ID:ZEP1_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 40; AltName: Full=Cirhin interaction protein; Short=CIRIP; AltName: Full=Gate keeper of apoptosis-activating protein; Short=GAAP; AltName: Full=Human immunodeficiency virus type I enhancer-binding protein 1; Short=HIV-EP1; AltName: Full=Major histocompatibility complex-binding protein 1; Short=MBP-1; AltName: Full=Positive regulatory domain II-binding factor 1; Short=PRDII-BF1; FUNCTION: This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. SUBUNIT: Interacts with CIRH1A. INTERACTION: P54253:ATXN1; NbExp=6; IntAct=EBI-722264, EBI-930964; O00555:CACNA1A; NbExp=2; IntAct=EBI-722264, EBI-766279; SUBCELLULAR LOCATION: Isoform 1: Nucleus. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus. INDUCTION: By mitogens and phorbol ester. DOMAIN: Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between. SIMILARITY: Contains 5 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=CAA35798.1; Type=Frameshift; Positions=Several; Sequence=CAH73909.1; Type=Erroneous gene model prediction; Sequence=CAH73982.1; Type=Erroneous gene model prediction; Sequence=CAI14768.1; Type=Erroneous gene model prediction; Sequence=CAI21070.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15822
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007165 signal transduction GO:0007275 multicellular organism development
X51435 - Human PRDII-BF1 gene for a DNA-binding protein. BC140816 - Homo sapiens human immunodeficiency virus type I enhancer binding protein 1, mRNA (cDNA clone MGC:176493 IMAGE:9021684), complete cds. AB527403 - Synthetic construct DNA, clone: pF1KE0298, Homo sapiens HIVEP1 gene for human immunodeficiency virus type I enhancer binding protein 1, without stop codon, in Flexi system. JD407293 - Sequence 388317 from Patent EP1572962. JD211180 - Sequence 192204 from Patent EP1572962. JD338075 - Sequence 319099 from Patent EP1572962. BC028111 - Homo sapiens human immunodeficiency virus type I enhancer binding protein 1, mRNA (cDNA clone IMAGE:5392565), partial cds. M32019 - Human DNA-binding protein (mbp-1) mRNA, complete cds. AK294338 - Homo sapiens cDNA FLJ57104 complete cds, highly similar to Zinc finger protein 40. AY673640 - Homo sapiens cirhin interaction protein (CIRIP) mRNA, partial cds. J05011 - Homo sapiens HIV-1 enhancer binding protein, partial cds. JD063674 - Sequence 44698 from Patent EP1572962. JD561527 - Sequence 542551 from Patent EP1572962. JD282237 - Sequence 263261 from Patent EP1572962. JD561682 - Sequence 542706 from Patent EP1572962. JD283516 - Sequence 264540 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
