Human Gene HRAS (ENST00000417302.7_8) from GENCODE V47lift37
  Description: HRas proto-oncogene, GTPase, transcript variant 2 (from RefSeq NM_176795.5)
Gencode Transcript: ENST00000417302.7_8
Gencode Gene: ENSG00000174775.18_12
Transcript (Including UTRs)
   Position: hg19 chr11:532,242-535,576 Size: 3,335 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr11:533,296-534,322 Size: 1,027 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:532,242-535,576)mRNA (may differ from genome)Protein (170 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RASH_HUMAN
DESCRIPTION: RecName: Full=GTPase HRas; AltName: Full=H-Ras-1; AltName: Full=Ha-Ras; AltName: Full=Transforming protein p21; AltName: Full=c-H-ras; AltName: Full=p21ras; Contains: RecName: Full=GTPase HRas, N-terminally processed; Flags: Precursor;
FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
ENZYME REGULATION: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP).
SUBUNIT: In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3. Interacts with HSPD1. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ. Interacts with RASSF5. Interacts with PDE6D. Interacts with IKZF3. Interacts with GNB2L1. Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer- dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity).
INTERACTION: Q7Z569:BRAP; NbExp=3; IntAct=EBI-350145, EBI-349900; P42337:Pik3ca (xeno); NbExp=2; IntAct=EBI-350145, EBI-641748; Q9Z0S9:Rabac1 (xeno); NbExp=4; IntAct=EBI-350145, EBI-476965; P04049:RAF1; NbExp=8; IntAct=EBI-350145, EBI-365996; Q9EQZ6:Rapgef4 (xeno); NbExp=3; IntAct=EBI-350145, EBI-772212; Q9NS23-2:RASSF1; NbExp=2; IntAct=EBI-350145, EBI-438698; Q5EBH1-2:Rassf5 (xeno); NbExp=3; IntAct=EBI-350145, EBI-960547; Q13671:RIN1; NbExp=5; IntAct=EBI-350145, EBI-366017; Q07889:SOS1; NbExp=6; IntAct=EBI-350145, EBI-297487;
SUBCELLULAR LOCATION: Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus.
SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with GNB2L1 to the perinuclear region.
TISSUE SPECIFICITY: Widely expressed.
PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
PTM: S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation.
PTM: The covalent modification of cysteine by 15-deoxy-Delta12,14- prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S- nitrosylation and S-palmitoylation.
MASS SPECTROMETRY: Mass=6223; Mass_error=2; Method=Electrospray; Range=112-166; Source=PubMed:9020151;
MASS SPECTROMETRY: Mass=6253; Mass_error=2; Method=Electrospray; Range=112-166; Note=Includes one nitric oxide molecule; Source=PubMed:9020151;
DISEASE: Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS) [MIM:218040]. A rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities.
DISEASE: Defects in HRAS are the cause of congenital myopathy with excess of muscle spindles (CMEMS) [MIM:218040]. CMEMS is a variant of Costello syndrome.
DISEASE: Defects in HRAS may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
DISEASE: Note=Mutations which change positions 12, 13 or 61 activate the potential of HRAS to transform cultured cells and are implicated in a variety of human tumors.
DISEASE: Defects in HRAS are a cause of susceptibility to bladder cancer (BLC) [MIM:109800]. A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas. They begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences.
DISEASE: Note=Defects in HRAS are the cause of oral squamous cell carcinoma (OSCC).
DISEASE: Defects in HRAS are the cause of Schimmelpenning- Feuerstein-Mims syndrome (SFM) [MIM:163200]. A disease characterized by sebaceous nevi, often on the face, associated with variable ipsilateral abnormalities of the central nervous system, ocular anomalies, and skeletal defects. Many oral manifestations have been reported, not only including hypoplastic and malformed teeth, and mucosal papillomatosis, but also ankyloglossia, hemihyperplastic tongue, intraoral nevus, giant cell granuloma, ameloblastoma, bone cysts, follicular cysts, oligodontia, and odontodysplasia. Sebaceous nevi follow the lines of Blaschko and these can continue as linear intraoral lesions, as in mucosal papillomatosis.
SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HRASID108.html";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HRAS";

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HRAS
Diseases sorted by gene-association score: costello syndrome* (1710), schimmelpenning-feuerstein-mims syndrome, somatic mosaic* (1250), epidermal nevus, somatic* (520), thyroid cancer, nonmedullary, 2* (494), melanocytic nevus syndrome, congenital, somatic* (389), phakomatosis pigmentokeratotica* (350), bladder cancer, somatic* (332), colorectal cancer* (82), differentiated thyroid carcinoma* (76), thyroid cancer (40), oral squamous cell carcinoma (34), sarcoma (33), phacomatosis pigmentokeratotica (18), squamous cell carcinoma (18), spitz nevus (16), pancreatic ductal adenocarcinoma (15), cardiofaciocutaneous syndrome (15), chromosome 1q21.1 deletion syndrome (14), ampulla of vater neoplasm (13), thymic neuroendocrine tumor (12), lung cancer (12), duodenum cancer (11), epithelial-myoepithelial carcinoma (11), ankyloglossia (11), ectomesenchymoma (10), sigmoid neoplasm (10), cell type cancer (10), congenital myopathy (9), urbach-wiethe disease (9), colorectal adenoma (9), acneiform dermatitis (9), deafness, autosomal dominant 49 (9), neurofibromatosis, type 1 (9), lung cancer susceptibility 3 (8), diabetes mellitus, insulin-dependent, 15 (8), chromosome 1q21.1 duplication syndrome (8), intestinal benign neoplasm (8), malignant ectomesenchymoma (8), colorectal adenocarcinoma (8), gastrointestinal system cancer (8), deafness, autosomal dominant 7 (8), pancreas adenocarcinoma (7), noonan syndrome 1 (7), gastrointestinal system benign neoplasm (7), leopard syndrome (7), dermatitis, atopic 2 (7), meningeal melanomatosis (7), pycnodysostosis (7), paronychia (7), episodic kinesigenic dyskinesia 2 (7), multinodular goiter (7), ovary serous adenocarcinoma (7), dyschromatosis symmetrica hereditaria (7), penile cancer (6), thrombocytopenia-absent radius syndrome (6), sporadic pheochromocytoma (6), pulmonic stenosis (6), myelodysplastic myeloproliferative cancer (6), juvenile glaucoma (6), chromosome 14q11-q22 deletion syndrome (6), adenocarcinoma (6), ovarian cystadenocarcinoma (6), periampullary adenoma (6), benign struma ovarii (6), embryonal rhabdomyosarcoma (6), biliary tract neoplasm (6), exanthem (6), adenosquamous pancreas carcinoma (6), autoimmune lymphoproliferative syndrome (6), cell type benign neoplasm (6), rectal neoplasm (6), ovary adenocarcinoma (6), lung benign neoplasm (6), core binding factor acute myeloid leukemia (5), chromosome 13q14 deletion syndrome (5), melanomatosis (5), melanoma (5), ovarian melanoma (5), aggressive digital papillary adenocarcinoma (5), bile duct adenocarcinoma (5), integumentary system cancer (5), chromosome 4q21 deletion syndrome (5), thyroid cancer, nonmedullary, 1 (5), malignant skin fibrous histiocytoma (5), malignant dermis tumor (5), adenosquamous cell lung carcinoma (5), malignant fibrous histiocytoma of bone (5), vulvar melanoma (5), clivus chordoma (5), ethmoid sinus cancer (5), ethmoid sinus adenocarcinoma (5), biliary papillomatosis (5), pilocytic astrocytoma (5), skin benign neoplasm (5), colloid carcinoma of the pancreas (5), endocrine gland cancer (5), central nervous system melanocytic neoplasm (5), malignant struma ovarii (5), nasal cavity adenocarcinoma (5), marcus gunn phenomenon (5), endometrial cancer (5), adult fibrosarcoma (4), chromosome 22q11.2 microduplication syndrome (4), secondary