ID:HINFP_HUMAN DESCRIPTION: RecName: Full=Histone H4 transcription factor; AltName: Full=Histone nuclear factor P; Short=HiNF-P; AltName: Full=MBD2-interacting zinc finger protein; AltName: Full=Methyl-CpG-binding protein 2-interacting zinc finger protein; FUNCTION: Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. SUBUNIT: Binds MBD2 and a histone deacetylase complex. Interacts with NPAT. SUBCELLULAR LOCATION: Nucleus. Note=Associated with discrete nuclear foci. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver. PTM: Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation. SIMILARITY: Contains 9 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BQA5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0005515 protein binding GO:0019899 enzyme binding GO:0042393 histone binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001701 in utero embryonic development GO:0006281 DNA repair GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0010468 regulation of gene expression GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0045184 establishment of protein localization GO:0045445 myoblast differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
