ID:HDAC9_HUMAN DESCRIPTION: RecName: Full=Histone deacetylase 9; Short=HD9; EC=3.5.1.98; AltName: Full=Histone deacetylase 7B; Short=HD7; Short=HD7b; AltName: Full=Histone deacetylase-related protein; AltName: Full=MEF2-interacting transcription repressor MITR; FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. ENZYME REGULATION: Inhibited by Trichostatin A (TSA) and suberoylanilide hydroxamic acid. SUBUNIT: Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3 (By similarity). Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6. INTERACTION: P41182:BCL6; NbExp=2; IntAct=EBI-765444, EBI-765407; P41212:ETV6; NbExp=3; IntAct=EBI-765476, EBI-1372759; Q60974:Ncor1 (xeno); NbExp=2; IntAct=EBI-765476, EBI-349004; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level). PTM: Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3- binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. PTM: Sumoylated. DISEASE: Note=A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein. SIMILARITY: Belongs to the histone deacetylase family. HD type 2 subfamily. SEQUENCE CAUTION: Sequence=BAA34464.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKV0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AJ459808 - Homo sapiens mRNA for histone decetylase 9b (HDAC9B gene). AY032738 - Homo sapiens histone deacetylase 9a (HDAC9) mRNA, complete cds, alternatively spliced. AY032737 - Homo sapiens histone deacetylase 9 (HDAC9) mRNA, complete cds, alternatively spliced. AY197371 - Homo sapiens histone deacetylase 9 (HDAC9) mRNA, complete cds; alternatively spliced. BC111735 - Homo sapiens histone deacetylase 9, mRNA (cDNA clone IMAGE:40036015), partial cds. AK095820 - Homo sapiens cDNA FLJ38501 fis, clone HCHON1000176, moderately similar to Histone deacetylase 5. AK304298 - Homo sapiens cDNA FLJ55607 complete cds, highly similar to Histone deacetylase 9. AK097178 - Homo sapiens cDNA FLJ39859 fis, clone SPLEN2015094, moderately similar to Mus musculus histone deacetylase mHDA1 mRNA. BC150328 - Homo sapiens histone deacetylase 9, mRNA (cDNA clone MGC:167816 IMAGE:8860495), complete cds. AB018287 - Homo sapiens KIAA0744 mRNA for KIAA0744 protein. BC152405 - Homo sapiens histone deacetylase 9, mRNA (cDNA clone MGC:176629 IMAGE:8862508), complete cds. AK297404 - Homo sapiens cDNA FLJ61317 complete cds, highly similar to Histone deacetylase 9. AK316109 - Homo sapiens cDNA, FLJ79008 complete cds, highly similar to Histone deacetylase 9. AY429540 - Homo sapiens HDAC9v_1 mRNA sequence; alternatively spliced. AK296214 - Homo sapiens cDNA FLJ53343 complete cds, highly similar to Histone deacetylase 9. CR749550 - Homo sapiens mRNA; cDNA DKFZp779K1053 (from clone DKFZp779K1053). EU832248 - Synthetic construct Homo sapiens clone HAIB:100067277; DKFZo004F0926 histone deacetylase 9 protein (HDAC9) gene, encodes complete protein. EU832154 - Synthetic construct Homo sapiens clone HAIB:100067183; DKFZo008F0925 histone deacetylase 9 protein (HDAC9) gene, encodes complete protein. AB385379 - Synthetic construct DNA, clone: pF1KA0744, Homo sapiens HDAC9 gene for histone deacetylase 9, complete cds, without stop codon, in Flexi system. EU832247 - Synthetic construct Homo sapiens clone HAIB:100067276; DKFZo004F0826 histone deacetylase 9 protein (HDAC9) gene, encodes complete protein. AK304410 - Homo sapiens cDNA FLJ54580 complete cds, highly similar to Histone deacetylase 9. AK304343 - Homo sapiens cDNA FLJ54577 complete cds, highly similar to Histone deacetylase 9. AF124924 - Homo sapiens histone deacetylase HDAC7 (HDAC7) mRNA, partial cds. BC092441 - Homo sapiens cDNA clone IMAGE:30411148. JD483634 - Sequence 464658 from Patent EP1572962. JD436275 - Sequence 417299 from Patent EP1572962. JD205674 - Sequence 186698 from Patent EP1572962. JD360021 - Sequence 341045 from Patent EP1572962. JD339782 - Sequence 320806 from Patent EP1572962. JD383235 - Sequence 364259 from Patent EP1572962. JD301809 - Sequence 282833 from Patent EP1572962. JD123005 - Sequence 104029 from Patent EP1572962. JD392056 - Sequence 373080 from Patent EP1572962. JD429236 - Sequence 410260 from Patent EP1572962. JD358135 - Sequence 339159 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_ranbp2Pathway - Sumoylation by RanBP2 Regulates Transcriptional Repression h_MITRPathway - Signal Dependent Regulation of Myogenesis by Corepressor MITR
Reactome (by CSHL, EBI, and GO)
Protein Q9UKV0 (Reactome details) participates in the following event(s):
R-HSA-1912388 NICD1 displaces co-repressor complex from RBPJ (CSL) R-HSA-2220982 NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-1980143 Signaling by NOTCH1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-157118 Signaling by NOTCH R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
