Human Gene H2AC8 (ENST00000303910.5_4) from GENCODE V47lift37
  Description: H2A clustered histone 8 (from RefSeq NM_021052.4)
Gencode Transcript: ENST00000303910.5_4
Gencode Gene: ENSG00000277075.4_9
Transcript (Including UTRs)
   Position: hg19 chr6:26,217,149-26,217,665 Size: 517 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr6:26,217,203-26,217,595 Size: 393 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:26,217,149-26,217,665)mRNA (may differ from genome)Protein (130 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q08AJ9_HUMAN
DESCRIPTION: RecName: Full=Histone H2A;
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the histone H2A family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.6054-0.178 Picture PostScript Text
3' UTR -15.2070-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009072 - Histone-fold
IPR007125 - Histone_core_D
IPR002119 - Histone_H2A

Pfam Domains:
PF00125 - Core histone H2A/H2B/H3/H4
PF16211 - C-terminus of histone H2A

SCOP Domains:
47113 - Histone-fold

ModBase Predicted Comparative 3D Structure on Q08AJ9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity

Cellular Component:
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome


-  Descriptions from all associated GenBank mRNAs
  AK311824 - Homo sapiens cDNA, FLJ92085, Homo sapiens histone 1, H2ae (HIST1H2AE), mRNA.
BC093836 - Homo sapiens histone cluster 1, H2ae, mRNA (cDNA clone MGC:120871 IMAGE:7939681), complete cds.
BC093862 - Homo sapiens histone cluster 1, H2ae, mRNA (cDNA clone MGC:120897 IMAGE:7939707), complete cds.
EU446964 - Synthetic construct Homo sapiens clone IMAGE:100069967; IMAGE:100012173; FLH257117.01L histone cluster 1, H2ae (HIST1H2AE) gene, encodes complete protein.
JD391734 - Sequence 372758 from Patent EP1572962.
JD252237 - Sequence 233261 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000303910.1, ENST00000303910.2, ENST00000303910.3, ENST00000303910.4, hCG_1640984 , hCG_1787383 , HIST1H2AB , HIST1H2AE , NM_021052, Q08AJ9, Q08AJ9_HUMAN, uc317nia.1, uc317nia.2
UCSC ID: ENST00000303910.5_4
RefSeq Accession: NM_021052.4
Protein: Q08AJ9

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.