hypertrophic osteoarthropathy (4), lung adenoid cystic carcinoma (4), tonsil squamous cell carcinoma (4), mixed cell type cancer (4), lacrimal gland adenocarcinoma (4), pancreatic mucinous cystadenoma (4), hereditary wilms' tumor (4), transverse colon cancer (4), hereditary motor and sensory neuropathy, type iic (4), pancreatic cancer (4), liver angiosarcoma (4), botryoid rhabdomyosarcoma (4), myopathy (3), cardiomyopathy (3), urinary bladder cancer (3), breast cancer (2), prostate cancer (2), stomach cancer (2), myelofibrosis with myeloid metaplasia, somatic (2), hematologic cancer (2), leukemia, chronic myeloid, somatic (1), charcot-marie-tooth disease, type 2e (1), diabetes mellitus, insulin-dependent (1), ovary epithelial cancer (1), female reproductive organ cancer (1), malignant ovarian surface epithelial-stromal neoplasm (1), malignant melanoma, somatic (1), leukemia, acute myeloid (1), colonic benign neoplasm (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.23 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 1095.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -106.50214-0.498 Picture PostScript Text
3' UTR -218.20533-0.409 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR020849 - Small_GTPase_Ras

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
121P - X-ray MuPIT 1AA9 - NMR MuPIT 1AGP - X-ray MuPIT 1BKD - X-ray MuPIT 1CLU - X-ray MuPIT 1CRP - NMR MuPIT 1CRQ - NMR MuPIT 1CRR - NMR 1CTQ - X-ray MuPIT 1GNP - X-ray MuPIT 1GNQ - X-ray MuPIT 1GNR - X-ray MuPIT 1HE8 - X-ray MuPIT 1IAQ - X-ray MuPIT 1IOZ - X-ray MuPIT 1JAH - X-ray MuPIT 1JAI - X-ray MuPIT 1K8R - X-ray MuPIT 1LF0 - X-ray MuPIT 1LF5 - X-ray MuPIT 1LFD - X-ray 1NVU - X-ray MuPIT 1NVV - X-ray MuPIT 1NVW - X-ray MuPIT 1NVX - X-ray MuPIT 1P2S - X-ray MuPIT 1P2T - X-ray MuPIT 1P2U - X-ray MuPIT 1P2V - X-ray MuPIT 1PLJ - X-ray MuPIT 1PLK - X-ray MuPIT 1PLL - X-ray MuPIT 1Q21 - X-ray MuPIT 1QRA - X-ray MuPIT 1RVD - X-ray MuPIT 1WQ1 - X-ray MuPIT 1XCM - X-ray MuPIT 1XD2 - X-ray MuPIT 1XJ0 - X-ray MuPIT 1ZVQ - X-ray MuPIT 1ZW6 - X-ray MuPIT 221P - X-ray MuPIT 2C5L - X-ray MuPIT 2CE2 - X-ray MuPIT 2CL0 - X-ray MuPIT 2CL6 - X-ray MuPIT 2CL7 - X-ray MuPIT 2CLC - X-ray MuPIT 2CLD - X-ray MuPIT 2EVW - X-ray MuPIT 2GDP - Model 2LCF - NMR MuPIT 2Q21 - X-ray MuPIT 2QUZ - X-ray MuPIT 2RGA - X-ray MuPIT 2RGB - X-ray MuPIT 2RGC - X-ray MuPIT 2RGD - X-ray MuPIT 2RGE - X-ray MuPIT 2RGG - X-ray MuPIT 2UZI - X-ray MuPIT 2VH5 - X-ray MuPIT 2X1V - X-ray MuPIT 3DDC - X-ray MuPIT 3I3S - X-ray MuPIT 3K8Y - X-ray MuPIT 3K9L - X-ray MuPIT 3K9N - X-ray MuPIT 3KKM - X-ray MuPIT 3KKN - X-ray MuPIT 3KUD - X-ray MuPIT 3L8Y - X-ray MuPIT 3L8Z - X-ray MuPIT 3LBH - X-ray MuPIT 3LBI - X-ray MuPIT 3LBN - X-ray MuPIT 3LO5 - X-ray MuPIT 3OIU - X-ray MuPIT 3OIV - X-ray MuPIT 3OIW - X-ray MuPIT 3RRY - X-ray MuPIT 3RRZ - X-ray MuPIT 3RS0 - X-ray MuPIT 3RS2 - X-ray MuPIT 3RS3 - X-ray MuPIT 3RS4 - X-ray MuPIT 3RS5 - X-ray MuPIT 3RS7 - X-ray MuPIT 3RSL - X-ray MuPIT 3RSO - X-ray MuPIT 3TGP - X-ray MuPIT 421P - X-ray MuPIT 4DLR - X-ray MuPIT 4DLS - X-ray MuPIT 4DLT - X-ray MuPIT 4DLU - X-ray MuPIT 4DLV - X-ray MuPIT 4DLW - X-ray MuPIT 4DLX - X-ray MuPIT 4DLY - X-ray MuPIT 4DLZ - X-ray MuPIT 4DST - X-ray MuPIT 4DSU - X-ray MuPIT 4EFL - X-ray MuPIT 4EFM - X-ray MuPIT 4EFN - X-ray MuPIT 4Q21 - X-ray MuPIT 521P - X-ray MuPIT 5P21 - X-ray MuPIT 621P - X-ray MuPIT 6Q21 - X-ray MuPIT 721P - X-ray MuPIT 821P - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P01112
