ID:HLTF_HUMAN DESCRIPTION: RecName: Full=Helicase-like transcription factor; EC=3.6.4.-; EC=6.3.2.-; AltName: Full=DNA-binding protein/plasminogen activator inhibitor 1 regulator; AltName: Full=HIP116; AltName: Full=RING finger protein 80; AltName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; AltName: Full=Sucrose nonfermenting protein 2-like 3; FUNCTION: Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Binds to SP1 and SP3 independent of DNA; the interaction with these transcriptional factors may be required for basal transcription of target genes. Interacts with PCNA; the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 and UBE2V2-UBE2N ubiquitin ligase complexes. Interacts with RAD18, SHPRH, UBE2V2 and UBE2N. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. MISCELLANEOUS: Subject to frequent epigenetic inactivation by promoter methylation in colon cancer. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SIMILARITY: Contains 1 RING-type zinc finger. CAUTION: In contrast with other SMARC proteins, there is currently no evidence that it associates with actin or actin related proteins. It may rather act as a sequence-specific DNA binding ATPase, whose precise function remains to be fully characterized.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14527
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003723 RNA binding GO:0003824 catalytic activity GO:0004386 helicase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0008270 zinc ion binding GO:0016740 transferase activity GO:0016787 hydrolase activity GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0016887 ATPase activity GO:0031625 ubiquitin protein ligase binding GO:0046872 metal ion binding GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0008152 metabolic process GO:0016567 protein ubiquitination GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
