ID:HXA10_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-A10; AltName: Full=Homeobox protein Hox-1.8; AltName: Full=Homeobox protein Hox-1H; AltName: Full=PL; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. INTERACTION: P17947:SPI1; NbExp=2; IntAct=EBI-2293516, EBI-2293548; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Abd-B homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. SEQUENCE CAUTION: Sequence=AAB96917.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH13971.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB86198.1; Type=Frameshift; Positions=Several;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31260
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0005515 protein binding GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001501 skeletal system development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007283 spermatogenesis GO:0007338 single fertilization GO:0008584 male gonad development GO:0009952 anterior/posterior pattern specification GO:0009954 proximal/distal pattern formation GO:0010468 regulation of gene expression GO:0030326 embryonic limb morphogenesis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060065 uterus development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
