ID:HEMO_HUMAN DESCRIPTION: RecName: Full=Hemopexin; AltName: Full=Beta-1B-glycoprotein; Flags: Precursor; FUNCTION: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. SUBUNIT: Interacts with HEV ORF3 protein. Interacts with FLVCR1. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. PTM: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. MISCELLANEOUS: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity). SIMILARITY: Belongs to the hemopexin family. SIMILARITY: Contains 5 hemopexin-like domains. SEQUENCE CAUTION: Sequence=CAA26382.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02790
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002639 positive regulation of immunoglobulin production GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0006879 cellular iron ion homeostasis GO:0006898 receptor-mediated endocytosis GO:0015886 heme transport GO:0016032 viral process GO:0020027 hemoglobin metabolic process GO:0042168 heme metabolic process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0051246 regulation of protein metabolic process GO:0060332 positive regulation of response to interferon-gamma GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
X02537 - Human mRNA for serum beta-glycoprotein hemopexin. J03048 - Huma hemopexin mRNA, 3' end. BC005395 - Homo sapiens hemopexin, mRNA (cDNA clone MGC:12533 IMAGE:4071616), complete cds. GQ891443 - Homo sapiens clone HEL-S-164 epididymis secretory sperm binding protein mRNA, complete cds. AK313648 - Homo sapiens cDNA, FLJ94225, highly similar to Homo sapiens hemopexin (HPX), mRNA. JF432450 - Synthetic construct Homo sapiens clone IMAGE:100073661 hemopexin (HPX) gene, encodes complete protein. KJ901496 - Synthetic construct Homo sapiens clone ccsbBroadEn_10890 HPX gene, encodes complete protein. AK303758 - Homo sapiens cDNA FLJ56652 complete cds, highly similar to Hemopexin precursor.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P02790 (Reactome details) participates in the following event(s):
R-HSA-2168884 Ferriheme is transferred from Methemoglobin to Hemopexin R-HSA-2168886 Hemopexin binds Heme b R-HSA-2168887 Ferriheme is transferred from Albumin to Hemopexin R-HSA-2168897 LRP1 (CD91) binds Hemopexin:heme R-HSA-2168880 Scavenging of heme from plasma R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
