Human Gene HYOU1 (ENST00000617285.5_11) from GENCODE V47lift37
  Description: hypoxia up-regulated 1, transcript variant 1 (from RefSeq NM_006389.5)
Gencode Transcript: ENST00000617285.5_11
Gencode Gene: ENSG00000149428.21_21
Transcript (Including UTRs)
   Position: hg19 chr11:118,914,899-118,927,916 Size: 13,018 Total Exon Count: 26 Strand: -
Coding Region
   Position: hg19 chr11:118,916,305-118,926,872 Size: 10,568 Coding Exon Count: 25 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:118,914,899-118,927,916)mRNA (may differ from genome)Protein (999 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HYOU1_HUMAN
DESCRIPTION: RecName: Full=Hypoxia up-regulated protein 1; AltName: Full=150 kDa oxygen-regulated protein; Short=ORP-150; AltName: Full=170 kDa glucose-regulated protein; Short=GRP-170; Flags: Precursor;
FUNCTION: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
SUBUNIT: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
TISSUE SPECIFICITY: Highly expressed in tissues that contain well- developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
INDUCTION: By hypoxia and also by 2-deoxyglucose or tunicamycin.
SIMILARITY: Belongs to the heat shock protein 70 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HYOU1
Diseases sorted by gene-association score: hypoxia (55), ischemia (12)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.10193-0.446 Picture PostScript Text
3' UTR -526.701406-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018181 - Heat_shock_70_CS
IPR013126 - Hsp_70_fam

Pfam Domains:
PF00012 - Hsp70 protein
PF06723 - MreB/Mbl protein

SCOP Domains:
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
53067 - Actin-like ATPase domain

ModBase Predicted Comparative 3D Structure on Q9Y4L1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051087 chaperone binding

Biological Process:
GO:0002931 response to ischemia
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0034976 response to endoplasmic reticulum stress
GO:0036498 IRE1-mediated unfolded protein response
GO:0043066 negative regulation of apoptotic process
GO:0071456 cellular response to hypoxia
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005790 smooth endoplasmic reticulum
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0034663 endoplasmic reticulum chaperone complex
GO:0070062 extracellular exosome
GO:0071682 endocytic vesicle lumen


