ID:HEBP1_HUMAN DESCRIPTION: RecName: Full=Heme-binding protein 1; AltName: Full=p22HBP; FUNCTION: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. DOMAIN: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity). SIMILARITY: Belongs to the HEBP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NRV9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC016277 - Homo sapiens heme binding protein 1, mRNA (cDNA clone MGC:8738 IMAGE:3907035), complete cds. AF117615 - Homo sapiens heme-binding protein (HBP) mRNA, complete cds. JD086685 - Sequence 67709 from Patent EP1572962. AK289877 - Homo sapiens cDNA FLJ75999 complete cds, highly similar to Homo sapiens heme binding protein 1 (HEBP1), mRNA. JD046616 - Sequence 27640 from Patent EP1572962. JD526012 - Sequence 507036 from Patent EP1572962. JD088143 - Sequence 69167 from Patent EP1572962. AF167473 - Homo sapiens heme-binding protein mRNA, complete cds. BT007294 - Homo sapiens heme binding protein 1 mRNA, complete cds. DQ892338 - Synthetic construct clone IMAGE:100004968; FLH185462.01X; RZPDo839B06148D heme binding protein 1 (HEBP1) gene, encodes complete protein. DQ895543 - Synthetic construct Homo sapiens clone IMAGE:100010003; FLH185458.01L; RZPDo839B06147D heme binding protein 1 (HEBP1) gene, encodes complete protein. JD019714 - Sequence 738 from Patent EP1572962. JD321512 - Sequence 302536 from Patent EP1572962. JD422352 - Sequence 403376 from Patent EP1572962. JD156820 - Sequence 137844 from Patent EP1572962. JD129052 - Sequence 110076 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NRV9 (Reactome details) participates in the following event(s):
R-HSA-444476 FPRL2 receptor binds a wide range of ligands R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-418594 G alpha (i) signalling events R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
