RBPJ (CSL) R-HSA-2220982 NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) R-HSA-6805650 MTA2-NuRD complex deacetylates TP53 R-HSA-3769447 HDAC1/2 containing-complexes deacetylate histones R-HSA-6807077 NR2E1 associated with transcription repressors binds PTEN promoter R-HSA-427336 TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 R-HSA-5250941 Negative epigenetic regulation of rRNA expression R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-8943724 Regulation of PTEN gene transcription R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-212165 Epigenetic regulation of gene expression R-HSA-2990846 SUMOylation R-HSA-109582 Hemostasis R-HSA-5250913 Positive epigenetic regulation of rRNA expression R-HSA-6807070 PTEN Regulation R-HSA-6804758 Regulation of TP53 Activity through Acetylation R-HSA-73887 Death Receptor Signalling R-HSA-1980143 Signaling by NOTCH1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-74160 Gene expression (Transcription) R-HSA-597592 Post-translational protein modification R-HSA-3214815 HDACs deacetylate histones R-HSA-1257604 PIP3 activates AKT signaling R-HSA-5633007 Regulation of TP53 Activity R-HSA-162582 Signal Transduction R-HSA-157118 Signaling by NOTCH R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-392499 Metabolism of proteins R-HSA-3247509 Chromatin modifying enzymes R-HSA-9006925 Intracellular signaling by second messengers R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-5663202 Diseases of signal transduction R-HSA-4839726 Chromatin organization R-HSA-212436 Generic Transcription Pathway R-HSA-1643685 Disease R-HSA-73857 RNA Polymerase II Transcription
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