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
GO:0019003 GDP binding

Biological Process:
GO:0000165 MAPK cascade
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010863 positive regulation of phospholipase C activity
GO:0030335 positive regulation of cell migration
GO:0032729 positive regulation of interferon-gamma production
GO:0034260 negative regulation of GTPase activity
GO:0035900 response to isolation stress
GO:0042088 T-helper 1 type immune response
GO:0042832 defense response to protozoan
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0051291 protein heterooligomerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071480 cellular response to gamma radiation
GO:0090303 positive regulation of wound healing
GO:0090314 positive regulation of protein targeting to membrane
GO:0090398 cellular senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900029 positive regulation of ruffle assembly
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000630 positive regulation of miRNA metabolic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC006499 - Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:2359 IMAGE:2819996), complete cds.
FW413071 - NUCLEIC ACID COMPOUNDS FOR INHIBITING RAS GENE EXPRESSION AND USES THEREOF.
FW413072 - NUCLEIC ACID COMPOUNDS FOR INHIBITING RAS GENE EXPRESSION AND USES THEREOF.
JA661268 - Sequence 1 from Patent WO2011133584.
CS544947 - Sequence 56 from Patent WO2006028967.
DL262781 - Regulation of Oncogenes by MicroRNAs.
HW270260 - JP 2012105669-A/56: Regulation of Oncogenes by MicroRNAs.
JA072126 - Sequence 56 from Patent EP2298897.
JC192451 - Sequence 56 from Patent EP2338993.
JC246371 - Sequence 56 from Patent EP2338994.
CS544946 - Sequence 55 from Patent WO2006028967.
DL262780 - Regulation of Oncogenes by MicroRNAs.
HW270259 - JP 2012105669-A/55: Regulation of Oncogenes by MicroRNAs.
JA072125 - Sequence 55 from Patent EP2298897.
JC192450 - Sequence 55 from Patent EP2338993.
JC246370 - Sequence 55 from Patent EP2338994.
CS544945 - Sequence 54 from Patent WO2006028967.
DL262779 - Regulation of Oncogenes by MicroRNAs.
HW270258 - JP 2012105669-A/54: Regulation of Oncogenes by MicroRNAs.
JA072124 - Sequence 54 from Patent EP2298897.
JC192449 - Sequence 54 from Patent EP2338993.
JC246369 - Sequence 54 from Patent EP2338994.
AF493916 - Homo sapiens Ras family small GTP binding protein H-Ras (HRAS) mRNA, complete cds.
BC095471 - Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:111377 IMAGE:6519193), complete cds.
CR536579 - Homo sapiens full open reading frame cDNA clone RZPDo834G0522D for gene HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; complete cds, incl. stopcodon.
AB451336 - Homo sapiens HRAS mRNA for v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1, complete cds, clone: FLJ82516SAAN.
BT019421 - Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog mRNA, complete cds.
AB451485 - Homo sapiens HRAS mRNA for v-Ha-ras Harvey rat sarcoma viral oncogene homolog isoform 1, partial cds, clone: FLJ82516SAAF.
AB527708 - Synthetic construct DNA, clone: pF1KB6834, Homo sapiens HRAS gene for v-Ha-ras Harvey rat sarcoma viral oncogene homolog, without stop codon, in Flexi system.
CR542271 - Homo sapiens full open reading frame cDNA clone RZPDo834G0526D for gene HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; complete cds, without stopcodon.
KJ534867 - Homo sapiens clone HRAS_iso-A_adult-A06 Harvey rat sarcoma viral oncoprotein isoform A (HRAS) mRNA, partial cds, alternatively spliced.
