Human Gene HUNK (ENST00000270112.7_4) from GENCODE V47lift37
  Description: hormonally up-regulated Neu-associated kinase (from RefSeq NM_014586.2)
Gencode Transcript: ENST00000270112.7_4
Gencode Gene: ENSG00000142149.9_8
Transcript (Including UTRs)
   Position: hg19 chr21:33,245,333-33,376,377 Size: 131,045 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr21:33,245,988-33,371,497 Size: 125,510 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:33,245,333-33,376,377)mRNA (may differ from genome)Protein (714 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HUNK_HUMAN
DESCRIPTION: RecName: Full=Hormonally up-regulated neu tumor-associated kinase; EC=2.7.11.1; AltName: Full=B19; AltName: Full=Serine/threonine-protein kinase MAK-V;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.01 RPKM in Kidney - Cortex
Total median expression: 27.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -363.50655-0.555 Picture PostScript Text
3' UTR -1818.504880-0.373 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF01163 - RIO1 family
PF03109 - ABC1 atypical kinase-like domain
PF06293 - Lipopolysaccharide kinase (Kdo/WaaP) family
PF07714 - Protein tyrosine and serine/threonine kinase
PF14531 - Kinase-like

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on P57058
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF210663 - JP 2014500723-A/18166: Polycomb-Associated Non-Coding RNAs.
AJ271722 - Homo sapiens mRNA for serine/threonine protein kinase MAK-V (MAK-V gene).
BC156532 - Synthetic construct Homo sapiens clone IMAGE:100063168, MGC:190711 hormonally up-regulated Neu-associated kinase (HUNK) mRNA, encodes complete protein.
BC172525 - Synthetic construct Homo sapiens clone IMAGE:100069219, MGC:199230 hormonally up-regulated Neu-associated kinase (HUNK) mRNA, encodes complete protein.
MA446240 - JP 2018138019-A/18166: Polycomb-Associated Non-Coding RNAs.
LF212684 - JP 2014500723-A/20187: Polycomb-Associated Non-Coding RNAs.
JD461483 - Sequence 442507 from Patent EP1572962.
JD200970 - Sequence 181994 from Patent EP1572962.
JD409062 - Sequence 390086 from Patent EP1572962.
JD448363 - Sequence 429387 from Patent EP1572962.
JD141521 - Sequence 122545 from Patent EP1572962.
JD278037 - Sequence 259061 from Patent EP1572962.
JD468784 - Sequence 449808 from Patent EP1572962.
JD138628 - Sequence 119652 from Patent EP1572962.
JD129514 - Sequence 110538 from Patent EP1572962.
MA448261 - JP 2018138019-A/20187: Polycomb-Associated Non-Coding RNAs.
JD486008 - Sequence 467032 from Patent EP1572962.
JD052505 - Sequence 33529 from Patent EP1572962.
JD116370 - Sequence 97394 from Patent EP1572962.
LF339877 - JP 2014500723-A/147380: Polycomb-Associated Non-Coding RNAs.
JD358039 - Sequence 339063 from Patent EP1572962.
JD555408 - Sequence 536432 from Patent EP1572962.
JD164245 - Sequence 145269 from Patent EP1572962.
JD285751 - Sequence 266775 from Patent EP1572962.
JD234603 - Sequence 215627 from Patent EP1572962.
JD560515 - Sequence 541539 from Patent EP1572962.
JD039441 - Sequence 20465 from Patent EP1572962.
JD049927 - Sequence 30951 from Patent EP1572962.
JD189654 - Sequence 170678 from Patent EP1572962.
JD225112 - Sequence 206136 from Patent EP1572962.
JD443546 - Sequence 424570 from Patent EP1572962.
JD107114 - Sequence 88138 from Patent EP1572962.
JD457236 - Sequence 438260 from Patent EP1572962.
JD248273 - Sequence 229297 from Patent EP1572962.
JD245674 - Sequence 226698 from Patent EP1572962.
JD209832 - Sequence 190856 from Patent EP1572962.
JD351357 - Sequence 332381 from Patent EP1572962.
JD058066 - Sequence 39090 from Patent EP1572962.
JD082614 - Sequence 63638 from Patent EP1572962.
JD453176 - Sequence 434200 from Patent EP1572962.
JD103581 - Sequence 84605 from Patent EP1572962.
JD330578 - Sequence 311602 from Patent EP1572962.
JD373830 - Sequence 354854 from Patent EP1572962.
JD384932 - Sequence 365956 from Patent EP1572962.
JD564217 - Sequence 545241 from Patent EP1572962.
JD396291 - Sequence 377315 from Patent EP1572962.
JD369325 - Sequence 350349 from Patent EP1572962.
JD120335 - Sequence 101359 from Patent EP1572962.
JD553704 - Sequence 534728 from Patent EP1572962.
JD376232 - Sequence 357256 from Patent EP1572962.
JD495345 - Sequence 476369 from Patent EP1572962.
JD259447 - Sequence 240471 from Patent EP1572962.
JD543671 - Sequence 524695 from Patent EP1572962.
JD208437 - Sequence 189461 from Patent EP1572962.
LF339878 - JP 2014500723-A/147381: Polycomb-Associated Non-Coding RNAs.
JD062087 - Sequence 43111 from Patent EP1572962.
JD201522 - Sequence 182546 from Patent EP1572962.
JD444200 - Sequence 425224 from Patent EP1572962.
JD463494 - Sequence 444518 from Patent EP1572962.
