Human Gene HMOX1 (ENST00000216117.9_4) from GENCODE V47lift37
  Description: heme oxygenase 1 (from RefSeq NM_002133.3)
Gencode Transcript: ENST00000216117.9_4
Gencode Gene: ENSG00000100292.18_8
Transcript (Including UTRs)
   Position: hg19 chr22:35,777,089-35,790,200 Size: 13,112 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr22:35,777,167-35,789,591 Size: 12,425 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:35,777,089-35,790,200)mRNA (may differ from genome)Protein (288 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HMOX1
Diseases sorted by gene-association score: heme oxygenase-1 deficiency* (1029), pulmonary disease, chronic obstructive* (554), toxic encephalopathy (24), central retinal artery occlusion (21), hepatopulmonary syndrome (18), arteriovenous fistula (15), neonatal jaundice (14), superficial siderosis (13), hemorrhagic cystitis (12), ischemia (10), pulmonary emphysema (10), retinal artery occlusion (9), protoporphyria, erythropoietic, autosomal recessive (8), renovascular hypertension (8), arteriosclerosis (8), mitochondrial cardiomyopathy (7), siderosis (7), brain edema (6), pulmonary edema (6), bilirubin metabolic disorder (6), mycobacterium abscessus (6), atherosclerosis (5), pneumothorax (5), severe hemophilia a (5), radiation cystitis (4), nodular malignant melanoma (4), mediastinal malignant lymphoma (4), malaria (4), vascular disease (4), mediastinal gray zone lymphoma (4), carrion's disease (4), hemochromatosis (3), central nervous system disease (2), parkinson disease, late-onset (2), macular degeneration, age-related, 1 (1), colorectal cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 515.60 RPKM in Spleen
Total median expression: 1287.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.3078-0.273 Picture PostScript Text
3' UTR -206.60609-0.339 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002051 - Haem_Oase
IPR016053 - Haem_Oase-like
IPR016084 - Haem_Oase-like_multi-hlx
IPR018207 - Haem_oxygenase_CS

Pfam Domains:
PF01126 - Heme oxygenase

SCOP Domains:
48613 - Heme oxygenase-like

ModBase Predicted Comparative 3D Structure on Q6FH11
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGD   SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004392 heme oxygenase (decyclizing) activity
GO:0004630 phospholipase D activity
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0046872 metal ion binding

Biological Process:
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0006788 heme oxidation
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0008217 regulation of blood pressure
GO:0008219 cell death
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0031670 cellular response to nutrient
GO:0032764 negative regulation of mast cell cytokine production
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035556 intracellular signal transduction
GO:0042167 heme catabolic process
GO:0042168 heme metabolic process
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043305 negative regulation of mast cell degranulation
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627 response to estrogen
GO:0045766 positive regulation of angiogenesis
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0055114 oxidation-reduction process
GO:0071243 cellular response to arsenic-containing substance
GO:0071276 cellular response to cadmium ion
GO:0072719 cellular response to cisplatin
GO:0097421 liver regeneration
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904706 negative regulation of vascular smooth muscle cell proliferation

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  CR456505 - Homo sapiens HMOX1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.HMOX1.V2).
X06985 - Human mRNA for heme oxygenase.
AK313120 - Homo sapiens cDNA, FLJ93605, highly similar to Homo sapiens heme oxygenase (decycling) 1 (HMOX1), mRNA.
BC001491 - Homo sapiens heme oxygenase (decycling) 1, mRNA (cDNA clone MGC:1723 IMAGE:3504480), complete cds.
M23041 - Homo sapiens (clone 2/10) heme oxygenase mRNA, 5' end of cds.
AB528477 - Synthetic construct DNA, clone: pF1KE0528, Homo sapiens HMOX1 gene for heme oxygenase (decycling) 1, without stop codon, in Flexi system.
CR541968 - Homo sapiens full open reading frame cDNA clone RZPDo834H0934D for gene HMOX1, heme oxygenase (decycling) 1; complete cds, without stopcodon.
CU013391 - Homo sapiens HMOX1, mRNA (cDNA clone IMAGE:100000266), complete cds, without stop codon, in Gateway system.
JF323038 - Homo sapiens heme oxygenase 1 (HMOX1) mRNA, partial cds.
BT019785 - Homo sapiens heme oxygenase (decycling) 1 mRNA, complete cds.
DQ892310 - Synthetic construct clone IMAGE:100004940; FLH185108.01X; RZPDo839F04146D heme oxygenase (decycling) 1 (HMOX1) gene, encodes complete protein.
DQ895510 - Synthetic construct Homo sapiens clone IMAGE:100009970; FLH185104.01L; RZPDo839F04145D heme oxygenase (decycling) 1 (HMOX1) gene, encodes complete protein.
KJ896990 - Synthetic construct Homo sapiens clone ccsbBroadEn_06384 HMOX1 gene, encodes complete protein.
CR541945 - Homo sapiens full open reading frame cDNA clone RZPDo834A1134D for gene HMOX1, heme oxygenase (decycling) 1; complete cds, incl. stopcodon.
CU013103 - Homo sapiens HMOX1, mRNA (cDNA clone IMAGE:100000362), complete cds, with stop codon, in Gateway system.
AF051791 - Homo sapiens heme oxygenase 1-like mRNA sequence.
GU187011 - Homo sapiens clone upstream1 HMOX1 (HMOX1) mRNA, partial cds.
GU187012 - Homo sapiens clone upstream2 HMOX1 (HMOX1) mRNA, partial cds.
JD511315 - Sequence 492339 from Patent EP1572962.
JD414418 - Sequence 395442 from Patent EP1572962.
JD458457 - Sequence 439481 from Patent EP1572962.
JD129569 - Sequence 110593 from Patent EP1572962.
JD285892 - Sequence 266916 from Patent EP1572962.
M23042 - Homo sapiens (clones 2/10, 1/149 and 1/4) heme oxygenase mRNA, 3'UTR.
JD517158 - Sequence 498182 from Patent EP1572962.
JD484848 - Sequence 465872 from Patent EP1572962.
JD134700 - Sequence 115724 from Patent EP1572962.
JD372055 - Sequence 353079 from Patent EP1572962.
JD072627 - Sequence 53651 from Patent EP1572962.
JD274512 - Sequence 255536 from Patent EP1572962.
JD563055 - Sequence 544079 from Patent EP1572962.
JD291320 - Sequence 272344 from Patent EP1572962.
JD185725 - Sequence 166749 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-5874 - heme degradation I

BioCarta from NCI Cancer Genome Anatomy Project
h_il10Pathway - IL-10 Anti-inflammatory Signaling Pathway
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000216117.1, ENST00000216117.2, ENST00000216117.3, ENST00000216117.4, ENST00000216117.5, ENST00000216117.6, ENST00000216117.7, ENST00000216117.8, hCG_40033 , HMOX1 , NM_002133, Q6FH11, Q6FH11_HUMAN, uc317col.1, uc317col.2
UCSC ID: ENST00000216117.9_4
RefSeq Accession: NM_002133.3
Protein: Q6FH11

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.