ID:GRP75_HUMAN DESCRIPTION: RecName: Full=Stress-70 protein, mitochondrial; AltName: Full=75 kDa glucose-regulated protein; Short=GRP-75; AltName: Full=Heat shock 70 kDa protein 9; AltName: Full=Mortalin; Short=MOT; AltName: Full=Peptide-binding protein 74; Short=PBP74; Flags: Precursor; FUNCTION: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. SUBUNIT: Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. INTERACTION: Q8WX92:COBRA1; NbExp=2; IntAct=EBI-354932, EBI-347721; P04637:TP53; NbExp=2; IntAct=EBI-354932, EBI-366083; O15350:TP73; NbExp=11; IntAct=EBI-354932, EBI-389606; SUBCELLULAR LOCATION: Mitochondrion. Nucleus, nucleolus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the heat shock protein 70 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hspa9b/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P38646
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK225488 - Homo sapiens mRNA for heat shock 70kDa protein 9B precursor variant, clone: JTH02057. BC030634 - Homo sapiens heat shock 70kDa protein 9 (mortalin), mRNA (cDNA clone IMAGE:3941210), partial cds. BC000478 - Homo sapiens heat shock 70kDa protein 9 (mortalin), mRNA (cDNA clone MGC:8684 IMAGE:2964588), complete cds. BC024034 - Homo sapiens heat shock 70kDa protein 9 (mortalin), mRNA (cDNA clone MGC:4500 IMAGE:2964588), complete cds. LP895536 - Sequence 400 from Patent EP3253886. L11066 - Human mRNA sequence. JD298195 - Sequence 279219 from Patent EP1572962. JD026492 - Sequence 7516 from Patent EP1572962. JD029565 - Sequence 10589 from Patent EP1572962. JD519221 - Sequence 500245 from Patent EP1572962. JD091113 - Sequence 72137 from Patent EP1572962. JD551876 - Sequence 532900 from Patent EP1572962. JD151709 - Sequence 132733 from Patent EP1572962. JD036782 - Sequence 17806 from Patent EP1572962. JD450781 - Sequence 431805 from Patent EP1572962. AK297795 - Homo sapiens cDNA FLJ51903 complete cds, highly similar to Stress-70 protein, mitochondrial precursor. AK222758 - Homo sapiens mRNA for heat shock 70kDa protein 9B precursor variant, clone: HEP01066. JD279888 - Sequence 260912 from Patent EP1572962. AK297897 - Homo sapiens cDNA FLJ51907 complete cds, highly similar to Stress-70 protein, mitochondrial precursor. FJ224291 - Homo sapiens epididymis secretory sperm binding protein Li 124m (HEL-S-124m) mRNA, complete cds. L15189 - Homo sapiens mitochondrial HSP75 mRNA, complete cds. JD049316 - Sequence 30340 from Patent EP1572962. JD508023 - Sequence 489047 from Patent EP1572962. DQ480334 - Homo sapiens catecholamine-regulated protein 40 mRNA, complete cds, alternatively spliced. GQ891353 - Homo sapiens clone HEL-S-1269g epididymis secretory sperm binding protein mRNA, complete cds. AK315177 - Homo sapiens cDNA, FLJ96154, highly similar to Homo sapiens heat shock 70kDa protein 9B (mortalin-2) (HSPA9B),nuclear gene encoding mitochondrial protein, mRNA. JF432370 - Synthetic construct Homo sapiens clone IMAGE:100073567 heat shock 70kDa protein 9 (mortalin) (HSPA9) gene, encodes complete protein. KJ897017 - Synthetic construct Homo sapiens clone ccsbBroadEn_06411 HSPA9 gene, encodes complete protein. EU446981 - Synthetic construct Homo sapiens clone IMAGE:100070210; IMAGE:100012190; FLH258747.01L heat shock 70kDa protein 9 (mortalin) (HSPA9) gene, encodes complete protein. AB463063 - Synthetic construct DNA, clone: pF1KB3200, Homo sapiens HSPA9 gene for heat shock 70kDa protein 9, without stop codon, in Flexi system. AK293990 - Homo sapiens cDNA FLJ51811 complete cds, highly similar to Stress-70 protein, mitochondrial precursor. AK023317 - Homo sapiens cDNA FLJ13255 fis, clone OVARC1000800, moderately similar to MITOCHONDRIAL STRESS-70 PROTEIN PRECURSOR. CU674234 - Synthetic construct Homo sapiens gateway clone IMAGE:100020731 5' read HSPA9 mRNA. DQ185038 - Homo sapiens heat shock 70 kDa protein 9B mRNA, partial cds. JD338420 - Sequence 319444 from Patent EP1572962. JD271259 - Sequence 252283 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P38646 (Reactome details) participates in the following event(s):
R-HSA-1268022 TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space R-HSA-1299480 Precursor proteins enter TIMM23 PAM R-HSA-1299487 Precursor proteins enter TIMM23 SORT R-HSA-1299475 TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix R-HSA-1299482 TIMM23 SORT inserts proteins into inner membrane R-HSA-5251942 Hikeshi binds HSP70s:ATP R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm R-HSA-1299478 MPP cleaves targeting peptide (presequence) of matrix precursors R-HSA-1299476 MPP cleaves targeting peptide (presequence) of inner membrane precursors R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm R-HSA-8949613 Cristae formation R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-1268020 Mitochondrial protein import R-HSA-1592230 Mitochondrial biogenesis R-HSA-9020591 Interleukin-12 signaling R-HSA-392499 Metabolism of proteins R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-447115 Interleukin-12 family signaling R-HSA-3371556 Cellular response to heat stress R-HSA-449147 Signaling by Interleukins R-HSA-2262752 Cellular responses to stress R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-8953897 Cellular responses to external stimuli R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
