Human Gene HPR (ENST00000540303.7_4) from GENCODE V47lift37
  Description: haptoglobin-related protein, transcript variant 1 (from RefSeq NM_020995.4)
Gencode Transcript: ENST00000540303.7_4
Gencode Gene: ENSG00000261701.9_9
Transcript (Including UTRs)
   Position: hg19 chr16:72,097,125-72,111,145 Size: 14,021 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr16:72,097,155-72,110,980 Size: 13,826 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:72,097,125-72,111,145)mRNA (may differ from genome)Protein (348 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HPTR_HUMAN
DESCRIPTION: RecName: Full=Haptoglobin-related protein; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 1 peptidase S1 domain.
SIMILARITY: Contains 1 Sushi (CCP/SCR) domain.
CAUTION: Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HPR
Diseases sorted by gene-association score: anhaptoglobinemia (5), trypanosomiasis (3), breast cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 175.03 RPKM in Liver
Total median expression: 272.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.3030-0.110 Picture PostScript Text
3' UTR -42.50165-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016060 - Complement_control_module
IPR008292 - Haptoglobin
IPR009003 - Pept_cys/ser_Trypsin-like
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00089 - Trypsin

SCOP Domains:
50494 - Trypsin-like serine proteases
57535 - Complement control module/SCR domain

ModBase Predicted Comparative 3D Structure on P00739
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030492 hemoglobin binding

Biological Process:
GO:0006898 receptor-mediated endocytosis

Cellular Component:
GO:0005576 extracellular region
GO:0034366 spherical high-density lipoprotein particle
GO:0070062 extracellular exosome
GO:0072562 blood microparticle


-  Descriptions from all associated GenBank mRNAs
  X89214 - H.sapiens mRNA for haptoglobin related protein.
BC160066 - Synthetic construct Homo sapiens clone IMAGE:100064002, MGC:193181 haptoglobin-related protein (HPR) mRNA, encodes complete protein.
JD199811 - Sequence 180835 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P00739 (Reactome details) participates in the following event(s):

R-HSA-2168889 Haptoglobin-related Protein binds Hemoglobin
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000540303.1, ENST00000540303.2, ENST00000540303.3, ENST00000540303.4, ENST00000540303.5, ENST00000540303.6, HPTR_HUMAN, NM_020995, P00739, Q7LE20, Q92658, Q92659, Q9ULB0, uc324sbb.1, uc324sbb.2
UCSC ID: ENST00000540303.7_4
RefSeq Accession: NM_020995.4
Protein: P00739 (aka HPTR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.