ID:IBTK_HUMAN DESCRIPTION: RecName: Full=Inhibitor of Bruton tyrosine kinase; Short=IBtk; FUNCTION: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. SUBUNIT: Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation. SUBCELLULAR LOCATION: Isoform 2: Nucleus. TISSUE SPECIFICITY: Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. SIMILARITY: Contains 3 ANK repeats. SIMILARITY: Contains 2 BTB (POZ) domains. SIMILARITY: Contains 3 RCC1 repeats. SEQUENCE CAUTION: Sequence=AAG27170.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAA92655.2; Type=Erroneous initiation; Sequence=CAI23414.1; Type=Erroneous gene model prediction; Sequence=CAI23416.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2D0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0019901 protein kinase binding GO:0030292 protein tyrosine kinase inhibitor activity
Biological Process: GO:0001933 negative regulation of protein phosphorylation GO:0051209 release of sequestered calcium ion into cytosol GO:0061099 negative regulation of protein tyrosine kinase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
