Human Gene H3-7 (ENST00000392948.5_7) from GENCODE V47lift37

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Human Gene H3-7 (ENST00000392948.5_7) from GENCODE V47lift37

Description: H3.7 histone (putative), transcript variant 1 (from RefSeq NM_001372105.2)
Gencode Transcript: ENST00000392948.5_7
Gencode Gene: ENSG00000273213.4_15
Transcript (Including UTRs)
Position: hg19 chr1:149,400,086-149,400,553 Size: 468 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr1:149,400,132-149,400,542 Size: 411 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	Gene Alleles	RNA-Seq Expression
RNA Structure	Protein Structure	Other Species	GO Annotations	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:149,400,086-149,400,553)			mRNA (may differ from genome)		Protein (136 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	MGI
PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q5TEC6_HUMAN DESCRIPTION: RecName: Full=Histone H3; SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). SIMILARITY: Belongs to the histone H3 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 5.46 RPKM in Ovary Total median expression: 34.98 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-9.30	46	-0.202	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009072 - Histone-fold
IPR007125 - Histone_core_D
IPR000164 - Histone_H3

Pfam Domains:
PF00125 - Core histone H2A/H2B/H3/H4

SCOP Domains:
47113 - Histone-fold

Protein Data Bank (PDB) 3-D Structure
MuPIT help

4H75 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q5TEC6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003677 DNA binding GO:0031492 nucleosomal DNA binding GO:0046982 protein heterodimerization activity Biological Process: GO:0006334 nucleosome assembly Cellular Component: GO:0000786 nucleosome GO:0005634 nucleus GO:0005694 chromosome

Other Names for This Gene


	Alternate Gene Symbols: ENST00000392948.1, ENST00000392948.2, ENST00000392948.3, ENST00000392948.4, H3-2, H3-7 , H37_HUMAN, HIST2H3PS2 , NM_001372105, Q5TEC6, uc318vmi.1, uc318vmi.2 UCSC ID: ENST00000392948.5_7 RefSeq Accession: NM_001372105.2 Protein: Q5TEC6

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.