ID:HMGB1_HUMAN DESCRIPTION: RecName: Full=High mobility group protein B1; AltName: Full=High mobility group protein 1; Short=HMG-1; FUNCTION: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). SUBUNIT: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity). SUBCELLULAR LOCATION: Nucleus. Chromosome. SIMILARITY: Belongs to the HMGB family. SIMILARITY: Contains 2 HMG box DNA-binding domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/hmgb1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09429
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK122825 - Homo sapiens cDNA FLJ16428 fis, clone BRACE3008066, highly similar to High mobility group protein B1. CR749614 - Homo sapiens mRNA; cDNA DKFZp686A04236 (from clone DKFZp686A04236). KJ896987 - Synthetic construct Homo sapiens clone ccsbBroadEn_06381 HMGB1 gene, encodes complete protein. JD197862 - Sequence 178886 from Patent EP1572962. JD212485 - Sequence 193509 from Patent EP1572962. JD112367 - Sequence 93391 from Patent EP1572962. JD212484 - Sequence 193508 from Patent EP1572962. JD542605 - Sequence 523629 from Patent EP1572962. JD222873 - Sequence 203897 from Patent EP1572962. JD497687 - Sequence 478711 from Patent EP1572962. JD497688 - Sequence 478712 from Patent EP1572962. JA482248 - Sequence 231 from Patent WO2011072091. JE980540 - Sequence 231 from Patent EP2862929. AL110194 - Homo sapiens mRNA; cDNA DKFZp566M063 (from clone DKFZp566M063). BC141844 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:166986 IMAGE:8860319), complete cds. AK057120 - Homo sapiens cDNA FLJ32558 fis, clone SPLEN1000143, highly similar to High mobility group protein B1. BC030981 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:32637 IMAGE:4041682), complete cds. JD100653 - Sequence 81677 from Patent EP1572962. JD566758 - Sequence 547782 from Patent EP1572962. JD228297 - Sequence 209321 from Patent EP1572962. JD052614 - Sequence 33638 from Patent EP1572962. JD557206 - Sequence 538230 from Patent EP1572962. AK291494 - Homo sapiens cDNA FLJ77690 complete cds, highly similar to Homo sapiens high-mobility group box 1 (HMGB1), mRNA. L13804 - Homo sapiens (clone 06) liver expressed high mobility group 1 protein mRNA, 3' end. BC067732 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:86953 IMAGE:4818524), complete cds. BX647267 - Homo sapiens mRNA; cDNA DKFZp686N1099 (from clone DKFZp686N1099). D63874 - Homo sapiens FM1 mRNA for HMG-1, complete cds. AX795278 - Sequence 1 from Patent WO03051383. BC003378 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:5223 IMAGE:2901382), complete cds. JD551355 - Sequence 532379 from Patent EP1572962. LF337017 - JP 2014500723-A/144520: Polycomb-Associated Non-Coding RNAs. AF401215 - Homo sapiens HMG1 mRNA, 3' untranslated region. BC066889 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:86954 IMAGE:5268698), complete cds. AB208998 - Homo sapiens mRNA for high-mobility group box 1 variant protein. AK310975 - Homo sapiens cDNA, FLJ18017. JD297262 - Sequence 278286 from Patent EP1572962. X12597 - Human mRNA for high mobility group-1 protein (HMG-1). LF323756 - JP 2014500723-A/131259: Polycomb-Associated Non-Coding RNAs. JD307312 - Sequence 288336 from Patent EP1572962. JD299750 - Sequence 280774 from Patent EP1572962. L13805 - Homo sapiens (clone 06) high mobility group 1 protein mRNA fragment. JD283835 - Sequence 264859 from Patent EP1572962. AY377859 - Homo sapiens high mobility group protein 1 mRNA, complete cds. CR456863 - Homo sapiens full open reading frame cDNA clone RZPDo834D0816D for gene HMGB1, high-mobility group box 1; complete cds, incl. stopcodon. BT006940 - Homo sapiens high-mobility group box 1 mRNA, complete cds. BT020159 - Homo sapiens high-mobility group box 1 mRNA, complete cds. CU678446 - Synthetic construct Homo sapiens gateway clone IMAGE:100016790 5' read HMGB1 mRNA. CU688180 - Synthetic construct Homo sapiens gateway clone IMAGE:100021064 5' read HMGB1 mRNA. BC140013 - Synthetic construct Homo sapiens clone IMAGE:100000676, MGC:167158 high-mobility group box 1 (HMGB1) mRNA, encodes complete protein. BC140018 - Synthetic construct Homo sapiens clone IMAGE:100013567, MGC:167183 high-mobility group box 1 (HMGB1) mRNA, encodes complete protein. AB527489 - Synthetic construct DNA, clone: pF1KB7934, Homo sapiens HMGB1 gene for high-mobility group box 1, without stop codon, in Flexi system. LF317124 - JP 2014500723-A/124627: Polycomb-Associated Non-Coding RNAs. KX821210 - Homo sapiens isolate THM1 high mobility group box 1 (HMGB1) mRNA, partial cds. LF343553 - JP 2014500723-A/151056: Polycomb-Associated Non-Coding RNAs. LF343357 - JP 2014500723-A/150860: Polycomb-Associated Non-Coding RNAs. LF372070 - JP 2014500723-A/179573: Polycomb-Associated Non-Coding RNAs. LF361953 - JP 2014500723-A/169456: Polycomb-Associated Non-Coding RNAs. LF366776 - JP 2014500723-A/174279: Polycomb-Associated Non-Coding RNAs. LF370158 - JP 2014500723-A/177661: Polycomb-Associated Non-Coding RNAs. LF371918 - JP 2014500723-A/179421: Polycomb-Associated Non-Coding RNAs. LF365203 - JP 2014500723-A/172706: Polycomb-Associated Non-Coding RNAs. LF336970 - JP 2014500723-A/144473: Polycomb-Associated Non-Coding RNAs. LF343160 - JP 2014500723-A/150663: Polycomb-Associated Non-Coding RNAs. LF345325 - JP 2014500723-A/152828: Polycomb-Associated Non-Coding RNAs. LF343393 - JP 2014500723-A/150896: Polycomb-Associated Non-Coding RNAs. LF331940 - JP 2014500723-A/139443: Polycomb-Associated Non-Coding RNAs. LF317744 - JP 2014500723-A/125247: Polycomb-Associated Non-Coding RNAs. LF317125 - JP 2014500723-A/124628: Polycomb-Associated Non-Coding RNAs. LF325343 - JP 2014500723-A/132846: Polycomb-Associated Non-Coding RNAs. AK304506 - Homo sapiens cDNA FLJ56337 complete cds, highly similar to High mobility group protein B1. LF323755 - JP 2014500723-A/131258: Polycomb-Associated Non-Coding RNAs. LF361954 - JP 2014500723-A/169457: Polycomb-Associated Non-Coding RNAs. LF366040 - JP 2014500723-A/173543: Polycomb-Associated Non-Coding RNAs. KX821209 - Homo sapiens isolate CHM1 high mobility group box 1 (HMGB1) mRNA, partial cds. LF372071 - JP 2014500723-A/179574: Polycomb-Associated Non-Coding RNAs. LF334605 - JP 2014500723-A/142108: Polycomb-Associated Non-Coding RNAs. LF375440 - JP 2014500723-A/182943: Polycomb-Associated Non-Coding RNAs. JD343525 - Sequence 324549 from Patent EP1572962. JD484349 - Sequence 465373 from Patent EP1572962. MA559333 - JP 2018138019-A/131259: Polycomb-Associated Non-Coding RNAs. MA579130 - JP 2018138019-A/151056: Polycomb-Associated Non-Coding RNAs. MA578934 - JP 2018138019-A/150860: Polycomb-Associated Non-Coding RNAs. MA607647 - JP 2018138019-A/179573: Polycomb-Associated Non-Coding RNAs. MA602353 - JP 2018138019-A/174279: Polycomb-Associated Non-Coding RNAs. MA605735 - JP 2018138019-A/177661: Polycomb-Associated Non-Coding RNAs. MA607495 - JP 2018138019-A/179421: Polycomb-Associated Non-Coding RNAs. MA600780 - JP 2018138019-A/172706: Polycomb-Associated Non-Coding RNAs. MA578737 - JP 2018138019-A/150663: Polycomb-Associated Non-Coding RNAs. MA580902 - JP 2018138019-A/152828: Polycomb-Associated Non-Coding RNAs. MA578970 - JP 2018138019-A/150896: Polycomb-Associated Non-Coding RNAs. MA567517 - JP 2018138019-A/139443: Polycomb-Associated Non-Coding RNAs. MA560920 - JP 2018138019-A/132846: Polycomb-Associated Non-Coding RNAs. MA559332 - JP 2018138019-A/131258: Polycomb-Associated Non-Coding RNAs. MA601617 - JP 2018138019-A/173543: Polycomb-Associated Non-Coding RNAs. MA607648 - JP 2018138019-A/179574: Polycomb-Associated Non-Coding RNAs. MA572594 - JP 2018138019-A/144520: Polycomb-Associated Non-Coding RNAs. MA552701 - JP 2018138019-A/124627: Polycomb-Associated Non-Coding RNAs. MA597530 - JP 2018138019-A/169456: Polycomb-Associated Non-Coding RNAs. MA572547 - JP 2018138019-A/144473: Polycomb-Associated Non-Coding RNAs. MA553321 - JP 2018138019-A/125247: Polycomb-Associated Non-Coding RNAs. MA552702 - JP 2018138019-A/124628: Polycomb-Associated Non-Coding RNAs. MA597531 - JP 2018138019-A/169457: Polycomb-Associated Non-Coding RNAs. MA570182 - JP 2018138019-A/142108: Polycomb-Associated Non-Coding RNAs. MA611017 - JP 2018138019-A/182943: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_DNAfragmentPathway - Apoptotic DNA fragmentation and tissue homeostasis h_pcafpathway - The information-processing pathway at the IFN-beta enhancer
Reactome (by CSHL, EBI, and GO)
Protein P09429 (Reactome details) participates in the following event(s):