ID:HXA5_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-A5; AltName: Full=Homeobox protein Hox-1C; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed during embryogenesis and in adult kidney. SIMILARITY: Belongs to the Antp homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20719
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001501 skeletal system development GO:0002009 morphogenesis of an epithelium GO:0003016 respiratory system process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0007585 respiratory gaseous exchange GO:0009952 anterior/posterior pattern specification GO:0010870 positive regulation of receptor biosynthetic process GO:0016477 cell migration GO:0016525 negative regulation of angiogenesis GO:0030324 lung development GO:0030878 thyroid gland development GO:0033599 regulation of mammary gland epithelial cell proliferation GO:0035264 multicellular organism growth GO:0043065 positive regulation of apoptotic process GO:0045639 positive regulation of myeloid cell differentiation GO:0045647 negative regulation of erythrocyte differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048286 lung alveolus development GO:0048704 embryonic skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0060435 bronchiole development GO:0060439 trachea morphogenesis GO:0060441 epithelial tube branching involved in lung morphogenesis GO:0060480 lung goblet cell differentiation GO:0060481 lobar bronchus epithelium development GO:0060484 lung-associated mesenchyme development GO:0060535 trachea cartilage morphogenesis GO:0060536 cartilage morphogenesis GO:0060574 intestinal epithelial cell maturation GO:0060638 mesenchymal-epithelial cell signaling GO:0060644 mammary gland epithelial cell differentiation GO:0060749 mammary gland alveolus development GO:0060764 cell-cell signaling involved in mammary gland development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
