Human Gene HIPK4 (ENST00000291823.3_7) from GENCODE V47lift37
  Description: homeodomain interacting protein kinase 4 (from RefSeq NM_144685.5)
Gencode Transcript: ENST00000291823.3_7
Gencode Gene: ENSG00000160396.9_9
Transcript (Including UTRs)
   Position: hg19 chr19:40,885,178-40,896,088 Size: 10,911 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr19:40,885,494-40,895,809 Size: 10,316 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:40,885,178-40,896,088)mRNA (may differ from genome)Protein (616 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HIPK4_HUMAN
DESCRIPTION: RecName: Full=Homeodomain-interacting protein kinase 4; EC=2.7.11.1;
FUNCTION: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: Autophosphorylated (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=BAB71458.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.64 RPKM in Testis
Total median expression: 39.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -135.20279-0.485 Picture PostScript Text
3' UTR -100.80316-0.319 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q8NE63
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0046777 protein autophosphorylation
GO:1901796 regulation of signal transduction by p53 class mediator

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC034501 - Homo sapiens homeodomain interacting protein kinase 4, mRNA (cDNA clone MGC:26964 IMAGE:4823304), complete cds.
AK302301 - Homo sapiens cDNA FLJ51391 complete cds, highly similar to Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).
AK057380 - Homo sapiens cDNA FLJ32818 fis, clone TESTI2002912, weakly similar to DUAL-SPECIFICITY TYROSINE-(Y)-PHOSPHORYLATION REGULATED KINASE (EC 2.7.1.-).
AK292228 - Homo sapiens cDNA FLJ75899 complete cds, highly similar to Homo sapiens homeodomain interacting protein kinase 4 (HIPK4), mRNA.
AK301713 - Homo sapiens cDNA FLJ53935 complete cds, highly similar to Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).
HM005400 - Homo sapiens clone HTL-T-87 testicular tissue protein Li 87 mRNA, complete cds.
KJ905619 - Synthetic construct Homo sapiens clone ccsbBroadEn_15258 HIPK4 gene, encodes complete protein.
JD228133 - Sequence 209157 from Patent EP1572962.
JD276328 - Sequence 257352 from Patent EP1572962.
JD462008 - Sequence 443032 from Patent EP1572962.
JD392882 - Sequence 373906 from Patent EP1572962.
JD523171 - Sequence 504195 from Patent EP1572962.
JD155688 - Sequence 136712 from Patent EP1572962.
JD397180 - Sequence 378204 from Patent EP1572962.
JD218288 - Sequence 199312 from Patent EP1572962.
JD231814 - Sequence 212838 from Patent EP1572962.
JD462413 - Sequence 443437 from Patent EP1572962.
JD077343 - Sequence 58367 from Patent EP1572962.
JD334928 - Sequence 315952 from Patent EP1572962.
JD108266 - Sequence 89290 from Patent EP1572962.
JD438453 - Sequence 419477 from Patent EP1572962.
JD221800 - Sequence 202824 from Patent EP1572962.
JD220186 - Sequence 201210 from Patent EP1572962.
JD148074 - Sequence 129098 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K863, ENST00000291823.1, ENST00000291823.2, HIPK4_HUMAN, NM_144685, Q8NE63, Q96M54, uc317kzh.1, uc317kzh.2
UCSC ID: ENST00000291823.3_7
RefSeq Accession: NM_144685.5
Protein: Q8NE63 (aka HIPK4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.