Human Gene HNRNPAB (ENST00000358344.8_8) from GENCODE V47lift37
  Description: heterogeneous nuclear ribonucleoprotein A/B, transcript variant 1 (from RefSeq NM_031266.3)
Gencode Transcript: ENST00000358344.8_8
Gencode Gene: ENSG00000197451.12_12
Transcript (Including UTRs)
   Position: hg19 chr5:177,631,534-177,638,164 Size: 6,631 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr5:177,631,839-177,637,624 Size: 5,786 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:177,631,534-177,638,164)mRNA (may differ from genome)Protein (332 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ROAA_HUMAN
DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein A/B; Short=hnRNP A/B; AltName: Full=APOBEC1-binding protein 1; Short=ABBP-1;
FUNCTION: Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
SUBUNIT: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with APOBEC1.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
TISSUE SPECIFICITY: Ubiquitous.
PTM: Dimethylation at Arg-322 is probably asymmetric.
SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
SEQUENCE CAUTION: Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HNRNPAB
Diseases sorted by gene-association score: hay-wells syndrome (3), wells syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 106.48 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2231.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.70231-0.523 Picture PostScript Text
3' UTR -147.70540-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012956 - CARG-binding_factor_N
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF08143 - CBFNT (NUC161) domain
PF16367 - RNA recognition motif

SCOP Domains:
54928 - RNA-binding domain, RBD

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3S7R - X-ray


ModBase Predicted Comparative 3D Structure on Q99729
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0001837 epithelial to mesenchymal transition
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0090575 RNA polymerase II transcription factor complex
GO:1990904 ribonucleoprotein complex


-  Descriptions from all associated GenBank mRNAs
  AK097657 - Homo sapiens cDNA FLJ40338 fis, clone TESTI2032067, highly similar to Rattus norvegicus mRNA for type A/B hnRNP protein p40.
AK054600 - Homo sapiens cDNA FLJ30038 fis, clone 3NB692001511, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein A/B (HNRPAB), transcript variant 2, mRNA.
AK223425 - Homo sapiens mRNA for heterogeneous nuclear ribonucleoprotein AB isoform a variant, clone: FCC110E04.
BC004561 - Homo sapiens heterogeneous nuclear ribonucleoprotein A/B, mRNA (cDNA clone MGC:10739 IMAGE:3960088), complete cds.
BC009359 - Homo sapiens heterogeneous nuclear ribonucleoprotein A/B, mRNA (cDNA clone MGC:15339 IMAGE:4301401), complete cds.
BC001616 - Homo sapiens heterogeneous nuclear ribonucleoprotein A/B, mRNA (cDNA clone MGC:2092 IMAGE:3547193), complete cds.
BC002625 - Homo sapiens heterogeneous nuclear ribonucleoprotein A/B, mRNA (cDNA clone MGC:4273 IMAGE:3606731), complete cds.
BC015556 - Homo sapiens cDNA clone IMAGE:3346139, containing frame-shift errors.
BC036708 - Homo sapiens heterogeneous nuclear ribonucleoprotein A/B, mRNA (cDNA clone MGC:20812 IMAGE:4331453), complete cds.
JD340076 - Sequence 321100 from Patent EP1572962.
M65028 - Human hnRNP type A/B protein mRNA, complete cds.
U76713 - Human apobec-1 binding protein 1 mRNA, complete cds.
AB463727 - Synthetic construct DNA, clone: pF1KB6495, Homo sapiens HNRPAB gene for heterogeneous nuclear ribonucleoprotein A/B, without stop codon, in Flexi system.
AK297686 - Homo sapiens cDNA FLJ60713 complete cds, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein A/B (HNRPAB), transcript variant 1, mRNA.
Z36844 - H.sapiens (xs87) mRNA, 368bp.
JD042195 - Sequence 23219 from Patent EP1572962.
JD461406 - Sequence 442430 from Patent EP1572962.
JD424433 - Sequence 405457 from Patent EP1572962.
JD273562 - Sequence 254586 from Patent EP1572962.
JD200965 - Sequence 181989 from Patent EP1572962.
JD255335 - Sequence 236359 from Patent EP1572962.
JD290849 - Sequence 271873 from Patent EP1572962.
JD301003 - Sequence 282027 from Patent EP1572962.
JD155411 - Sequence 136435 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ABBP1, B3KNN5, D3DWP7, ENST00000358344.1, ENST00000358344.2, ENST00000358344.3, ENST00000358344.4, ENST00000358344.5, ENST00000358344.6, ENST00000358344.7, HNRPAB, NM_031266, Q04150, Q8N7U3, Q99729, Q9BQ99, ROAA_HUMAN, uc318amp.1, uc318amp.2
UCSC ID: ENST00000358344.8_8
RefSeq Accession: NM_031266.3
Protein: Q99729 (aka ROAA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.