Human Gene HSP90B1 (ENST00000299767.10_4) from GENCODE V47lift37
  Description: heat shock protein 90 beta family member 1 (from RefSeq NM_003299.3)
Gencode Transcript: ENST00000299767.10_4
Gencode Gene: ENSG00000166598.16_12
Transcript (Including UTRs)
   Position: hg19 chr12:104,324,188-104,341,704 Size: 17,517 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr12:104,324,294-104,341,440 Size: 17,147 Coding Exon Count: 18 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:104,324,188-104,341,704)mRNA (may differ from genome)Protein (803 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HSP90B1
Diseases sorted by gene-association score: myasthenic syndrome, congenital, 13, with tubular aggregates (11), pelizaeus-merzbacher-like disease (7), oral cavity cancer (6), growth hormone deficiency, isolated, type ii (5), bipolar disorder (5), prostate cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 521.60 RPKM in Thyroid
Total median expression: 7854.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.50106-0.420 Picture PostScript Text
3' UTR -58.30264-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  LF208849 - JP 2014500723-A/16352: Polycomb-Associated Non-Coding RNAs.
AJ890084 - Homo sapiens mRNA for tumor rejection antigen (gp96) 1 (TRA1 gene).
AK025459 - Homo sapiens cDNA: FLJ21806 fis, clone HEP00829, highly similar to HSTRA1 Human tra1 mRNA for human homologue of murine tumor rejection antigen gp96.
GQ900941 - Homo sapiens clone HEL-T-53 epididymis secretory sperm binding protein mRNA, complete cds.
AK298996 - Homo sapiens cDNA FLJ58927 complete cds, highly similar to Endoplasmin precursor (Heat shock protein 90 kDa beta member 1).
AK300521 - Homo sapiens cDNA FLJ58626 complete cds, highly similar to Endoplasmin precursor (Heat shock protein 90 kDa beta member 1).
X15187 - Homo sapiens tra1 mRNA for human homologue of murine tumor rejection antigen gp96.
BC066656 - Homo sapiens heat shock protein 90kDa beta (Grp94), member 1, mRNA (cDNA clone MGC:75130 IMAGE:6165138), complete cds.
EU794608 - Homo sapiens epididymis luminal protein 35 (HEL35) mRNA, complete cds.
FJ460515 - Homo sapiens epididymis secretory sperm binding protein Li 125m (HEL-S-125m) mRNA, complete cds.
BC009195 - Homo sapiens heat shock protein 90kDa beta (Grp94), member 1, mRNA (cDNA clone IMAGE:3938823), complete cds.
AB209534 - Homo sapiens mRNA for tumor rejection antigen (gp96) 1 variant protein.
AY040226 - Homo sapiens heat shock protein gp96 precursor, mRNA, partial cds.
AK295262 - Homo sapiens cDNA FLJ58812 complete cds, highly similar to Endoplasmin precursor (Heat shock protein 90kDa beta member 1).
MA444426 - JP 2018138019-A/16352: Polycomb-Associated Non-Coding RNAs.
AH007363 - Homo sapiens tumor rejection antigen/endoplasmic reticular heat shock protein gp96 homolog (tumor rejection antigen/endoplasmic reticular heat shock protein gp96 homolog) mRNA, complete cds.
HZ409114 - JP 2015528002-A/1711: CHIRAL CONTROL.
LG052448 - KR 1020150036642-A/1714: CHIRAL CONTROL.
JD465922 - Sequence 446946 from Patent EP1572962.
JD255254 - Sequence 236278 from Patent EP1572962.
LF323417 - JP 2014500723-A/130920: Polycomb-Associated Non-Coding RNAs.
JD139902 - Sequence 120926 from Patent EP1572962.
KJ904577 - Synthetic construct Homo sapiens clone ccsbBroadEn_13971 HSP90B1 gene, encodes complete protein.
LF323413 - JP 2014500723-A/130916: Polycomb-Associated Non-Coding RNAs.
LF323411 - JP 2014500723-A/130914: Polycomb-Associated Non-Coding RNAs.
LF323409 - JP 2014500723-A/130912: Polycomb-Associated Non-Coding RNAs.
LF323408 - JP 2014500723-A/130911: Polycomb-Associated Non-Coding RNAs.
LF323407 - JP 2014500723-A/130910: Polycomb-Associated Non-Coding RNAs.
LF323406 - JP 2014500723-A/130909: Polycomb-Associated Non-Coding RNAs.
LF323404 - JP 2014500723-A/130907: Polycomb-Associated Non-Coding RNAs.
JD025693 - Sequence 6717 from Patent EP1572962.
LF323403 - JP 2014500723-A/130906: Polycomb-Associated Non-Coding RNAs.
MA558994 - JP 2018138019-A/130920: Polycomb-Associated Non-Coding RNAs.
MA558990 - JP 2018138019-A/130916: Polycomb-Associated Non-Coding RNAs.
