Human Gene HMMR (ENST00000393915.9_12) from GENCODE V47lift37

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Description: hyaluronan mediated motility receptor, transcript variant 1 (from RefSeq NM_001142556.2)
Gencode Transcript: ENST00000393915.9_12
Gencode Gene: ENSG00000072571.20_17
Transcript (Including UTRs)
Position: hg19 chr5:162,887,638-162,918,947 Size: 31,310 Total Exon Count: 18 Strand: +
Coding Region
Position: hg19 chr5:162,887,699-162,918,170 Size: 30,472 Coding Exon Count: 18

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:162,887,638-162,918,947)			mRNA (may differ from genome)		Protein (725 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: HMMR_HUMAN DESCRIPTION: RecName: Full=Hyaluronan mediated motility receptor; AltName: Full=Intracellular hyaluronic acid-binding protein; AltName: Full=Receptor for hyaluronan-mediated motility; AltName: CD_antigen=CD168; FUNCTION: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. SUBUNIT: Subunit of the HARC complex. SUBCELLULAR LOCATION: Cell surface. Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in breast cancer cell lines and in normal breast tissue.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: HMMR Diseases sorted by gene-association score: breast cancer* (129), fibrosarcoma (4), leukemia, acute myeloid (0) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D002945 Cisplatin D003300 Copper D003993 Dibutyl Phthalate D004317 Doxorubicin D013749 Tetrachlorodibenzodioxin C006253 pirinixic acid C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C010914 2,4-diaminotoluene C023514 2,6-dinitrotoluene C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D016604 Aflatoxin B1 D000643 Ammonium Chloride D001241 Aspirin D001564 Benzo(a)pyrene D002117 Calcitriol D002251 Carbon Tetrachloride D019327 Copper Sulfate D003375 Coumestrol D016572 Cyclosporine D004026 Dieldrin D004958 Estradiol D005419 Flavonoids D005472 Fluorouracil D005944 Glucosamine D006820 Hyaluronic Acid D006861 Hydrogen Peroxide C533894 LG 100815 D016912 Levonorgestrel D008154 Lucanthone D058185 Magnetite Nanoparticles D008748 Methylcholanthrene C558013 NSC 689534 D017239 Paclitaxel D010634 Phenobarbital D010894 Piroxicam D011285 Pregnenolone Carbonitrile D011374 Progesterone D011794 Quercetin D004113 Succimer D013467 Sulindac D013739 Testosterone D014028 Tobacco Smoke Pollution D014118 Toxins, Biological D014241 Trichloroethylene D014635 Valproic Acid D014747 Vinblastine D014750 Vincristine C000228 aristolochic acid I C044887 beta-methylcholine C002791 bismuth tripotassium dicitrate C006780 bisphenol A C018021 cobaltous chloride C488369 dasatinib C045651 epigallocatechin gallate C051890 irinotecan C011890 kojic acid C008261 lead acetate C017096 n-butoxyethanol C028007 nickel monoxide C062198 octa-2,4,6-trienoic acid C027373 potassium chromate(VI) C045950 propiconazole C059514 resveratrol C010792 testosterone undecanoate C015559 trimellitic anhydride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 22.94 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 51.33 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-15.90	61	-0.261	Picture	PostScript	Text
3' UTR	-158.00	777	-0.203	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026203 - IHABP

Pfam Domains:
PF15905 - Hyaluronan mediated motility receptor N-terminal
PF15908 - Hyaluronan mediated motility receptor C-terminal

