ID:ICOSL_HUMAN DESCRIPTION: RecName: Full=ICOS ligand; AltName: Full=B7 homolog 2; Short=B7-H2; AltName: Full=B7-like protein Gl50; AltName: Full=B7-related protein 1; Short=B7RP-1; AltName: CD_antigen=CD275; Flags: Precursor; FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. INDUCTION: Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells. SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=BAA31628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300 onward for unknown reason;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75144
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
