Human Gene H4C7 (ENST00000611444.2_6) from GENCODE V47lift37

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Description: H4 clustered histone 7 (from RefSeq NM_003547.3)
Gencode Transcript: ENST00000611444.2_6
Gencode Gene: ENSG00000275663.2_8
Transcript (Including UTRs)
Position: hg19 chr6:26,246,839-26,247,224 Size: 386 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr6:26,246,909-26,247,205 Size: 297 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	Gene Alleles	Microarray Expression
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:26,246,839-26,247,224)			mRNA (may differ from genome)		Protein (98 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Table Schema	AlphaFold	BioGPS
Ensembl	Entrez Gene	ExonPrimer	GeneCards	MGI	OMIM
PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: H4G_HUMAN DESCRIPTION: RecName: Full=Histone H4-like protein type G; FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Chromosome (By similarity). SIMILARITY: Belongs to the histone H4 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	0.00	19	0.000	Picture	PostScript	Text
3' UTR	-23.80	70	-0.340	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009072 - Histone-fold
IPR007125 - Histone_core_D
IPR001951 - Histone_H4

SCOP Domains:
47113 - Histone-fold

ModBase Predicted Comparative 3D Structure on Q99525


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0003677 DNA binding GO:0005515 protein binding GO:0042393 histone binding GO:0046982 protein heterodimerization activity Biological Process: GO:0006334 nucleosome assembly GO:0008150 biological_process Cellular Component: GO:0000786 nucleosome GO:0000788 nuclear nucleosome GO:0005634 nucleus GO:0005694 chromosome

Descriptions from all associated GenBank mRNAs


	BC126276 - Homo sapiens histone cluster 1, H4g, mRNA (cDNA clone MGC:161554 IMAGE:8991992), complete cds. BC126278 - Homo sapiens histone cluster 1, H4g, mRNA (cDNA clone MGC:161556 IMAGE:8991994), complete cds. HQ258035 - Synthetic construct Homo sapiens clone IMAGE:100072344 histone cluster 1, H4g (HIST1H4G) gene, encodes complete protein. KJ892523 - Synthetic construct Homo sapiens clone ccsbBroadEn_01917 HIST1H4G gene, encodes complete protein.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000611444.1, H4/L, H4C7 , H4FL, H4G_HUMAN, HIST1H4G , NM_003547, Q99525, uc327njb.1, uc327njb.2 UCSC ID: ENST00000611444.2_6 RefSeq Accession: NM_003547.3 Protein: Q99525 (aka H4G_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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