Human Gene HSPB1 (ENST00000248553.7_4) from GENCODE V47lift37
  Description: heat shock protein family B (small) member 1 (from RefSeq NM_001540.5)
Gencode Transcript: ENST00000248553.7_4
Gencode Gene: ENSG00000106211.11_14
Transcript (Including UTRs)
   Position: hg19 chr7:75,931,990-75,933,609 Size: 1,620 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr7:75,932,030-75,933,490 Size: 1,461 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:75,931,990-75,933,609)mRNA (may differ from genome)Protein (205 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HSPB1
Diseases sorted by gene-association score: charcot-marie-tooth disease, axonal, type 2f* (1667), neuropathy, distal hereditary motor, type iib* (1300), charcot-marie-tooth disease type 2f* (419), distal hereditary motor neuropathy, type ii* (247), charcot-marie-tooth disease* (209), roussy-levy syndrome* (100), distal hereditary motor neuropathy (21), alexander disease (19), tooth disease (17), machado-joseph disease (10), retinal ischemia (9), anterior spinal artery syndrome (8), ureteral obstruction (5), charcot-marie-tooth disease, axonal, type 2l (5), breast cancer (3), eye disease (2), ovarian cancer, somatic (1), amyotrophic lateral sclerosis 1 (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1783.37 RPKM in Esophagus - Mucosa
Total median expression: 19038.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.1040-0.177 Picture PostScript Text
3' UTR -18.70119-0.157 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  FJ224323 - Homo sapiens epididymis secretory protein Li 102 (HEL-S-102) mRNA, complete cds.
U90906 - Human clone 23827 heat shock protein mRNA, complete cds.
LP895571 - Sequence 435 from Patent EP3253886.
BC000510 - Homo sapiens heat shock 27kDa protein 1, mRNA (cDNA clone MGC:8509 IMAGE:2822325), complete cds.
BC012292 - Homo sapiens heat shock 27kDa protein 1, mRNA (cDNA clone MGC:21487 IMAGE:3862626), complete cds.
AF086135 - Homo sapiens full length insert cDNA clone ZA89B11.
X54079 - Human mRNA for heat shock protein HSP27.
JD405778 - Sequence 386802 from Patent EP1572962.
AK296890 - Homo sapiens cDNA FLJ52243 complete cds, highly similar to Heat-shock protein beta-1.
AK311894 - Homo sapiens cDNA, FLJ92160, Homo sapiens heat shock 27kDa protein 1 (HSPB1), mRNA.
JD433254 - Sequence 414278 from Patent EP1572962.
BC012768 - Homo sapiens heat shock 27kDa protein 1, mRNA (cDNA clone MGC:16252 IMAGE:3689220), complete cds.
BC073768 - Homo sapiens heat shock 27kDa protein 1, mRNA (cDNA clone MGC:88776 IMAGE:5444848), complete cds.
AB020027 - Homo sapiens HSP27 mRNA, complete cds.
AL050380 - Homo sapiens mRNA; cDNA DKFZp586P1322 (from clone DKFZp586P1322).
Z23090 - H.sapiens mRNA for 28 kDa heat shock protein.
DQ894489 - Synthetic construct Homo sapiens clone IMAGE:100008949; FLH263716.01L; RZPDo839D0299D heat shock 27kDa protein 1 (HSPB1) gene, encodes complete protein.
DQ896669 - Synthetic construct Homo sapiens clone IMAGE:100011129; FLH263661.01L; RZPDo839E01155D heat shock 27kDa protein 1 (HSPB1) gene, encodes complete protein.
DQ891304 - Synthetic construct Homo sapiens clone IMAGE:100003934; FLH263567.01X; RZPDo839D02100D heat shock 27kDa protein 1 (HSPB1) gene, encodes complete protein.
DQ893349 - Synthetic construct Homo sapiens clone IMAGE:100005979; FLH263580.01X; RZPDo839E01156D heat shock 27kDa protein 1 (HSPB1) gene, encodes complete protein.
AB528488 - Synthetic construct DNA, clone: pF1KB6909, Homo sapiens HSPB1 gene for heat shock 27kDa protein 1, without stop codon, in Flexi system.
CR407614 - Homo sapiens full open reading frame cDNA clone RZPDo834B022D for gene HSPB1, heat shock 27kDa protein 1 complete cds, without stopcodon.
BT019888 - Homo sapiens heat shock 27kDa protein 1 mRNA, complete cds.
CR536489 - Homo sapiens full open reading frame cDNA clone RZPDo834F0917D for gene HSPB1, heat shock 27kDa protein 1; complete cds, incl. stopcodon.
BC014920 - Homo sapiens, clone IMAGE:3906970, mRNA, partial cds.
JD020754 - Sequence 1778 from Patent EP1572962.
JD021515 - Sequence 2539 from Patent EP1572962.
JD033935 - Sequence 14959 from Patent EP1572962.
JD027711 - Sequence 8735 from Patent EP1572962.
X16477 - Human mRNA fragment for estrogen-regulated 24k protein.
AK311446 - Homo sapiens cDNA, FLJ18488.
S74571 - estrogen receptor-related protein=27-kda heat shock protein [human, mRNA Partial, 349 nt].
JD429452 - Sequence 410476 from Patent EP1572962.
JD400736 - Sequence 381760 from Patent EP1572962.
JD271262 - Sequence 252286 from Patent EP1572962.
JD368009 - Sequence 349033 from Patent EP1572962.
JD313039 - Sequence 294063 from Patent EP1572962.
MP202714 - Sequence 25 from Patent WO2019090263.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_hsp27Pathway - Stress Induction of HSP Regulation
h_mta3Pathway - Downregulated of MTA-3 in ER-negative Breast Tumors
h_p38mapkPathway - p38 MAPK Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000248553.1, ENST00000248553.2, ENST00000248553.3, ENST00000248553.4, ENST00000248553.5, ENST00000248553.6, HEL-S-102 , NM_001540, uc317exq.1, uc317exq.2, V9HW43, V9HW43_HUMAN
UCSC ID: ENST00000248553.7_4
RefSeq Accession: NM_001540.5

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene HSPB1:
cmt (Charcot-Marie-Tooth Hereditary Neuropathy Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.