ID:HOOK3_HUMAN DESCRIPTION: RecName: Full=Protein Hook homolog 3; Short=h-hook3; Short=hHK3; FUNCTION: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. SUBUNIT: Interacts with Salmonella typhimurium spiC (By similarity). Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK2. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with MSR1, and this association is stimulated by ligand binding to MSR1. Interacts with microtubules. INTERACTION: P21757:MSR1; NbExp=4; IntAct=EBI-1777078, EBI-1776976; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex (By similarity). Localizes to microtubule asters in prophase (By similarity). SIMILARITY: Belongs to the hook family. SEQUENCE CAUTION: Sequence=AAH48304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86VS8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007032 endosome organization GO:0007040 lysosome organization GO:0008333 endosome to lysosome transport GO:0015031 protein transport GO:0022027 interkinetic nuclear migration GO:0030705 cytoskeleton-dependent intracellular transport GO:0031122 cytoplasmic microtubule organization GO:0034454 microtubule anchoring at centrosome GO:0045022 early endosome to late endosome transport GO:0050768 negative regulation of neurogenesis GO:0051645 Golgi localization GO:0071539 protein localization to centrosome GO:0097150 neuronal stem cell population maintenance
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
