ID:HXB9_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-B9; AltName: Full=Homeobox protein Hox-2.5; AltName: Full=Homeobox protein Hox-2E; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. INTERACTION: Q99750:MDFI; NbExp=3; IntAct=EBI-745290, EBI-724076; P21673:SAT1; NbExp=3; IntAct=EBI-745290, EBI-711613; SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9 weeks from conception. SIMILARITY: Belongs to the Abd-B homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00046 - Homeodomain PF04617 - Hox9 activation region
SCOP Domains: 46689 - Homeodomain-like 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
ModBase Predicted Comparative 3D Structure on P17482
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0009952 anterior/posterior pattern specification GO:0030879 mammary gland development GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048706 embryonic skeletal system development GO:0060070 canonical Wnt signaling pathway GO:0060326 cell chemotaxis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
