ID:HM13_HUMAN DESCRIPTION: RecName: Full=Minor histocompatibility antigen H13; EC=3.4.23.-; AltName: Full=Intramembrane protease 1; Short=IMP-1; Short=IMPAS-1; Short=hIMP1; AltName: Full=Presenilin-like protein 3; AltName: Full=Signal peptide peptidase; FUNCTION: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. SUBUNIT: Interacts with RNF139. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla. DOMAIN: The first transmembrane domain may act as a type I signal anchor (By similarity). The PAL motif is required for normal active site conformation (By similarity). PTM: N-glycosylated. SIMILARITY: Belongs to the peptidase A22B family. SEQUENCE CAUTION: Sequence=AAQ13609.1; Type=Frameshift; Positions=320, 329, 330, 358; Sequence=BAC11138.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAI19152.1; Type=Erroneous gene model prediction; Sequence=CAI20173.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TCT9
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004190 aspartic-type endopeptidase activity GO:0005515 protein binding GO:0008233 peptidase activity GO:0016787 hydrolase activity GO:0031625 ubiquitin protein ligase binding GO:0042500 aspartic endopeptidase activity, intramembrane cleaving GO:0042803 protein homodimerization activity
Biological Process: GO:0006508 proteolysis GO:0033619 membrane protein proteolysis GO:0051289 protein homotetramerization GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol GO:0006509 membrane protein ectodomain proteolysis GO:0031293 membrane protein intracellular domain proteolysis
Cellular Component: GO:0005765 lysosomal membrane GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0005791 rough endoplasmic reticulum GO:0005886 plasma membrane GO:0009986 cell surface GO:0016020 membrane GO:0016021 integral component of membrane GO:0030660 Golgi-associated vesicle membrane GO:0036513 Derlin-1 retrotranslocation complex GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Descriptions from all associated GenBank mRNAs
KJ894840 - Synthetic construct Homo sapiens clone ccsbBroadEn_04234 HM13 gene, encodes complete protein. AK314410 - Homo sapiens cDNA, FLJ95190, Homo sapiens histocompatibility (minor) 13 (HM13), mRNA. BC008938 - Homo sapiens histocompatibility (minor) 13, mRNA (cDNA clone MGC:2423 IMAGE:2961249), complete cds. BC008959 - Homo sapiens histocompatibility (minor) 13, mRNA (cDNA clone MGC:4069 IMAGE:2961249), complete cds. AY169310 - Homo sapiens intramembrane protease isoform 2 (IMP1) mRNA, complete cds. AY169311 - Homo sapiens intramembrane protease isoform 1 (IMP1) mRNA, complete cds. AY169312 - Homo sapiens intramembrane protease isoform 3 (IMP1) mRNA, complete cds. AK075283 - Homo sapiens cDNA FLJ90802 fis, clone Y79AA1000226, highly similar to Minor histocompatibility antigen H13 (EC3.4.99.-). DQ168450 - Homo sapiens signal peptide peptidase beta mRNA, complete cds, alternatively spliced. AF172086 - Homo sapiens MSTP086 mRNA, complete cds. BC062595 - Homo sapiens histocompatibility (minor) 13, mRNA (cDNA clone MGC:74542 IMAGE:5245982), complete cds. AF483215 - Homo sapiens minor histocompatibility antigen H13 isoform 1 (H13) mRNA, complete cds. AJ345029 - Homo sapiens mRNA for presenilin-like protein 3 (PSL3 gene). AJ420895 - Homo sapiens mRNA for signal peptide peptidase (SPP gene). DQ896206 - Synthetic construct Homo sapiens clone IMAGE:100010666; FLH191168.01L; RZPDo839A0567D histocompatibility (minor) 13 (HM13) gene, encodes complete protein. CU687568 - Synthetic construct Homo sapiens gateway clone IMAGE:100021667 5' read HM13 mRNA. KU178790 - Homo sapiens histocompatibility 13 isoform 1 (HM13) mRNA, partial cds. KU178791 - Homo sapiens histocompatibility 13 isoform 2 (HM13) mRNA, complete cds, alternatively spliced. AF515663 - Homo sapiens putative presenilin-like aspartyl protease mRNA, complete cds. BC053868 - Homo sapiens cDNA clone IMAGE:5194843, **** WARNING: chimeric clone ****. AK074686 - Homo sapiens cDNA FLJ90205 fis, clone MAMMA1001957, highly similar to Minor histocompatibility antigen 13 isoform 4. JD196309 - Sequence 177333 from Patent EP1572962. AF075033 - Homo sapiens full length insert cDNA YN52F10. JD191853 - Sequence 172877 from Patent EP1572962. JD038020 - Sequence 19044 from Patent EP1572962. JD427194 - Sequence 408218 from Patent EP1572962. JD319000 - Sequence 300024 from Patent EP1572962. JD206582 - Sequence 187606 from Patent EP1572962. JD181969 - Sequence 162993 from Patent EP1572962. JD235634 - Sequence 216658 from Patent EP1572962. JD556802 - Sequence 537826 from Patent EP1572962. JD398555 - Sequence 379579 from Patent EP1572962. JD111485 - Sequence 92509 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
