ID:HLF_HUMAN DESCRIPTION: RecName: Full=Hepatic leukemia factor; SUBUNIT: Binds DNA specifically as homodimer or heterodimer with other PAR factors. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highly expressed in liver; lower levels in lung and kidney. INDUCTION: Accumulates according to a robust circadian rhythm (By similarity). DISEASE: Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3. SIMILARITY: Belongs to the bZIP family. PAR subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SEQUENCE CAUTION: Sequence=AAA58445.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HLFID47.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16534
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0035914 skeletal muscle cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048511 rhythmic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