KJ534868 - Homo sapiens clone HRAS_iso-A_fetal-F05 Harvey rat sarcoma viral oncoprotein isoform A (HRAS) mRNA, partial cds, alternatively spliced.
AJ437024 - Homo sapiens mRNA for p19 H-RasIDX protein (H-RAS gene).
KJ891390 - Synthetic construct Homo sapiens clone ccsbBroadEn_00784 HRAS gene, encodes complete protein.
KR709969 - Synthetic construct Homo sapiens clone CCSBHm_00008586 HRAS (HRAS) mRNA, encodes complete protein.
KR709970 - Synthetic construct Homo sapiens clone CCSBHm_00008588 HRAS (HRAS) mRNA, encodes complete protein.
KR709971 - Synthetic construct Homo sapiens clone CCSBHm_00008589 HRAS (HRAS) mRNA, encodes complete protein.
KR709972 - Synthetic construct Homo sapiens clone CCSBHm_00008591 HRAS (HRAS) mRNA, encodes complete protein.
DD170630 - ACYCLIC LINKER-CONTAINING OLIGONUCLEOTIDES AND USES THEREOF.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
h_egfPathway - EGF Signaling Pathway
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway
h_keratinocytePathway - Keratinocyte Differentiation
h_mCalpainPathway - mCalpain and friends in Cell motility
h_reckPathway - Inhibition of Matrix Metalloproteinases
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_bcrPathway - BCR Signaling Pathway
h_il2Pathway - IL 2 signaling pathway
h_mPRPathway - How Progesterone Initiates the Oocyte Maturation
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_tcrPathway - T Cell Receptor Signaling Pathway
h_tffPathway - Trefoil Factors Initiate Mucosal Healing
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
h_malPathway - Role of MAL in Rho-Mediated Activation of SRF
h_rasPathway - Ras Signaling Pathway
h_sppaPathway - Aspirin Blocks Signaling Pathway Involved in Platelet Activation
h_integrinPathway - Integrin Signaling Pathway
h_mapkPathway - MAPKinase Signaling Pathway
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_igf1Pathway - IGF-1 Signaling Pathway
h_il3Pathway - IL 3 signaling pathway
h_il6Pathway - IL 6 signaling pathway
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_trkaPathway - Trka Receptor Signaling Pathway
h_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
h_epoPathway - EPO Signaling Pathway
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_pmlPathway - Regulation of transcriptional activity by PML
h_sam68Pathway - Regulation of Splicing through Sam68
h_CCR3Pathway - CCR3 signaling in Eosinophils
h_TPOPathway - TPO Signaling Pathway
h_cxcr4Pathway - CXCR4 Signaling Pathway
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_ghPathway - Growth Hormone Signaling Pathway
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_insulinPathway - Insulin Signaling Pathway
h_longevityPathway - The IGF-1 Receptor and Longevity
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_spryPathway - Sprouty regulation of tyrosine kinase signals
h_bArrestin-srcPathway - Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling
h_crebPathway - Transcription factor CREB and its extracellular signals
h_etsPathway - METS affect on Macrophage Differentiation
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_ngfPathway - Nerve growth factor pathway (NGF)
h_pdgfPathway - PDGF Signaling Pathway
h_vegfPathway - VEGF, Hypoxia, and Angiogenesis

Reactome (by CSHL, EBI, and GO)

Protein P01112 (Reactome details) participates in the following event(s):

R-HSA-442732 Ras activation
R-HSA-4093331 Ras:GTP binds p120-RasGAP
R-HSA-170986 Ral-GDS binds to Ras-GTP
R-HSA-5624494 RAF1 binds p21 RAS:GTP
R-HSA-5658435 RAS GAPs bind RAS:GTP
R-HSA-5672950 "Activator" RAF:YWHAB dimer binds RAS:GTP
R-HSA-5674018 BRAP binds RAS:GTP
R-HSA-8981355 RASA1 binds RAS:GTP
R-HSA-109807 GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
R-HSA-109817 GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
R-HSA-177938 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
R-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
R-HSA-186834 Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)
R-HSA-210977 Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
R-HSA-392054 NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
R-HSA-1168636 p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
R-HSA-1225951 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
R-HSA-1250383 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
R-HSA-1250463 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
R-HSA-1250498 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
R-HSA-1306972 RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
R-HSA-1433471 Activation of RAS by p-KIT bound SOS1
R-HSA-2179407 SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
R-HSA-2424477 SOS mediated nucleotide exchange of RAS (SHC)
R-HSA-5218845 p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
R-HSA-5637806 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655326 Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655347 Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
