The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
X71346 - Homo sapiens HNF1-B mRNA. HM116541 - Homo sapiens HNF1 alpha A splice variant 1 (HNF1A) mRNA, complete cds, alternatively spliced. HM116542 - Homo sapiens HNF1 alpha A splice variant 2 (HNF1A) mRNA, complete cds, alternatively spliced. HM116543 - Homo sapiens HNF1 alpha A splice variant 3 (HNF1A) mRNA, complete cds, alternatively spliced. HM116544 - Homo sapiens HNF1 alpha A splice variant 4 (HNF1A) mRNA, complete cds, alternatively spliced. HM116545 - Homo sapiens HNF1 alpha A splice variant 5 (HNF1A) mRNA, complete cds, alternatively spliced. HM116546 - Homo sapiens HNF1 alpha A splice variant 6 (HNF1A) mRNA, complete cds, alternatively spliced. HM116547 - Homo sapiens HNF1 alpha A splice variant 7 (HNF1A) mRNA, complete cds, alternatively spliced. HM116548 - Homo sapiens HNF1 alpha A splice variant 8 (HNF1A) mRNA, complete cds, alternatively spliced. HM116549 - Homo sapiens HNF1 alpha A splice variant 8 (HNF1A) mRNA, partial sequence. HM116550 - Homo sapiens HNF1 alpha A splice variant 10 (HNF1A) mRNA, partial sequence. HM116551 - Homo sapiens HNF1 alpha A splice variant 11 (HNF1A) mRNA, partial sequence. X71347 - H.sapiens HNF1-C mRNA. HM116552 - Homo sapiens HNF1 alpha C splice variant 1 (HNF1A) mRNA, complete cds, alternatively spliced. HM116557 - Homo sapiens HNF1 alpha B splice variant 1 (HNF1A) mRNA, complete cds, alternatively spliced. HM116558 - Homo sapiens HNF1 alpha B splice variant 2 (HNF1A) mRNA, complete cds, alternatively spliced. HM116559 - Homo sapiens HNF1 alpha B splice variant 3 (HNF1A) mRNA, complete cds, alternatively spliced. HM116560 - Homo sapiens HNF1 alpha B splice variant 4 (HNF1A) mRNA, complete sequence. HM116561 - Homo sapiens HNF1 alpha B splice variant 6 (HNF1A) mRNA, complete cds, alternatively spliced. HM116562 - Homo sapiens HNF1 alpha B splice variant 7 (HNF1A) mRNA, partial sequence. HM116563 - Homo sapiens HNF1 alpha B splice variant 5 (HNF1A) mRNA, complete cds, alternatively spliced. AK298422 - Homo sapiens cDNA FLJ56500 complete cds, highly similar to Hepatocyte nuclear factor 1-alpha. M57732 - Human hepatic nuclear factor 1 (TCF1) mRNA, complete cds, clones HCL10, HCL12, HCL17, and HCL20. HM449088 - Homo sapiens HNF1A homeobox A insIVS8 (HNF1A) mRNA, complete cds. HM449089 - Homo sapiens HNF1A homeobox A delta 2 (HNF1A) mRNA, complete cds. BC143483 - Homo sapiens cDNA clone IMAGE:9051991. BC104908 - Homo sapiens HNF1 homeobox A, mRNA (cDNA clone MGC:132568 IMAGE:8143911), complete cds. BC104910 - Homo sapiens HNF1 homeobox A, mRNA (cDNA clone MGC:132570 IMAGE:8143913), complete cds. AB527468 - Synthetic construct DNA, clone: pF1KB7864, Homo sapiens HNF1A gene for HNF1 homeobox A, without stop codon, in Flexi system. EU446660 - Synthetic construct Homo sapiens clone IMAGE:100069800; IMAGE:100011869; FLH258602.01L transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor (TCF1) gene, encodes complete protein. JD384877 - Sequence 365901 from Patent EP1572962. JD393439 - Sequence 374463 from Patent EP1572962. JD399269 - Sequence 380293 from Patent EP1572962. JD140437 - Sequence 121461 from Patent EP1572962. JD325786 - Sequence 306810 from Patent EP1572962. JD232221 - Sequence 213245 from Patent EP1572962. JD084612 - Sequence 65636 from Patent EP1572962. JD151403 - Sequence 132427 from Patent EP1572962. JD402503 - Sequence 383527 from Patent EP1572962. JD151356 - Sequence 132380 from Patent EP1572962. JD439384 - Sequence 420408 from Patent EP1572962. JD114199 - Sequence 95223 from Patent EP1572962. JD222848 - Sequence 203872 from Patent EP1572962. JD457587 - Sequence 438611 from Patent EP1572962. JD389061 - Sequence 370085 from Patent EP1572962. JD385944 - Sequence 366968 from Patent EP1572962. JD132346 - Sequence 113370 from Patent EP1572962. JD518312 - Sequence 499336 from Patent EP1572962. JD333869 - Sequence 314893 from Patent EP1572962. JD260389 - Sequence 241413 from Patent EP1572962. JD159464 - Sequence 140488 from Patent EP1572962. JD326653 - Sequence 307677 from Patent EP1572962. JD483326 - Sequence 464350 from Patent EP1572962. JD102688 - Sequence 83712 from Patent EP1572962. JD480169 - Sequence 461193 from Patent EP1572962. JD140218 - Sequence 121242 from Patent EP1572962. JD287974 - Sequence 268998 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_ghPathway - Growth Hormone Signaling Pathway h_wntPathway - WNT Signaling Pathway h_ps1Pathway - Presenilin action in Notch and Wnt signaling h_hesPathway - Segmentation Clock h_malPathway - Role of MAL in Rho-Mediated Activation of SRF h_alkPathway - ALK in cardiac myocytes
GeneReviews article(s) related to gene HNF1A: hi (Nonsyndromic Genetic Hyperinsulinism Overview) mody-ov (Maturity-Onset Diabetes of the Young Overview)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 