-  Descriptions from all associated GenBank mRNAs
  LF208452 - JP 2014500723-A/15955: Polycomb-Associated Non-Coding RNAs.
GQ891455 - Homo sapiens clone HEL-S-176 epididymis secretory sperm binding protein mRNA, complete cds.
CR749610 - Homo sapiens mRNA; cDNA DKFZp686N08236 (from clone DKFZp686N08236).
BC072436 - Homo sapiens hypoxia up-regulated 1, mRNA (cDNA clone MGC:90262 IMAGE:5756154), complete cds.
BC004560 - Homo sapiens hypoxia up-regulated 1, mRNA (cDNA clone IMAGE:3959339), complete cds.
U65785 - Human 150 kDa oxygen-regulated protein ORP150 mRNA, complete cds.
AK127324 - Homo sapiens cDNA FLJ45395 fis, clone BRHIP3027191, highly similar to 150 kDa oxygen-regulated protein precursor (Orp150).
JD410760 - Sequence 391784 from Patent EP1572962.
JD444113 - Sequence 425137 from Patent EP1572962.
JD423994 - Sequence 405018 from Patent EP1572962.
JD470855 - Sequence 451879 from Patent EP1572962.
LF376390 - JP 2014500723-A/183893: Polycomb-Associated Non-Coding RNAs.
JD149731 - Sequence 130755 from Patent EP1572962.
JD076951 - Sequence 57975 from Patent EP1572962.
JD446093 - Sequence 427117 from Patent EP1572962.
JD314199 - Sequence 295223 from Patent EP1572962.
JD426055 - Sequence 407079 from Patent EP1572962.
LF376388 - JP 2014500723-A/183891: Polycomb-Associated Non-Coding RNAs.
JD154034 - Sequence 135058 from Patent EP1572962.
JD519697 - Sequence 500721 from Patent EP1572962.
JD416747 - Sequence 397771 from Patent EP1572962.
JD344579 - Sequence 325603 from Patent EP1572962.
JD384827 - Sequence 365851 from Patent EP1572962.
JD374611 - Sequence 355635 from Patent EP1572962.
JD153143 - Sequence 134167 from Patent EP1572962.
LF376387 - JP 2014500723-A/183890: Polycomb-Associated Non-Coding RNAs.
JD436359 - Sequence 417383 from Patent EP1572962.
JD418495 - Sequence 399519 from Patent EP1572962.
JD116266 - Sequence 97290 from Patent EP1572962.
JD382574 - Sequence 363598 from Patent EP1572962.
JD209323 - Sequence 190347 from Patent EP1572962.
AK297260 - Homo sapiens cDNA FLJ52562 complete cds, highly similar to 150 kDa oxygen-regulated protein precursor (Orp150).
JD158443 - Sequence 139467 from Patent EP1572962.
LF376385 - JP 2014500723-A/183888: Polycomb-Associated Non-Coding RNAs.
JD290471 - Sequence 271495 from Patent EP1572962.
JD519531 - Sequence 500555 from Patent EP1572962.
JD416677 - Sequence 397701 from Patent EP1572962.
AK299648 - Homo sapiens cDNA FLJ59408 complete cds, highly similar to 150 kDa oxygen-regulated protein precursor (Orp150).
JD536506 - Sequence 517530 from Patent EP1572962.
JD290639 - Sequence 271663 from Patent EP1572962.
LF376384 - JP 2014500723-A/183887: Polycomb-Associated Non-Coding RNAs.
JD402467 - Sequence 383491 from Patent EP1572962.
JD394052 - Sequence 375076 from Patent EP1572962.
JD026083 - Sequence 7107 from Patent EP1572962.
JD033536 - Sequence 14560 from Patent EP1572962.
LF376383 - JP 2014500723-A/183886: Polycomb-Associated Non-Coding RNAs.
JD543728 - Sequence 524752 from Patent EP1572962.
AK301514 - Homo sapiens cDNA FLJ54564 complete cds, highly similar to 150 kDa oxygen-regulated protein precursor (Orp150).
JD498884 - Sequence 479908 from Patent EP1572962.
JD020352 - Sequence 1376 from Patent EP1572962.
JD504143 - Sequence 485167 from Patent EP1572962.
JD029967 - Sequence 10991 from Patent EP1572962.
AK294905 - Homo sapiens cDNA FLJ56074 complete cds, highly similar to 150 kDa oxygen-regulated protein precursor (Orp150).
AK222756 - Homo sapiens mRNA for oxygen regulated protein precursor variant, clone: HEP00349.
JD279606 - Sequence 260630 from Patent EP1572962.
DQ350134 - Homo sapiens 150 kDa oxygen-regulated protein mRNA, complete cds.
DQ372932 - Homo sapiens 150 kDa oxygen-regulated protein variant 1 mRNA, complete cds.
JD565460 - Sequence 546484 from Patent EP1572962.
JD357741 - Sequence 338765 from Patent EP1572962.
JD137784 - Sequence 118808 from Patent EP1572962.
AK314178 - Homo sapiens cDNA, FLJ94899, Homo sapiens hypoxia up-regulated 1 (HYOU1), mRNA.
GQ900898 - Homo sapiens clone HEL-T-10 epididymis secretory sperm binding protein mRNA, complete cds.
AB384842 - Synthetic construct DNA, clone: pF1KB3707, Homo sapiens HYOU1 gene for hypoxia up-regulated protein 1 precursor, complete cds, without stop codon, in Flexi system.
