Human Gene HDC (ENST00000267845.8_7) from GENCODE V47lift37
  Description: histidine decarboxylase, transcript variant 1 (from RefSeq NM_002112.4)
Gencode Transcript: ENST00000267845.8_7
Gencode Gene: ENSG00000140287.11_9
Transcript (Including UTRs)
   Position: hg19 chr15:50,534,144-50,557,923 Size: 23,780 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr15:50,534,457-50,557,820 Size: 23,364 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:50,534,144-50,557,923)mRNA (may differ from genome)Protein (662 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DCHS_HUMAN
DESCRIPTION: RecName: Full=Histidine decarboxylase; Short=HDC; EC=4.1.1.22;
FUNCTION: Catalyzes the biosynthesis of histamine from histidine.
CATALYTIC ACTIVITY: L-histidine = histamine + CO(2).
COFACTOR: Pyridoxal phosphate.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.1 mM for histidine; Vmax=1880 nmol/min/mg enzyme;
PATHWAY: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.
SUBUNIT: Homodimer.
SIMILARITY: Belongs to the group II decarboxylase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HDC
Diseases sorted by gene-association score: gilles de la tourette syndrome* (676), mast cell neoplasm (16), stomach disease (10), systemic mastocytosis (9), pyloric stenosis (7), indolent systemic mastocytosis (7), fish allergy (7), tic disorder (6), intestinal obstruction (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.36 RPKM in Stomach
Total median expression: 64.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.60103-0.297 Picture PostScript Text
3' UTR -89.90313-0.287 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010977 - Aromatic_deC
IPR002129 - PyrdxlP-dep_de-COase
IPR015424 - PyrdxlP-dep_Trfase_major_dom
IPR015421 - PyrdxlP-dep_Trfase_major_sub1
IPR015422 - PyrdxlP-dep_Trfase_major_sub2
IPR021115 - Pyridoxal-P_BS

Pfam Domains:
PF00282 - Pyridoxal-dependent decarboxylase conserved domain

SCOP Domains:
53383 - PLP-dependent transferases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
4E1O - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P19113
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004398 histidine decarboxylase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding

Biological Process:
GO:0001694 histamine biosynthetic process
GO:0006520 cellular amino acid metabolic process
GO:0006547 histidine metabolic process
GO:0006548 histidine catabolic process
GO:0019752 carboxylic acid metabolic process
GO:0042423 catecholamine biosynthetic process

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK027221 - Homo sapiens cDNA: FLJ23568 fis, clone LNG11092, highly similar to HUMHDC Human histidine decarboxylase (HDC) mRNA.
M60445 - Human histidine decarboxylase (HDC) mRNA, complete cds.
X54297 - Human mRNA for histidine decarboxylase (EC 4.1.1.22).
JD187750 - Sequence 168774 from Patent EP1572962.
BC144173 - Homo sapiens histidine decarboxylase, mRNA (cDNA clone MGC:177710 IMAGE:9052693), complete cds.
BC130527 - Homo sapiens histidine decarboxylase, mRNA (cDNA clone MGC:163399 IMAGE:40146558), complete cds.
JD044048 - Sequence 25072 from Patent EP1572962.
JD246050 - Sequence 227074 from Patent EP1572962.
JD509461 - Sequence 490485 from Patent EP1572962.
HQ258478 - Synthetic construct Homo sapiens clone IMAGE:100072907 histidine decarboxylase (HDC) gene, encodes complete protein.
KJ896963 - Synthetic construct Homo sapiens clone ccsbBroadEn_06357 HDC gene, encodes complete protein.
AK310479 - Homo sapiens cDNA, FLJ17521.
AK308833 - Homo sapiens cDNA, FLJ98874.
AK311072 - Homo sapiens cDNA, FLJ18114.
JD251549 - Sequence 232573 from Patent EP1572962.
JD195632 - Sequence 176656 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6173 - histamine biosynthesis

Reactome (by CSHL, EBI, and GO)

Protein P19113 (Reactome details) participates in the following event(s):

R-HSA-977301 Histidine is decarboxylated to histamine
R-HSA-70921 Histidine catabolism
R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A1L4G0, B7ZM01, DCHS_HUMAN, ENST00000267845.1, ENST00000267845.2, ENST00000267845.3, ENST00000267845.4, ENST00000267845.5, ENST00000267845.6, ENST00000267845.7, NM_002112, P19113, uc317ilq.1, uc317ilq.2
UCSC ID: ENST00000267845.8_7
RefSeq Accession: NM_002112.4
Protein: P19113 (aka DCHS_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.