Human Gene HSPA1A (ENST00000375651.7_4) from GENCODE V47lift37
  Description: heat shock protein family A (Hsp70) member 1A (from RefSeq NM_005345.6)
Gencode Transcript: ENST00000375651.7_4
Gencode Gene: ENSG00000204389.10_8
Transcript (Including UTRs)
   Position: hg19 chr6:31,783,320-31,785,719 Size: 2,400 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr6:31,783,534-31,785,459 Size: 1,926 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,783,320-31,785,719)mRNA (may differ from genome)Protein (641 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HSPA1A
Diseases sorted by gene-association score: carotid artery occlusion (22), transient cerebral ischemia (18), mulibrey nanism (8), tuberculoid leprosy (7), ariboflavinosis (5), acute mountain sickness (5), occlusion precerebral artery (5), ischemia (4), heart disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.20214-0.328 Picture PostScript Text
3' UTR -42.90260-0.165 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  FJ224292 - Homo sapiens epididymis secretory protein Li 103 (HEL-S-103) mRNA, complete cds.
AX036039 - Sequence 2 from Patent WO0053785.
BD273754 - Expression.
DQ409329 - Homo sapiens heat shock protein (HSP70) mRNA, 5' UTR.
AK295398 - Homo sapiens cDNA FLJ54328 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK298078 - Homo sapiens cDNA FLJ53071 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK304652 - Homo sapiens cDNA FLJ54408 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK304618 - Homo sapiens cDNA FLJ54407 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK303980 - Homo sapiens cDNA FLJ54342 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK225692 - Homo sapiens mRNA for Heat shock 70 kDa protein 1 variant, clone: SYN07517.
AK096017 - Homo sapiens cDNA FLJ38698 fis, clone KIDNE2002015, highly similar to HEAT SHOCK 70 KDA PROTEIN 1.
AK291295 - Homo sapiens cDNA FLJ75127 complete cds, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNA.
AK294182 - Homo sapiens cDNA FLJ54303 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK298098 - Homo sapiens cDNA FLJ53752 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK301574 - Homo sapiens cDNA FLJ54392 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK225699 - Homo sapiens mRNA for Heat shock 70 kDa protein 1 variant, clone: SYN09532.
AK298056 - Homo sapiens cDNA FLJ54370 complete cds, highly similar to Heat shock 70 kDa protein 1.
AK301243 - Homo sapiens cDNA FLJ54389 complete cds, highly similar to Heat shock 70 kDa protein 1.
AB209818 - Homo sapiens mRNA for heat shock 70kDa protein 1A variant protein.
BC002453 - Homo sapiens heat shock 70kDa protein 1A, mRNA (cDNA clone MGC:1309 IMAGE:3345864), complete cds.
GQ891470 - Homo sapiens clone HEL-S-191 epididymis secretory sperm binding protein mRNA, complete cds.
DQ596815 - Homo sapiens piRNA piR-34881, complete sequence.
JD180856 - Sequence 161880 from Patent EP1572962.
JD538175 - Sequence 519199 from Patent EP1572962.
JD248250 - Sequence 229274 from Patent EP1572962.
JD103981 - Sequence 85005 from Patent EP1572962.
CU679297 - Synthetic construct Homo sapiens gateway clone IMAGE:100017440 5' read HSPA1A mRNA.
KJ897012 - Synthetic construct Homo sapiens clone ccsbBroadEn_06406 HSPA1A gene, encodes complete protein.
AB527245 - Synthetic construct DNA, clone: pF1KB9773, Homo sapiens HSPA1A gene for heat shock 70kDa protein 1A, without stop codon, in Flexi system.
DQ896426 - Synthetic construct Homo sapiens clone IMAGE:100010886; FLH194198.01L; RZPDo839G0769D heat shock 70kDa protein 1A (HSPA1A) gene, encodes complete protein.
EU176434 - Synthetic construct Homo sapiens clone IMAGE:100006510; FLH194202.01X; RZPDo839G0779D heat shock 70kDa protein 1A (HSPA1A) gene, encodes complete protein.
JD024959 - Sequence 5983 from Patent EP1572962.
JD034422 - Sequence 15446 from Patent EP1572962.
L19690 - Human MHC class I mRNA sequence.
JD552181 - Sequence 533205 from Patent EP1572962.
JD551319 - Sequence 532343 from Patent EP1572962.
JD444720 - Sequence 425744 from Patent EP1572962.
JD236193 - Sequence 217217 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_tidPathway - Chaperones modulate interferon Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: B4E3B6, ENST00000375651.1, ENST00000375651.2, ENST00000375651.3, ENST00000375651.4, ENST00000375651.5, ENST00000375651.6, HS71A_HUMAN, HSP72 , HSPA1, HSX70, NM_005345, P08107, P0DMV8, P19790, Q5JQI4, Q5SP17, Q9UQL9, Q9UQM0, uc318mkp.1, uc318mkp.2
UCSC ID: ENST00000375651.7_4
RefSeq Accession: NM_005345.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.