ID:HOOK2_HUMAN DESCRIPTION: RecName: Full=Protein Hook homolog 2; Short=h-hook2; Short=hHK2; FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. SUBUNIT: Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with CEP110. Interacts with microtubules. Interacts with ZC3H14. INTERACTION: Q8N5R6:CCDC33; NbExp=2; IntAct=EBI-743290, EBI-740841; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. SIMILARITY: Belongs to the hook family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96ED9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008017 microtubule binding GO:0042802 identical protein binding GO:0051959 dynein light intermediate chain binding
Biological Process: GO:0006897 endocytosis GO:0007032 endosome organization GO:0007040 lysosome organization GO:0008333 endosome to lysosome transport GO:0015031 protein transport GO:0030705 cytoskeleton-dependent intracellular transport GO:0031122 cytoplasmic microtubule organization GO:0045022 early endosome to late endosome transport
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