MA558988 - JP 2018138019-A/130914: Polycomb-Associated Non-Coding RNAs.
MA558986 - JP 2018138019-A/130912: Polycomb-Associated Non-Coding RNAs.
MA558985 - JP 2018138019-A/130911: Polycomb-Associated Non-Coding RNAs.
MA558984 - JP 2018138019-A/130910: Polycomb-Associated Non-Coding RNAs.
MA558983 - JP 2018138019-A/130909: Polycomb-Associated Non-Coding RNAs.
MA558981 - JP 2018138019-A/130907: Polycomb-Associated Non-Coding RNAs.
MA558980 - JP 2018138019-A/130906: Polycomb-Associated Non-Coding RNAs.
MB407455 - WO 2019159884-A/945: Kit, device, and method for detection of dementia.
MB473147 - WO 2019208671-A/546: Kit or device and method for detecting bladder cancer.
MB472892 - WO 2019208671-A/291: Kit or device and method for detecting bladder cancer.
LF323401 - JP 2014500723-A/130904: Polycomb-Associated Non-Coding RNAs.
AF087988 - Homo sapiens full length insert cDNA clone YX27D10.
LF323400 - JP 2014500723-A/130903: Polycomb-Associated Non-Coding RNAs.
LF323399 - JP 2014500723-A/130902: Polycomb-Associated Non-Coding RNAs.
LF323396 - JP 2014500723-A/130899: Polycomb-Associated Non-Coding RNAs.
LF208847 - JP 2014500723-A/16350: Polycomb-Associated Non-Coding RNAs.
LF323395 - JP 2014500723-A/130898: Polycomb-Associated Non-Coding RNAs.
LF323394 - JP 2014500723-A/130897: Polycomb-Associated Non-Coding RNAs.
LF323393 - JP 2014500723-A/130896: Polycomb-Associated Non-Coding RNAs.
LF323392 - JP 2014500723-A/130895: Polycomb-Associated Non-Coding RNAs.
LF323390 - JP 2014500723-A/130893: Polycomb-Associated Non-Coding RNAs.
LF323389 - JP 2014500723-A/130892: Polycomb-Associated Non-Coding RNAs.
LF323386 - JP 2014500723-A/130889: Polycomb-Associated Non-Coding RNAs.
LF323385 - JP 2014500723-A/130888: Polycomb-Associated Non-Coding RNAs.
LF323384 - JP 2014500723-A/130887: Polycomb-Associated Non-Coding RNAs.
JD207175 - Sequence 188199 from Patent EP1572962.
JD191087 - Sequence 172111 from Patent EP1572962.
LF323383 - JP 2014500723-A/130886: Polycomb-Associated Non-Coding RNAs.
JD368120 - Sequence 349144 from Patent EP1572962.
LF323382 - JP 2014500723-A/130885: Polycomb-Associated Non-Coding RNAs.
MA558978 - JP 2018138019-A/130904: Polycomb-Associated Non-Coding RNAs.
MA558977 - JP 2018138019-A/130903: Polycomb-Associated Non-Coding RNAs.
MA558976 - JP 2018138019-A/130902: Polycomb-Associated Non-Coding RNAs.
MA558973 - JP 2018138019-A/130899: Polycomb-Associated Non-Coding RNAs.
MA558972 - JP 2018138019-A/130898: Polycomb-Associated Non-Coding RNAs.
MA558971 - JP 2018138019-A/130897: Polycomb-Associated Non-Coding RNAs.
MA558970 - JP 2018138019-A/130896: Polycomb-Associated Non-Coding RNAs.
MA558969 - JP 2018138019-A/130895: Polycomb-Associated Non-Coding RNAs.
MA558967 - JP 2018138019-A/130893: Polycomb-Associated Non-Coding RNAs.
MA558966 - JP 2018138019-A/130892: Polycomb-Associated Non-Coding RNAs.
MA558963 - JP 2018138019-A/130889: Polycomb-Associated Non-Coding RNAs.
MA558962 - JP 2018138019-A/130888: Polycomb-Associated Non-Coding RNAs.
MA558961 - JP 2018138019-A/130887: Polycomb-Associated Non-Coding RNAs.
MA558960 - JP 2018138019-A/130886: Polycomb-Associated Non-Coding RNAs.
MA558959 - JP 2018138019-A/130885: Polycomb-Associated Non-Coding RNAs.
MA444424 - JP 2018138019-A/16350: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000299767.1, ENST00000299767.2, ENST00000299767.3, ENST00000299767.4, ENST00000299767.5, ENST00000299767.6, ENST00000299767.7, ENST00000299767.8, ENST00000299767.9, hCG_21864 , HEL-S-125m , HEL35 , HSP90B1 , NM_003299, uc317mlw.1, uc317mlw.2, V9HWP2, V9HWP2_HUMAN
UCSC ID: ENST00000299767.10_4
RefSeq Accession: NM_003299.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.