ID:HRK_HUMAN DESCRIPTION: RecName: Full=Activator of apoptosis harakiri; AltName: Full=BH3-interacting domain-containing protein 3; AltName: Full=Neuronal death protein DP5; FUNCTION: Promotes apoptosis. SUBUNIT: Interacts with BCL2 and BCL2L1. Interacts with C1QBP. INTERACTION: Q07817-1:BCL2L1; NbExp=2; IntAct=EBI-701322, EBI-287195; SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. Mitochondrion. DOMAIN: The BH3 motif is required for the induction of cell death.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00198
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0032464 positive regulation of protein homooligomerization GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0090200 positive regulation of release of cytochrome c from mitochondria
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
