Human Gene HNRNPA0 (ENST00000314940.7_6) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: heterogeneous nuclear ribonucleoprotein A0 (from RefSeq NM_006805.4)
Gencode Transcript: ENST00000314940.7_6
Gencode Gene: ENSG00000177733.8_10
Transcript (Including UTRs)
Position: hg19 chr5:137,081,340-137,090,052 Size: 8,713 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr5:137,088,838-137,089,755 Size: 918 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:137,081,340-137,090,052)			mRNA (may differ from genome)		Protein (305 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	Reactome	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ROA0_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein A0; Short=hnRNP A0; FUNCTION: mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs. SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Component of ribonucleosomes (By similarity). PTM: Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA. PTM: Arg-291 is dimethylated, probably to asymmetric dimethylarginine. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D001564 Benzo(a)pyrene D003993 Dibutyl Phthalate D014635 Valproic Acid C006780 bisphenol A C012301 domoic acid C012589 trichostatin A

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 73.60 RPKM in Ovary Total median expression: 2059.09 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-128.60	297	-0.433	Picture	PostScript	Text
3' UTR	-1998.60	7498	-0.267	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

SCOP Domains:
50249 - Nucleic acid-binding proteins
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on Q13151


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0017091 AU-rich element binding GO:0019901 protein kinase binding Biological Process: GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0006954 inflammatory response GO:0016070 RNA metabolic process GO:0032496 response to lipopolysaccharide GO:0070935 3'-UTR-mediated mRNA stabilization Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm

Descriptions from all associated GenBank mRNAs


	JD026605 - Sequence 7629 from Patent EP1572962. JD026988 - Sequence 8012 from Patent EP1572962. JD034570 - Sequence 15594 from Patent EP1572962. JD028666 - Sequence 9690 from Patent EP1572962. BC018949 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:16754 IMAGE:4131137), complete cds. BC012490 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone IMAGE:3447569), with apparent retained intron. BC007271 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:15589 IMAGE:3160840), complete cds. U23803 - Human heterogeneous ribonucleoprotein A0 mRNA, complete cds. BC019271 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:3519 IMAGE:2823669), complete cds. BC001008 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:8694 IMAGE:2964662), complete cds. BC018800 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone IMAGE:3605889). BC012980 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:16084 IMAGE:3617551), complete cds. BC028976 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:30185 IMAGE:4993025), complete cds. BC030249 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:40050 IMAGE:5242912), complete cds. BC011972 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:17503 IMAGE:3454140), complete cds. JD199834 - Sequence 180858 from Patent EP1572962. AK311328 - Homo sapiens cDNA, FLJ18370. L10372 - Human (clone CCG-A3) mRNA sequence. JD309096 - Sequence 290120 from Patent EP1572962. JD132927 - Sequence 113951 from Patent EP1572962. JD193831 - Sequence 174855 from Patent EP1572962. JD555600 - Sequence 536624 from Patent EP1572962. JD233591 - Sequence 214615 from Patent EP1572962. BC009284 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0, mRNA (cDNA clone MGC:14361 IMAGE:4299262), complete cds. CR456986 - Homo sapiens full open reading frame cDNA clone RZPDo834D055D for gene HNRPA0, heterogeneous nuclear ribonucleoprotein A0; complete cds, incl. stopcodon. KJ905406 - Synthetic construct Homo sapiens clone ccsbBroadEn_14980 HNRNPA0 gene, encodes complete protein. AB528924 - Synthetic construct DNA, clone: pF1KE0717, Homo sapiens HNRPA0 gene for heterogeneous nuclear ribonucleoprotein A0, without stop codon, in Flexi system. JD195542 - Sequence 176566 from Patent EP1572962. JD395698 - Sequence 376722 from Patent EP1572962. JD443997 - Sequence 425021 from Patent EP1572962. JD521513 - Sequence 502537 from Patent EP1572962. JD402373 - Sequence 383397 from Patent EP1572962. JD394016 - Sequence 375040 from Patent EP1572962. JD253730 - Sequence 234754 from Patent EP1572962. JD464395 - Sequence 445419 from Patent EP1572962. JD470799 - Sequence 451823 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q13151 (Reactome details) participates in the following event(s): R-HSA-72103 Formation of pre-mRNPs R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing

Other Names for This Gene


	Alternate Gene Symbols: ENST00000314940.1, ENST00000314940.2, ENST00000314940.3, ENST00000314940.4, ENST00000314940.5, ENST00000314940.6, HNRPA0, NM_006805, Q13151, Q6IB18, ROA0_HUMAN, uc317psr.1, uc317psr.2 UCSC ID: ENST00000314940.7_6 RefSeq Accession: NM_006805.4 Protein: Q13151 (aka ROA0_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.