SCOP Domains:
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on O75330


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0005540 hyaluronic acid binding Biological Process: GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0030214 hyaluronan catabolic process Cellular Component: GO:0005737 cytoplasm GO:0005813 centrosome GO:0005829 cytosol GO:0005886 plasma membrane GO:0009986 cell surface GO:0015630 microtubule cytoskeleton GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AY623426 - Homo sapiens hyaluronan-mediated motility receptor (HMMR) mRNA, complete sequence. LF384717 - JP 2014500723-A/192220: Polycomb-Associated Non-Coding RNAs. BC057235 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:6616448), partial cds. AK313603 - Homo sapiens cDNA, FLJ94172. BC030505 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:3919885), partial cds. BC006984 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:3997460), partial cds. AK302975 - Homo sapiens cDNA FLJ53375 complete cds, highly similar to Hyaluronan mediated motility receptor. AK303616 - Homo sapiens cDNA FLJ53429 complete cds, highly similar to Hyaluronan mediated motility receptor. BC070281 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:4063479), partial cds. BC017793 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone IMAGE:4698833), partial cds. U29343 - Homo sapiens hyaluronan receptor (RHAMM) mRNA, complete cds. AF032862 - Homo sapiens intracellular hyaluronic acid binding protein (IHABP) mRNA, complete cds. BC108904 - Homo sapiens hyaluronan-mediated motility receptor (RHAMM), mRNA (cDNA clone MGC:119494 IMAGE:40007903), complete cds. BC108905 - Homo sapiens cDNA clone IMAGE:40007904, containing frame-shift errors. BC107869 - Homo sapiens cDNA clone IMAGE:4724268, containing frame-shift errors. AK290577 - Homo sapiens cDNA FLJ75647 complete cds, highly similar to Homo sapiens hyaluronan-mediated motility receptor (RHAMM) (HMMR), transcript variant 2, mRNA. KJ901492 - Synthetic construct Homo sapiens clone ccsbBroadEn_10886 HMMR gene, encodes complete protein. KJ896989 - Synthetic construct Homo sapiens clone ccsbBroadEn_06383 HMMR gene, encodes complete protein. BC033568 - Homo sapiens, Similar to hyaluronan-mediated motility receptor (RHAMM), clone IMAGE:4777447, mRNA. LF325429 - JP 2014500723-A/132932: Polycomb-Associated Non-Coding RNAs. LF325428 - JP 2014500723-A/132931: Polycomb-Associated Non-Coding RNAs. LF325426 - JP 2014500723-A/132929: Polycomb-Associated Non-Coding RNAs. JD566406 - Sequence 547430 from Patent EP1572962. JD289217 - Sequence 270241 from Patent EP1572962. JD528654 - Sequence 509678 from Patent EP1572962. DM110835 - Novel Cancer Marker and Use Thereof. JD083463 - Sequence 64487 from Patent EP1572962. JD424540 - Sequence 405564 from Patent EP1572962. JD376952 - Sequence 357976 from Patent EP1572962. LF325425 - JP 2014500723-A/132928: Polycomb-Associated Non-Coding RNAs. MA620294 - JP 2018138019-A/192220: Polycomb-Associated Non-Coding RNAs. MA561006 - JP 2018138019-A/132932: Polycomb-Associated Non-Coding RNAs. MA561005 - JP 2018138019-A/132931: Polycomb-Associated Non-Coding RNAs. MA561003 - JP 2018138019-A/132929: Polycomb-Associated Non-Coding RNAs. MA561002 - JP 2018138019-A/132928: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O75330 (Reactome details) participates in the following event(s): R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-2160915 Receptor-mediated uptake of HA R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-2160884 HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ R-HSA-8854518 AURKA Activation by TPX2 R-HSA-2160916 Hyaluronan uptake and degradation R-HSA-69275 G2/M Transition R-HSA-2142845 Hyaluronan metabolism R-HSA-453274 Mitotic G2-G2/M phases R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-69278 Cell Cycle (Mitotic) R-HSA-71387 Metabolism of carbohydrates R-HSA-1640170 Cell Cycle R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: A8K3G2, B4E114, D3DQK9, D3DQL0, E9PCS0, ENST00000393915.1, ENST00000393915.2, ENST00000393915.3, ENST00000393915.4, ENST00000393915.5, ENST00000393915.6, ENST00000393915.7, ENST00000393915.8, HMMR_HUMAN, IHABP, NM_001142556, O75330, Q32N02, Q92767, RHAMM, uc318wfn.1, uc318wfn.2 UCSC ID: ENST00000393915.9_12 RefSeq Accession: NM_001142556.2 Protein: O75330 (aka HMMR_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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