JD289023 - Sequence 270047 from Patent EP1572962.
JD289024 - Sequence 270048 from Patent EP1572962.
JD522491 - Sequence 503515 from Patent EP1572962.
JD187334 - Sequence 168358 from Patent EP1572962.
JD425427 - Sequence 406451 from Patent EP1572962.
JD425428 - Sequence 406452 from Patent EP1572962.
JD277669 - Sequence 258693 from Patent EP1572962.
JD482739 - Sequence 463763 from Patent EP1572962.
JD228634 - Sequence 209658 from Patent EP1572962.
JD545461 - Sequence 526485 from Patent EP1572962.
JD486367 - Sequence 467391 from Patent EP1572962.
JD144143 - Sequence 125167 from Patent EP1572962.
JD136202 - Sequence 117226 from Patent EP1572962.
JD079593 - Sequence 60617 from Patent EP1572962.
JD326652 - Sequence 307676 from Patent EP1572962.
JD326843 - Sequence 307867 from Patent EP1572962.
JD430401 - Sequence 411425 from Patent EP1572962.
JD430402 - Sequence 411426 from Patent EP1572962.
JD177464 - Sequence 158488 from Patent EP1572962.
JD096382 - Sequence 77406 from Patent EP1572962.
JD332053 - Sequence 313077 from Patent EP1572962.
JD447737 - Sequence 428761 from Patent EP1572962.
JD085169 - Sequence 66193 from Patent EP1572962.
JD250006 - Sequence 231030 from Patent EP1572962.
JD378360 - Sequence 359384 from Patent EP1572962.
JD354524 - Sequence 335548 from Patent EP1572962.
JD538641 - Sequence 519665 from Patent EP1572962.
JD149579 - Sequence 130603 from Patent EP1572962.
JD518257 - Sequence 499281 from Patent EP1572962.
JD372137 - Sequence 353161 from Patent EP1572962.
JD117723 - Sequence 98747 from Patent EP1572962.
JD392579 - Sequence 373603 from Patent EP1572962.
JD555853 - Sequence 536877 from Patent EP1572962.
AF086072 - Homo sapiens full length insert cDNA clone YZ38H04.
JD502426 - Sequence 483450 from Patent EP1572962.
JD036858 - Sequence 17882 from Patent EP1572962.
JD263824 - Sequence 244848 from Patent EP1572962.
JD083482 - Sequence 64506 from Patent EP1572962.
JD454052 - Sequence 435076 from Patent EP1572962.
JD274533 - Sequence 255557 from Patent EP1572962.
JD351127 - Sequence 332151 from Patent EP1572962.
JD513115 - Sequence 494139 from Patent EP1572962.
JD499872 - Sequence 480896 from Patent EP1572962.
JD412294 - Sequence 393318 from Patent EP1572962.
JD149133 - Sequence 130157 from Patent EP1572962.
JD397249 - Sequence 378273 from Patent EP1572962.
JD345552 - Sequence 326576 from Patent EP1572962.
JD345551 - Sequence 326575 from Patent EP1572962.
JD295400 - Sequence 276424 from Patent EP1572962.
JD328727 - Sequence 309751 from Patent EP1572962.
JD359447 - Sequence 340471 from Patent EP1572962.
JD300358 - Sequence 281382 from Patent EP1572962.
JD504232 - Sequence 485256 from Patent EP1572962.
JD223078 - Sequence 204102 from Patent EP1572962.
JD401439 - Sequence 382463 from Patent EP1572962.
JD436984 - Sequence 418008 from Patent EP1572962.
JD220067 - Sequence 201091 from Patent EP1572962.
JD440533 - Sequence 421557 from Patent EP1572962.
JD056536 - Sequence 37560 from Patent EP1572962.
JD320842 - Sequence 301866 from Patent EP1572962.
JD054383 - Sequence 35407 from Patent EP1572962.
JD061649 - Sequence 42673 from Patent EP1572962.
JD248323 - Sequence 229347 from Patent EP1572962.
JD077498 - Sequence 58522 from Patent EP1572962.
JD404127 - Sequence 385151 from Patent EP1572962.
JD428712 - Sequence 409736 from Patent EP1572962.
JD565634 - Sequence 546658 from Patent EP1572962.
JD527817 - Sequence 508841 from Patent EP1572962.
JD327467 - Sequence 308491 from Patent EP1572962.
JD512136 - Sequence 493160 from Patent EP1572962.
JD510732 - Sequence 491756 from Patent EP1572962.
JD440179 - Sequence 421203 from Patent EP1572962.
JD328480 - Sequence 309504 from Patent EP1572962.
JD310820 - Sequence 291844 from Patent EP1572962.
JD532926 - Sequence 513950 from Patent EP1572962.
JD565357 - Sequence 546381 from Patent EP1572962.
JD453867 - Sequence 434891 from Patent EP1572962.
JD375214 - Sequence 356238 from Patent EP1572962.
MA575454 - JP 2018138019-A/147380: Polycomb-Associated Non-Coding RNAs.
MA575455 - JP 2018138019-A/147381: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000270112.1, ENST00000270112.2, ENST00000270112.3, ENST00000270112.4, ENST00000270112.5, ENST00000270112.6, HUNK_HUMAN, MAKV, NM_014586, P57058, uc317itd.1, uc317itd.2
UCSC ID: ENST00000270112.7_4
RefSeq Accession: NM_014586.2
Protein: P57058 (aka HUNK_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.