ID:HHIP_HUMAN DESCRIPTION: RecName: Full=Hedgehog-interacting protein; Short=HHIP; Short=HIP; Flags: Precursor; FUNCTION: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. SUBUNIT: Interacts with all three hedgehog family members, SHH, IHH and DHH. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity). Secreted (By similarity). Note=The last 22 C- terminal amino acids may participate in cell membrane attachment. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm (Probable). TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. DOMAIN: A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding. POLYMORPHISM: Genetic variations in HHIP define the stature quantitative trait locus 12 (STQTL12) [MIM:612226]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits. SIMILARITY: Belongs to the HHIP family. SIMILARITY: Contains 2 EGF-like domains. SEQUENCE CAUTION: Sequence=BAB14945.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96QV1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
