Human Gene HRNR (ENST00000368801.4_8) from GENCODE V47lift37
  Description: hornerin (from RefSeq NM_001009931.3)
Gencode Transcript: ENST00000368801.4_8
Gencode Gene: ENSG00000197915.7_9
Transcript (Including UTRs)
   Position: hg19 chr1:152,184,552-152,196,669 Size: 12,118 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr1:152,185,552-152,195,729 Size: 10,178 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:152,184,552-152,196,669)mRNA (may differ from genome)Protein (2850 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HORN_HUMAN
DESCRIPTION: RecName: Full=Hornerin;
FUNCTION: May play a role in cornification.
SUBCELLULAR LOCATION: Cytoplasmic granule (By similarity). Note=Found in keratohyalin granules in the granular cells of the epidermis (By similarity).
TISSUE SPECIFICITY: Expressed in psoriatic and regenerating skin after wounding.
PTM: Processed during the process of epidermal differentiation (By similarity).
SIMILARITY: Belongs to the S100-fused protein family.
SIMILARITY: In the N-terminal section; belongs to the S-100 family.
SIMILARITY: Contains 2 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.33 RPKM in Testis
Total median expression: 4.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3076-0.096 Picture PostScript Text
3' UTR -220.401000-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR020922 - Nucleoside-triphosphatase
IPR001240 - PRAI
IPR001751 - S100/CaBP-9k_CS
IPR013787 - S100_Ca-bd_sub

Pfam Domains:
PF01023 - S-100/ICaBP type calcium binding domain

SCOP Domains:
47473 - EF-hand

ModBase Predicted Comparative 3D Structure on Q86YZ3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding

Biological Process:
GO:0007275 multicellular organism development
GO:0031424 keratinization
GO:0043163 cell envelope organization
GO:0043312 neutrophil degranulation
GO:0061436 establishment of skin barrier

Cellular Component:
GO:0001533 cornified envelope
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035578 azurophil granule lumen
GO:0036457 keratohyalin granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AY396741 - Homo sapiens hornerin precursor mRNA, complete cds.
AB104446 - Homo sapiens mRNA for hornerin, partial cds.
JD345975 - Sequence 326999 from Patent EP1572962.
JD433149 - Sequence 414173 from Patent EP1572962.
JD062778 - Sequence 43802 from Patent EP1572962.
JD359793 - Sequence 340817 from Patent EP1572962.
JD046953 - Sequence 27977 from Patent EP1572962.
JD196778 - Sequence 177802 from Patent EP1572962.
JD082979 - Sequence 64003 from Patent EP1572962.
JD037629 - Sequence 18653 from Patent EP1572962.
JD349802 - Sequence 330826 from Patent EP1572962.
JD527782 - Sequence 508806 from Patent EP1572962.
JD203004 - Sequence 184028 from Patent EP1572962.
JD214097 - Sequence 195121 from Patent EP1572962.
JD276630 - Sequence 257654 from Patent EP1572962.
JD079268 - Sequence 60292 from Patent EP1572962.
JD239750 - Sequence 220774 from Patent EP1572962.
JD040540 - Sequence 21564 from Patent EP1572962.
JD151903 - Sequence 132927 from Patent EP1572962.
JD080438 - Sequence 61462 from Patent EP1572962.
JD459318 - Sequence 440342 from Patent EP1572962.
JD544885 - Sequence 525909 from Patent EP1572962.
JD206984 - Sequence 188008 from Patent EP1572962.
JD214097 - Sequence 195121 from Patent EP1572962.
JD276630 - Sequence 257654 from Patent EP1572962.
JD079268 - Sequence 60292 from Patent EP1572962.
JD040540 - Sequence 21564 from Patent EP1572962.
JD151903 - Sequence 132927 from Patent EP1572962.
JD080438 - Sequence 61462 from Patent EP1572962.
JD459318 - Sequence 440342 from Patent EP1572962.
JD544885 - Sequence 525909 from Patent EP1572962.
JD206984 - Sequence 188008 from Patent EP1572962.
JD214097 - Sequence 195121 from Patent EP1572962.
JD276630 - Sequence 257654 from Patent EP1572962.
JD079268 - Sequence 60292 from Patent EP1572962.
JD239750 - Sequence 220774 from Patent EP1572962.
JD040540 - Sequence 21564 from Patent EP1572962.
JD151903 - Sequence 132927 from Patent EP1572962.
JD544885 - Sequence 525909 from Patent EP1572962.
JD206984 - Sequence 188008 from Patent EP1572962.
JD214097 - Sequence 195121 from Patent EP1572962.
JD276630 - Sequence 257654 from Patent EP1572962.
JD079268 - Sequence 60292 from Patent EP1572962.
JD040540 - Sequence 21564 from Patent EP1572962.
JD151903 - Sequence 132927 from Patent EP1572962.
JD080438 - Sequence 61462 from Patent EP1572962.
JD459318 - Sequence 440342 from Patent EP1572962.
JD544885 - Sequence 525909 from Patent EP1572962.
JD206984 - Sequence 188008 from Patent EP1572962.
JD079268 - Sequence 60292 from Patent EP1572962.
JD239750 - Sequence 220774 from Patent EP1572962.
JD151903 - Sequence 132927 from Patent EP1572962.
JD080438 - Sequence 61462 from Patent EP1572962.
JD459318 - Sequence 440342 from Patent EP1572962.
JD276630 - Sequence 257654 from Patent EP1572962.
AB180729 - Homo sapiens mRNA for Hornerin, partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86YZ3 (Reactome details) participates in the following event(s):

R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000368801.1, ENST00000368801.2, ENST00000368801.3, HORN_HUMAN, NM_001009931, Q5DT20, Q5U1F4, Q86YZ3, S100A18, uc318hbp.1, uc318hbp.2
UCSC ID: ENST00000368801.4_8
RefSeq Accession: NM_001009931.3
Protein: Q86YZ3 (aka HORN_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.