R-HSA-8851827 RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
R-HSA-8851877 RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
R-HSA-8851899 RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
R-HSA-8853307 FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-8941613 Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
R-HSA-8941618 Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
R-HSA-8941623 Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
R-HSA-8941628 Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
R-HSA-9026891 NTRK2 activates RAS signaling through SHC1
R-HSA-5658231 RAS GAPs stimulate RAS GTPase activity
R-HSA-8981353 RASA1 stimulates RAS GTPase activity
R-HSA-6802915 Moderate kinase activity BRAF mutants bind RAS:GTP
R-HSA-4093339 p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
R-HSA-6802908 RAS mutants bind inactive RAF
R-HSA-6802937 Inactive BRAF mutants bind mutant RAS:GTP
R-HSA-5624492 PAK phosphorylates p21 RAF1 on S338
R-HSA-5672980 Dissociation of RAS:RAF complex
R-HSA-5672966 RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
R-HSA-5674022 BRAP autoubiquitinates
R-HSA-5675431 PP2A dephosphorylates RAF1
R-HSA-5675417 PEBP1 binds activated RAF1
R-HSA-5675433 PP5 dephosphorylates RAF1 S338
R-HSA-6802916 RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
R-HSA-8936676 Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6803230 Dissociation of moderate activity BRAF complexes
R-HSA-6802924 RAF is phosphorylated downstream of oncogenic RAS
R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex
R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
R-HSA-6802941 RAF is paradoxically phosphorylated downstream of kinase-inactive RAF
R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes
R-HSA-8936731 Inactive BRAF mutants:mutant RAS:GTP bind RAF1
R-HSA-171026 Guanine nucleotide exchange on RAL
R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex
R-HSA-5672969 Phosphorylation of RAF
R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS
R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
R-HSA-5672978 RAF phosphorylates MAP2K dimer
R-HSA-5672973 MAP2Ks phosphorylate MAPKs
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-171007 p38MAPK events
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5673000 RAF activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-112412 SOS-mediated signalling
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-186763 Downstream signal transduction
R-HSA-210993 Tie2 Signaling
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-1169092 Activation of RAS in B cells
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2424491 DAP12 signaling
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-167044 Signalling to RAS
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-8848021 Signaling by PTK6
R-HSA-74752 Signaling by Insulin receptor
R-HSA-112399 IRS-mediated signalling
R-HSA-177929 Signaling by EGFR
R-HSA-186797 Signaling by PDGF
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-422475 Axon guidance
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-1236394 Signaling by ERBB4
R-HSA-1227986 Signaling by ERBB2
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2172127 DAP12 interactions
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5637812 Signaling by EGFRvIII in Cancer
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-187687 Signalling to ERKs
R-HSA-2428924 IGF1R signaling cascade
R-HSA-6806834 Signaling by MET
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-438064 Post NMDA receptor activation events
R-HSA-168249 Innate Immune System
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-109582 Hemostasis
R-HSA-1266738 Developmental Biology
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-162582 Signal Transduction
R-HSA-416476 G alpha (q) signalling events
R-HSA-194138 Signaling by VEGF
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-5663202 Diseases of signal transduction
R-HSA-5683057 MAPK family signaling cascades
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-166520 Signaling by NTRKs
R-HSA-442755 Activation of NMDA receptor and postsynaptic events
R-HSA-168256 Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-388396 GPCR downstream signalling
R-HSA-190236 Signaling by FGFR
R-HSA-1643685 Disease
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-372790 Signaling by GPCR
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: B5BUA0, ENST00000417302.1, ENST00000417302.2, ENST00000417302.3, ENST00000417302.4, ENST00000417302.5, ENST00000417302.6, HRAS1, NM_176795, P01112, Q14080, Q6FHV9, Q9BR65, Q9UCE2, RASH_HUMAN, uc319myt.1, uc319myt.2
UCSC ID: ENST00000417302.7_8
RefSeq Accession: NM_176795.5
Protein: P01112 (aka RASH_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene HRAS:
costello (HRAS-Related Costello Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.