ID:HDAC5_HUMAN DESCRIPTION: RecName: Full=Histone deacetylase 5; Short=HD5; EC=3.5.1.98; AltName: Full=Antigen NY-CO-9; FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. SUBUNIT: Interacts with AHRR (By similarity). Interacts with BAHD1, BCOR, HDAC7, HDAC9, CTBP1, MEF2C, NCOR2, NRIP1, PHB2 and a 14-3-3 chaperone protein. Interacts with KDM5B. Interacts with MYOCD (By similarity). Interacts with GRK5. Interacts with DDIT3/CHOP. INTERACTION: Q9HCU9:BRMS1; NbExp=2; IntAct=EBI-715576, EBI-714781; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity). PTM: Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm and inhibition. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylated by GRK5, leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription (By similarity). PTM: Ubiquitinated. Polyubiquitination however does not lead to its degradation. SIMILARITY: Belongs to the histone deacetylase family. HD type 2 subfamily. SEQUENCE CAUTION: Sequence=AAC18040.1; Type=Frameshift; Positions=1085; Sequence=BAA25526.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UQL6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF209369 - JP 2014500723-A/16872: Polycomb-Associated Non-Coding RNAs. BC011260 - Homo sapiens cDNA clone IMAGE:4156550. BC038423 - Homo sapiens, Similar to histone deacetylase 5, clone IMAGE:4933587, mRNA. BC041914 - Homo sapiens cDNA clone IMAGE:5299904. AB011172 - Homo sapiens mRNA for KIAA0600 protein, partial cds. AK093150 - Homo sapiens cDNA FLJ35831 fis, clone TESTI2006499. AX747956 - Sequence 1481 from Patent EP1308459. JD497989 - Sequence 479013 from Patent EP1572962. JD259273 - Sequence 240297 from Patent EP1572962. JD272343 - Sequence 253367 from Patent EP1572962. JD544295 - Sequence 525319 from Patent EP1572962. JD544294 - Sequence 525318 from Patent EP1572962. JD205702 - Sequence 186726 from Patent EP1572962. JD452878 - Sequence 433902 from Patent EP1572962. JD217096 - Sequence 198120 from Patent EP1572962. JD224353 - Sequence 205377 from Patent EP1572962. JD106123 - Sequence 87147 from Patent EP1572962. JD278288 - Sequence 259312 from Patent EP1572962. JD340386 - Sequence 321410 from Patent EP1572962. JD215999 - Sequence 197023 from Patent EP1572962. JD456493 - Sequence 437517 from Patent EP1572962. JD165017 - Sequence 146041 from Patent EP1572962. JD061825 - Sequence 42849 from Patent EP1572962. JD102468 - Sequence 83492 from Patent EP1572962. JD278941 - Sequence 259965 from Patent EP1572962. JD321875 - Sequence 302899 from Patent EP1572962. JD413220 - Sequence 394244 from Patent EP1572962. JD200571 - Sequence 181595 from Patent EP1572962. JD487623 - Sequence 468647 from Patent EP1572962. JD231739 - Sequence 212763 from Patent EP1572962. JD223344 - Sequence 204368 from Patent EP1572962. JD274622 - Sequence 255646 from Patent EP1572962. JD191522 - Sequence 172546 from Patent EP1572962. JD460256 - Sequence 441280 from Patent EP1572962. JD429282 - Sequence 410306 from Patent EP1572962. JD384567 - Sequence 365591 from Patent EP1572962. JD061787 - Sequence 42811 from Patent EP1572962. JD135353 - Sequence 116377 from Patent EP1572962. JD098308 - Sequence 79332 from Patent EP1572962. JD392115 - Sequence 373139 from Patent EP1572962. JD439674 - Sequence 420698 from Patent EP1572962. JD156047 - Sequence 137071 from Patent EP1572962. JD320308 - Sequence 301332 from Patent EP1572962. JD166991 - Sequence 148015 from Patent EP1572962. JD525119 - Sequence 506143 from Patent EP1572962. JD460999 - Sequence 442023 from Patent EP1572962. JD498404 - Sequence 479428 from Patent EP1572962. JD287493 - Sequence 268517 from Patent EP1572962. JD216355 - Sequence 197379 from Patent EP1572962. JD194429 - Sequence 175453 from Patent EP1572962. JD443781 - Sequence 424805 from Patent EP1572962. JD227442 - Sequence 208466 from Patent EP1572962. JD548452 - Sequence 529476 from Patent EP1572962. JD188305 - Sequence 169329 from Patent EP1572962. JD269153 - Sequence 250177 from Patent EP1572962. JD555762 - Sequence 536786 from Patent EP1572962. JD134860 - Sequence 115884 from Patent EP1572962. JD232506 - Sequence 213530 from Patent EP1572962. JD498047 - Sequence 479071 from Patent EP1572962. JD459919 - Sequence 440943 from Patent EP1572962. JD255297 - Sequence 236321 from Patent EP1572962. JD228717 - Sequence 209741 from Patent EP1572962. JD106221 - Sequence 87245 from Patent EP1572962. BC013140 - Homo sapiens, clone IMAGE:3867625, mRNA, partial cds. BC051824 - Homo sapiens histone deacetylase 5, mRNA (cDNA clone MGC:60081 IMAGE:6043491), complete cds. AB177853 - Homo sapiens mRNA for KIAA0600 splice variant 1. AF039691 - Homo sapiens antigen NY-CO-9 (NY-CO-9) mRNA, partial cds. AF132608 - Homo sapiens histone deacetylase 5 mRNA, complete cds. AB463070 - Synthetic construct DNA, clone: pF1KA0600, Homo sapiens HDAC5 gene for histone deacetylase 5, without stop codon, in Flexi system. AK075095 - Homo sapiens cDNA FLJ90614 fis, clone PLACE1002080, highly similar to Homo sapiens antigen NY-CO-9 (NY-CO-9) mRNA. AK027734 - Homo sapiens cDNA FLJ14828 fis, clone OVARC1000915, highly similar to Homo sapiens histone deacetylase 5 mRNA. AK294760 - Homo sapiens cDNA FLJ61241 complete cds, highly similar to Histone deacetylase 5. DQ575443 - Homo sapiens piRNA piR-43555, complete sequence. JD368719 - Sequence 349743 from Patent EP1572962. JD128473 - Sequence 109497 from Patent EP1572962. JD228768 - Sequence 209792 from Patent EP1572962. JD408602 - Sequence 389626 from Patent EP1572962. JD151785 - Sequence 132809 from Patent EP1572962. JD200359 - Sequence 181383 from Patent EP1572962. JD458584 - Sequence 439608 from Patent EP1572962. JD272545 - Sequence 253569 from Patent EP1572962. JD200362 - Sequence 181386 from Patent EP1572962. MA444946 - JP 2018138019-A/16872: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor h_pgc1aPathway - Regulation of PGC-1a h_etsPathway - METS affect on Macrophage Differentiation
Reactome (by CSHL, EBI, and GO)
Protein Q9UQL6 (Reactome details) participates in the following event(s):
R-HSA-1912388 NICD1 displaces co-repressor complex from RBPJ (CSL) R-HSA-2220982 NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) R-HSA-6807077 NR2E1 associated with transcription repressors binds PTEN promoter R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-1980143 Signaling by NOTCH1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-8943724 Regulation of PTEN gene transcription R-HSA-157118 Signaling by NOTCH R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-6807070 PTEN Regulation R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1643685 Disease R-HSA-9006925 Intracellular signaling by second messengers
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