LF376380 - JP 2014500723-A/183883: Polycomb-Associated Non-Coding RNAs.
LF376379 - JP 2014500723-A/183882: Polycomb-Associated Non-Coding RNAs.
LF376378 - JP 2014500723-A/183881: Polycomb-Associated Non-Coding RNAs.
LF376377 - JP 2014500723-A/183880: Polycomb-Associated Non-Coding RNAs.
AK304264 - Homo sapiens cDNA FLJ54708 complete cds, highly similar to 150 kDa oxygen-regulated protein precursor (Orp150).
LF376376 - JP 2014500723-A/183879: Polycomb-Associated Non-Coding RNAs.
BC017726 - Homo sapiens hypoxia up-regulated 1, mRNA (cDNA clone IMAGE:3898847), partial cds.
AK307624 - Homo sapiens cDNA, FLJ97572.
LF376375 - JP 2014500723-A/183878: Polycomb-Associated Non-Coding RNAs.
LF376373 - JP 2014500723-A/183876: Polycomb-Associated Non-Coding RNAs.
LF376372 - JP 2014500723-A/183875: Polycomb-Associated Non-Coding RNAs.
LF376369 - JP 2014500723-A/183872: Polycomb-Associated Non-Coding RNAs.
LF376367 - JP 2014500723-A/183870: Polycomb-Associated Non-Coding RNAs.
LF376364 - JP 2014500723-A/183867: Polycomb-Associated Non-Coding RNAs.
LF376363 - JP 2014500723-A/183866: Polycomb-Associated Non-Coding RNAs.
LF376362 - JP 2014500723-A/183865: Polycomb-Associated Non-Coding RNAs.
DQ583435 - Homo sapiens piRNA piR-50547, complete sequence.
LF376360 - JP 2014500723-A/183863: Polycomb-Associated Non-Coding RNAs.
LF376358 - JP 2014500723-A/183861: Polycomb-Associated Non-Coding RNAs.
KJ902120 - Synthetic construct Homo sapiens clone ccsbBroadEn_11514 HYOU1 gene, encodes complete protein.
LF376356 - JP 2014500723-A/183859: Polycomb-Associated Non-Coding RNAs.
LF376354 - JP 2014500723-A/183857: Polycomb-Associated Non-Coding RNAs.
LF376350 - JP 2014500723-A/183853: Polycomb-Associated Non-Coding RNAs.
JD138045 - Sequence 119069 from Patent EP1572962.
MA444029 - JP 2018138019-A/15955: Polycomb-Associated Non-Coding RNAs.
MA611967 - JP 2018138019-A/183893: Polycomb-Associated Non-Coding RNAs.
MA611965 - JP 2018138019-A/183891: Polycomb-Associated Non-Coding RNAs.
MA611964 - JP 2018138019-A/183890: Polycomb-Associated Non-Coding RNAs.
MA611962 - JP 2018138019-A/183888: Polycomb-Associated Non-Coding RNAs.
MA611961 - JP 2018138019-A/183887: Polycomb-Associated Non-Coding RNAs.
MA611960 - JP 2018138019-A/183886: Polycomb-Associated Non-Coding RNAs.
MA611957 - JP 2018138019-A/183883: Polycomb-Associated Non-Coding RNAs.
MA611956 - JP 2018138019-A/183882: Polycomb-Associated Non-Coding RNAs.
MA611955 - JP 2018138019-A/183881: Polycomb-Associated Non-Coding RNAs.
MA611954 - JP 2018138019-A/183880: Polycomb-Associated Non-Coding RNAs.
MA611953 - JP 2018138019-A/183879: Polycomb-Associated Non-Coding RNAs.
MA611952 - JP 2018138019-A/183878: Polycomb-Associated Non-Coding RNAs.
MA611950 - JP 2018138019-A/183876: Polycomb-Associated Non-Coding RNAs.
MA611949 - JP 2018138019-A/183875: Polycomb-Associated Non-Coding RNAs.
MA611946 - JP 2018138019-A/183872: Polycomb-Associated Non-Coding RNAs.
MA611944 - JP 2018138019-A/183870: Polycomb-Associated Non-Coding RNAs.
MA611941 - JP 2018138019-A/183867: Polycomb-Associated Non-Coding RNAs.
MA611940 - JP 2018138019-A/183866: Polycomb-Associated Non-Coding RNAs.
MA611939 - JP 2018138019-A/183865: Polycomb-Associated Non-Coding RNAs.
MA611937 - JP 2018138019-A/183863: Polycomb-Associated Non-Coding RNAs.
MA611935 - JP 2018138019-A/183861: Polycomb-Associated Non-Coding RNAs.
MA611933 - JP 2018138019-A/183859: Polycomb-Associated Non-Coding RNAs.
MA611931 - JP 2018138019-A/183857: Polycomb-Associated Non-Coding RNAs.
MA611927 - JP 2018138019-A/183853: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y4L1 (Reactome details) participates in the following event(s):

R-HSA-2197645 SCARF1 (SREC-I) binds ligands
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-3000484 Scavenging by Class F Receptors
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-392499 Metabolism of proteins
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: A8C1Z0, B7Z909, ENST00000617285.1, ENST00000617285.2, ENST00000617285.3, ENST00000617285.4, GRP170, HYOU1_HUMAN, NM_006389, ORP150, Q2I204, Q53H25, Q9Y4L1, uc327qzu.1, uc327qzu.2
UCSC ID: ENST00000617285.5_11
RefSeq Accession: NM_006389.5
Protein: Q9Y4L1 (aka HYOU1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.